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Registro Completo |
Biblioteca(s): |
Embrapa Suínos e Aves; Embrapa Unidades Centrais. |
Data corrente: |
11/09/2023 |
Data da última atualização: |
11/09/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
HAACH, V.; BASTOS, A. P. A.; GAVA, D.; FONSECA, F. M. da; MORES, M. A. Z.; COLDEBELLA, A.; FRANCO, A. C.; SCHAEFER, R. |
Afiliação: |
VANESSA HAACH, Universidade Federal do Rio Grande do Sul; ANA PAULA ALMEIDA BASTOS, CNPSA; DANIELLE GAVA, CNPSA; FRANCISCO NOE DA FONSECA, GEM; MARCOS ANTONIO ZANELLA MORES, CNPSA; ARLEI COLDEBELLA, CNPSA; ANA CLÁUDIA FRANCO, Universidade Federal do Rio Grande do Sul; REJANE SCHAEFER, CNPSA. |
Título: |
A polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
Virology Journal, v. 20, article number 181, 2023. |
DOI: |
https://doi.org/10.1186/s12985-023-02153-5 |
Idioma: |
Inglês |
Conteúdo: |
Abstract: Background: Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses. Methods: This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs. Results: A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies and virus-neutralizing activity. Furthermore, it induced a significant maturation of macrophages, and proliferation of B lymphocytes, effector and central memory CD4+ and CD8+ T cells, and CD8+ T lymphocytes producing interferon-γ. Also, the vaccine demonstrated potential to confer long-lasting immunity until the market age of pigs and proved to be safe and non-cytotoxic to pigs. Conclusions: This virosome platform allows flexibility to adjust the vaccine content to reflect the diversity of circulating IAVs in swine in Brazil. The vaccination of pigs may reduce the impact of the disease on swine production and the risk of swine-to-human transmission. |
Palavras-Chave: |
Cellular immunity; Virosomal vaccine. |
Thesagro: |
Imunidade; Suíno; Vacina. |
Thesaurus Nal: |
Humoral immunity; Influenza A virus; Swine. |
Categoria do assunto: |
-- L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1156557/1/final10093.pdf
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Marc: |
LEADER 02316naa a2200313 a 4500 001 2156557 005 2023-09-11 008 2023 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1186/s12985-023-02153-5$2DOI 100 1 $aHAACH, V. 245 $aA polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs.$h[electronic resource] 260 $c2023 520 $aAbstract: Background: Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses. Methods: This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs. Results: A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies and virus-neutralizing activity. Furthermore, it induced a significant maturation of macrophages, and proliferation of B lymphocytes, effector and central memory CD4+ and CD8+ T cells, and CD8+ T lymphocytes producing interferon-γ. Also, the vaccine demonstrated potential to confer long-lasting immunity until the market age of pigs and proved to be safe and non-cytotoxic to pigs. Conclusions: This virosome platform allows flexibility to adjust the vaccine content to reflect the diversity of circulating IAVs in swine in Brazil. The vaccination of pigs may reduce the impact of the disease on swine production and the risk of swine-to-human transmission. 650 $aHumoral immunity 650 $aInfluenza A virus 650 $aSwine 650 $aImunidade 650 $aSuíno 650 $aVacina 653 $aCellular immunity 653 $aVirosomal vaccine 700 1 $aBASTOS, A. P. A. 700 1 $aGAVA, D. 700 1 $aFONSECA, F. M. da 700 1 $aMORES, M. A. Z. 700 1 $aCOLDEBELLA, A. 700 1 $aFRANCO, A. C. 700 1 $aSCHAEFER, R. 773 $tVirology Journal$gv. 20, article number 181, 2023.
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Registro original: |
Embrapa Suínos e Aves (CNPSA) |
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Registros recuperados : 39 | |
21. | | SCHAEFER, R.; GAVA, D.; HAACH, V.; CANTAO, M. E.; NELSON, M. I. Novel human-like H1N1 swine influenza virus with the six internal genes derived from H1N1/2009 virus. In: CONGRESSO BRASILEIRO DE VIROLOGIA, 28.; ENCONTRO DE VIROLOGIA DO MERCOSUL, 12., 2017, Belo Horizonte. Trabalho pôsteres... Brasília: SBV, 2017.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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22. | | HAACH, V.; ORTIZ, L. C.; MION, L.; GAVA, D.; BIONDO, N.; SCHAEFER, R.; ZANELLA, R.; ZANELLA, J. R. C. Caracterização do perfil de anticorpos para influenza A em fêmeas suínas e o reflexo na imunidade da progênie. In: JORNADA DE INICIAÇÃO CIENTÍFICA, 8., 2014, Concórdia. Anais... Brasília: Embrapa, 2014. p. 15-16. JINC 2014.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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23. | | SCHAEFER, R.; GAVA, D.; HAACH, V.; SERRÃO, V. H. B.; CANTAO, M. E.; ZANELLA, J. R. C. Genetic diversity of porcine circovirus type 2 causing clinical disease in Brazilian pig herds concomitant with PCV2 vaccination. Virus Reviews & Research, Brasília, DF, v. 20, p. 247-248, Oct. 2015. Supplement 1, ref. VV335. Edição dos Resumos do XXVI Brazilian Congress of Virology, X Mercosur Meeting of Virology, Florianóplis, SC, Oct. 2015.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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24. | | GAVA, D.; JOSHI, L. R.; MOHR, K. A.; HAACH, V.; CARON, L.; SCHAEFER, R.; DIEL, D. G. Genetic characterization and phylogenetic analysis of senecavirus A circulating in the US and in Brazil. In: BRAZILIAN CONGRESS OF VIROLOGY, 27.; MERCOSUR MEETING OF VIROLOGY,11., 2016, Pirenópolis. Abstracts: posters: oral presentation. Brasília, DF: SBV, 2016. Publicado na Virus Reviews and Research, Brasília, n. 20, v. 2, p. 131-132, 2016.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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25. | | RECH, R. R.; GAVA, D.; SILVA, M. C. da; FERNANDES, L. T.; HAACH, V.; ZANELLA, J. R. C.; SCHAEFER, R. Porcine respiratory disease complex after the introduction of H1N1/2009 influenza virus in Brazil. Zoonoses and Public Health, v. 65, n.1, p. e155-e161, 2018.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
Biblioteca(s): Embrapa Suínos e Aves. |
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26. | | GAVA, D.; HAACH, V.; MORES, M. A. Z.; MORES, N.; GRINGS, V. H.; ZANELLA, J. R. C.; SCHAEFER, R. Senecavirus A outbreak affecting piglets and sows in southern Brazil. . In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 24., Dublin. Abstracts Book... Dublin, Ireland: IPVS, 2016. p. 456.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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27. | | TOCHETTO, C.; JUNQUEIRA, D. M.; ANDERSON, T. K.; GAVA, D.; HAACH, V.; CANTAO, M. E.; VINCENT, A. L.; SCHAEFER, R. Introductions of pre-2009 human-origin seasonal influenza A viruses in Brazilian swine herds. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 26., 2022, Rio de Janeiro. Proceedings... Rio de Janeiro, RJ: IPVS: Abraves, 2022. p. 700.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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28. | | MORI, A. P.; PERETTI, R. C.; FERRAZ, R.; FERRAZ, G. M.; GAVA, D.; HAACH, V.; SCHAEFER, R. Occurrence of influenza A virus subtypes in Brazil. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 26., 2020, Rio de Janeiro. Proceedings... Rio de Janeiro, RJ: IPVS, 2020. p. 773.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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29. | | MORI, A. P.; PERETTI, R. C.; FERRAZ, R.; FERRAZ, G. M.; GAVA, D.; HAACH, V.; SCHAEFER, R. Occurrence of influenza A virus subtypes in Brazil. In: ALLEN D. LEMAN SWINE CONFERENCE, 2020, Saint Paul. Research Abstract. Saint Paul: University of Minnesota/College of Veterinary Medicine, 2020. Poster number: 70.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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30. | | HAACH, V.; BASTOS, A. P. A.; GAVA, D.; FONSECA, F. M. da; MORES, M. A. Z.; COLDEBELLA, A.; FRANCO, A. C.; SCHAEFER, R. Cellular and humoral immunity elicited by an Influenza A polyvalent virosomal vaccine in pigs. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 26., 2022, Rio de Janeiro. Proceedings... Rio de Janeiro, RJ: IPVS: Abraves, 2022. p. 421.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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31. | | HAACH, V.; BASTOS, A. P. A.; GAVA, D.; FONSECA, F. M. da; MORES, M. A. Z.; COLDEBELLA, A.; FRANCO, A. C.; SCHAEFER, R. A polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs. Virology Journal, v. 20, article number 181, 2023.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 3 |
Biblioteca(s): Embrapa Suínos e Aves; Embrapa Unidades Centrais. |
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32. | | MACIAG, S. S.; BELLAVER, F. A. V.; BOMBASSARO, G. E.; HAACH, V.; MORES, M. A. Z.; BARON, L. F.; COLDEBELLA, A.; BASTOS, A. P. A. On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets. Scientific Reports, v. 12, n. 15630, 2022.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
Biblioteca(s): Embrapa Suínos e Aves. |
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33. | | JUNQUEIRA, D. M.; TOCHETTO, C.; ANDERSON, T. K.; GAVA, D.; HAACH, V.; CANTAO, M. E.; BAKER, A. L. V.; SCHAEFER, R. Human-to-swine introductions and onward transmission of 2009 H1N1 pandemic influenza viruses in Brazil. Frontiers in Microbiology, v. 14, article 1243567, 2023.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
Biblioteca(s): Embrapa Suínos e Aves. |
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34. | | JUNQUEIRA, D. M.; ANDERSON, T. K.; TOCHETTO, C.; GAVA, D.; HAACH, V.; CANTAO, M. E.; ZANELLA, J. R. C.; VINCENT, A. L.; SCHAEFER, R. Human-to-swine spillover and onward transmission of H1N1pdm09 in Brazil. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 26., 2022, Rio de Janeiro. Proceedings... Rio de Janeiro, RJ: IPVS: Abraves, 2022. p. 690.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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35. | | TOCHETTO, C.; JUNQUEIRA, D. M.; ANDERSON, T. K.; GAVA, D.; HAACH, V.; CANTAO, M. E.; BAKER, A. L. V.; SCHAEFER, R. Introductions of human-origin Seasonal H3N2, H1N2 and pre-2009 H1N1 Influenza Viruses to swine in Brazil. Viruses, v. 15, n. 576, 2023.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
Biblioteca(s): Embrapa Suínos e Aves. |
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36. | | GAVA, D.; LORENZETT, M. P.; HAACH, V.; DRIEMEIER, D.; JOSHI, L. R.; MOHR, K. A.; DIEL, D. G.; CARON, L.; MORES, N.; MORES, M. A. Z.; SCHAEFER, R. Neonatal pig mortality associated with senecavirus A. In: BRAZILIAN CONGRESS OF VIROLOGY, 27.; MERCOSUR MEETING OF VIROLOGY,11., 2016, Pirenópolis. Abstracts: posters: oral presentation. Brasília, DF: SBV, 2016. Publicado na Virus Reviews and Research, Brasília, n. 20, v. 2, p. 23, 2016.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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37. | | IBELLI, A. M. G.; FERNANDES, L.; HAACH, V.; GAVA, D.; BASTOS, A. P. A.; OKINO, C. H.; PEIXOTO, J. de O.; FONSECA, F. M. da; MORES, M. A. Z.; CANTAO, M. E.; SCHAEFER, R.; LEDUR, M. C. Transcriptomic profiling shows the induction of humoral and cellular response-related genes in pigs following vaccination with an Influenza A nanovaccine. In: INTERNATIONAL VETERINARY IMMUNOLOGY SYMPOSIUM, 13., 2023, Satellite Meeting. Programme & Abstracts... Kruger Park/South Africa: IVIS, 2023. p. 109.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Suínos e Aves. |
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38. | | FONSECA, F. M. da; HAACH, V.; BELLAVER, F. V.; BOMBASSARO, G.; GAVA, D.; SILVA, L. P. da; BARON, L. F.; SIMONELLY, M.; CARVALHO, W. A.; SCHAEFER, R.; BASTOS, A. P. A. Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine. Virology Journal, v. 20, 2023. Article number 187. Na publicação: Francisco Noé Fonseca; Ana Paula Bastos.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 3 |
Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
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39. | | IBELLI, A. M. G.; PEIXOTO, J. de O.; FERNANDES, L. T.; HAACH, V.; GAVA, D.; BASTOS, A. P. A.; FONSECA, F. M. da; MORES, M. A. Z.; CANTAO, M. E.; SCHAEFER, R.; LEDUR, M. C. Molecular mechanisms involved with influenza A nanovaccine immunogenicity in pigs. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 12., 2022, Rotterdam. Proceedings: technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen: Wageningen Academic Publishers, 2022. Edited by R. F. Veerkamp and Y. de Haas.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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Registros recuperados : 39 | |
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Nenhum registro encontrado para a expressão de busca informada. |
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