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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
22/11/2013 |
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Data da última atualização: |
05/12/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SIDER, L. H.; HEATON, M. P.; CHITKO-McKOWN, C. G.; HARHAY, G. P.; SMITH, T. P. L.; LEYMASTER, K. A.; LAEGREID, W. W.; CLAWSON, M. L. |
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Afiliação: |
LUCIA HELENA SIDER, CNPC; Michael P. Heaton, United States Department of Agriculture (USDA). Agricultural Research Service (ARS), U.S. Meat Animal Research Center (USMARC), State Spur 18D, Clay Center, NE 68933, USA.; Carol G Chitko-McKown, United States Department of Agriculture (USDA) Agricultural Research Service (ARS), U.S. Meat Animal Research Center (USMARC), State Spur 18D, Clay Center, NE 68933, USA.; Greg P. Harhay, United States Department of Agriculture (USDA) Agricultural Research Service (ARS), U.S. Meat Animal Research Center (USMARC), State Spur 18D, Clay Center, NE 68933, USA.; Timothy P. L. Smith, United States Department of Agriculture (USDA). Agricultural Research Service (ARS), U.S. Meat Animal Research Center (USMARC), State Spur 18D, Clay Center, NE 68933, USA.; Kreg A. Leymaster, 1United States Department of Agriculture (USDA) Agricultural Research Service (ARS), U.S. Meat Animal Research Center (USMARC), State Spur 18D, Clay Center, NE 68933, USA.; William W. Laegreid, Department of Veterinary Sciences, University of Wyoming, 1174 Snowy Range Road, Laramie, WY 82070, USA.; Michael L. Clawson, United States Department of Agriculture (USDA). Agricultural Research Service (ARS), U.S. Meat Animal Research Center (USMARC), State Spur 18D, Clay Center, NE 68933, USA. |
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Título: |
Small ruminant lentivirus genetic subgroups associate with sheep TMEM154 genotypes. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Veterinary Research, v. 44, p. 64, Jul. 2013. |
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DOI: |
10.1186/1297-9716-44-64 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Small ruminant lentiviruses (SRLVs) are prevalent in North American sheep and a major cause of production losses for the U.S. sheep industry. Sheep susceptibility to SRLV infection is influenced by genetic variation within the ovine transmembrane 154 gene (TMEM154). Animals with either of two distinct TMEM154 haplotypes that both encode glutamate at position 35 of the protein (E35) are at greater risk of SRLV infection than those homozygous with a lysine (K35) haplotype. Prior to this study, it was unknown if TMEM154 associations with infection are influenced by SRLV genetic subgroups. Accordingly, our goals were to characterize SRLVs naturally infecting sheep from a diverse U.S. Midwestern flock and test them for associations with TMEM154 E35K genotypes. Two regions of the SRLV genome were targeted for proviral amplification, cloning, sequence analysis, and association testing with TMEM154 E35K genotypes: gag and the transmembrane region of env. Independent analyses of gag and env sequences showed that they clustered in two subgroups (1 and 2), they were distinct from SRLV subtypes originating from Europe, and that subgroup 1 associated with hemizygous and homozygous TMEM154 K35 genotypes and subgroup 2 with hemi- and homozygous E35 genotypes (gag p < 0.001, env p = 0.01). These results indicate that SRLVs in the U.S. have adapted to infect sheep with specific TMEM154 E35K genotypes. Consequently, both host and SRLV genotypes affect the relative risk of SRLV infection in sheep. MenosAbstract: Small ruminant lentiviruses (SRLVs) are prevalent in North American sheep and a major cause of production losses for the U.S. sheep industry. Sheep susceptibility to SRLV infection is influenced by genetic variation within the ovine transmembrane 154 gene (TMEM154). Animals with either of two distinct TMEM154 haplotypes that both encode glutamate at position 35 of the protein (E35) are at greater risk of SRLV infection than those homozygous with a lysine (K35) haplotype. Prior to this study, it was unknown if TMEM154 associations with infection are influenced by SRLV genetic subgroups. Accordingly, our goals were to characterize SRLVs naturally infecting sheep from a diverse U.S. Midwestern flock and test them for associations with TMEM154 E35K genotypes. Two regions of the SRLV genome were targeted for proviral amplification, cloning, sequence analysis, and association testing with TMEM154 E35K genotypes: gag and the transmembrane region of env. Independent analyses of gag and env sequences showed that they clustered in two subgroups (1 and 2), they were distinct from SRLV subtypes originating from Europe, and that subgroup 1 associated with hemizygous and homozygous TMEM154 K35 genotypes and subgroup 2 with hemi- and homozygous E35 genotypes (gag p < 0.001, env p = 0.01). These results indicate that SRLVs in the U.S. have adapted to infect sheep with specific TMEM154 E35K genotypes. Consequently, both host and SRLV genotypes affect the relative risk of SRLV infec... Mostrar Tudo |
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Palavras-Chave: |
Animal genetic; Diseases; Genotipagem; Genotypes; SRLV; TMEM154. |
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Thesagro: |
Doença animal; Filogenia; Genética animal; Ovino; Virologia; Virus. |
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Thesaurus Nal: |
Genotyping; Lentivirus; Phylogeny; Sheep; Small ruminants; Virology. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/92973/1/api-Small-ruminant-lentivirus.pdf
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Marc: |
LEADER 02633naa a2200433 a 4500
001 1971944
005 2023-12-05
008 2013 bl uuuu u00u1 u #d
024 7 $a10.1186/1297-9716-44-64$2DOI
100 1 $aSIDER, L. H.
245 $aSmall ruminant lentivirus genetic subgroups associate with sheep TMEM154 genotypes.$h[electronic resource]
260 $c2013
520 $aAbstract: Small ruminant lentiviruses (SRLVs) are prevalent in North American sheep and a major cause of production losses for the U.S. sheep industry. Sheep susceptibility to SRLV infection is influenced by genetic variation within the ovine transmembrane 154 gene (TMEM154). Animals with either of two distinct TMEM154 haplotypes that both encode glutamate at position 35 of the protein (E35) are at greater risk of SRLV infection than those homozygous with a lysine (K35) haplotype. Prior to this study, it was unknown if TMEM154 associations with infection are influenced by SRLV genetic subgroups. Accordingly, our goals were to characterize SRLVs naturally infecting sheep from a diverse U.S. Midwestern flock and test them for associations with TMEM154 E35K genotypes. Two regions of the SRLV genome were targeted for proviral amplification, cloning, sequence analysis, and association testing with TMEM154 E35K genotypes: gag and the transmembrane region of env. Independent analyses of gag and env sequences showed that they clustered in two subgroups (1 and 2), they were distinct from SRLV subtypes originating from Europe, and that subgroup 1 associated with hemizygous and homozygous TMEM154 K35 genotypes and subgroup 2 with hemi- and homozygous E35 genotypes (gag p < 0.001, env p = 0.01). These results indicate that SRLVs in the U.S. have adapted to infect sheep with specific TMEM154 E35K genotypes. Consequently, both host and SRLV genotypes affect the relative risk of SRLV infection in sheep.
650 $aGenotyping
650 $aLentivirus
650 $aPhylogeny
650 $aSheep
650 $aSmall ruminants
650 $aVirology
650 $aDoença animal
650 $aFilogenia
650 $aGenética animal
650 $aOvino
650 $aVirologia
650 $aVirus
653 $aAnimal genetic
653 $aDiseases
653 $aGenotipagem
653 $aGenotypes
653 $aSRLV
653 $aTMEM154
700 1 $aHEATON, M. P.
700 1 $aCHITKO-McKOWN, C. G.
700 1 $aHARHAY, G. P.
700 1 $aSMITH, T. P. L.
700 1 $aLEYMASTER, K. A.
700 1 $aLAEGREID, W. W.
700 1 $aCLAWSON, M. L.
773 $tVeterinary Research$gv. 44, p. 64, Jul. 2013.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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Registro |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
20/11/1996 |
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Data da última atualização: |
31/08/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
Nacional - B |
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Autoria: |
MASCIOLI, A. dos S.; ALENCAR, M. M. de; BARBOSA, P. F.; OLIVEIRA, M. C. de S.; NOVAES, A. P. de. |
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Afiliação: |
ARTHUR DOS SANTOS MASCIOLI, UNESP; MAURICIO MELLO DE ALENCAR, CPPSE; PEDRO FRANKLIN BARBOSA, CPPSE; MARCIA CRISTINA DE SENA OLIVEIRA, CPPSE; ANTONIO PEREIRA DE NOVAES, CNPDIA. |
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Título: |
Influência de fatores de meio sobre pesos de animais da Raça Canchim. |
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Ano de publicação: |
1996 |
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Fonte/Imprenta: |
Revista da Sociedade Brasileira de Zootecnia, Viçosa, MG. v.25, n.5, p.853-865, 1996. |
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Idioma: |
Português |
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Conteúdo: |
O objetivo deste trabalho foi estudar os efeitos de alguns fatores de meio sobre os pesos ao nascimento (PN), a desmama (PD) e aos 12 (P12), 18 (P18) e 24 (P24) meses de idade de animais da raca Canchim produzidos em cinco fazendas do Estado de São Paulo. |
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Palavras-Chave: |
Canchim; Caracteristicas de cresciemnto; Fatores nao geneticos; Non genetic factors. |
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Thesagro: |
Gado de Corte. |
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Thesaurus NAL: |
beef cattle; growth traits. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/119486/1/275.pdf
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Marc: |
LEADER 01036naa a2200253 a 4500
001 1043303
005 2021-08-31
008 1996 bl uuuu u00u1 u #d
100 1 $aMASCIOLI, A. dos S.
245 $aInfluência de fatores de meio sobre pesos de animais da Raça Canchim.$h[electronic resource]
260 $c1996
520 $aO objetivo deste trabalho foi estudar os efeitos de alguns fatores de meio sobre os pesos ao nascimento (PN), a desmama (PD) e aos 12 (P12), 18 (P18) e 24 (P24) meses de idade de animais da raca Canchim produzidos em cinco fazendas do Estado de São Paulo.
650 $abeef cattle
650 $agrowth traits
650 $aGado de Corte
653 $aCanchim
653 $aCaracteristicas de cresciemnto
653 $aFatores nao geneticos
653 $aNon genetic factors
700 1 $aALENCAR, M. M. de
700 1 $aBARBOSA, P. F.
700 1 $aOLIVEIRA, M. C. de S.
700 1 $aNOVAES, A. P. de
773 $tRevista da Sociedade Brasileira de Zootecnia, Viçosa, MG.$gv.25, n.5, p.853-865, 1996.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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