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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
11/01/2024 |
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Data da última atualização: |
08/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PEDRINHA, V. F.; SANTOS, L. M.; GONÇALVES, C. P.; GARCIA, M. T.; LAMEIRA, O. A.; QUEIROGA, C. L.; MARCUCCI, M. C.; SHAHBAZI, M.-A.; SHARMA, P. K.; JUNQUEIRA, J. C.; SIPERT, C. R.; ANDRADE, F. B. de. |
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Afiliação: |
VICTOR FELIZ PEDRINHA, UNIVERSIDADE DE SÃO PAULO; LETÍCIA MARTINS SANTOS, UNIVERSIDADE DE SÃO PAULO; CAROLINA PASSARELLI GONÇALVES, UNIVERSIDADE FEDERAL DO ABC; MAÍRA TERRA GARCIA, UNIVERSIDADE ESTADUAL PAULISTA "JÚLIO DE MESQUITA FILHO"; OSMAR ALVES LAMEIRA, CPATU; CARMEN LUCIA QUEIROGA, UNIVERSIDADE ESTADUAL DE CAMPINAS; MARIA CRISTINA MARCUCCI, UNIVERSIDADE ESTADUAL PAULISTA "JÚLIO DE MESQUITA FILHO"; MOHAMMAD-ALI SHAHBAZI, UNIVERSITY OF GRONINGEN; PRASHANT KUMAR SHARMA, UNIVERSITY OF GRONINGEN; JULIANA CAMPOS JUNQUEIRA, UNIVERSIDADE ESTADUAL PAULISTA "JÚLIO DE MESQUITA FILHO"; CARLA RENATA SIPERT, UNIVERSIDADE DE SÃO PAULO; FLAVIANA BOMBARDA DE ANDRADE, UNIVERSIDADE DE SÃO PAULO. |
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Título: |
Effects of natural antimicrobial compounds propolis and copaiba on periodontal ligament fibroblasts, molecular docking, and in vivo study in Galleria mellonella. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Biomedicine & Pharmacotherapy, v. 171, 116139, 2024. |
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DOI: |
https://doi.org/10.1016/j.biopha.2024.116139 |
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Idioma: |
Inglês |
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Conteúdo: |
Root canal treatment addresses infectious processes that require control. Occasionally, the radicular pulp is vital and inflamed, presenting a superficial infection. To preserve pulpal remnants, conservative procedures have gained favor, employing anti-inflammatory medications. This study investigated the effects of propolis (PRO), and copaiba oil-resin (COR) associated with hydrocortisone (H) and compared their impact to that of Otosporin® concerning cytotoxic and genotoxic activity, cytokine detection, and toxicity in the Galleria mellonella model. Human periodontal ligament fibroblasts (PDLFs) were exposed to drug concentrations and evaluated by the MTT assay. Associations were tested from concentrations that did not compromise cell density. Genotoxicity was evaluated through micronucleus counting, while cytokines IL-6 and TGF-β1 were detected in the cell supernatant using ELISA. Molecular docking simulations were conducted, considering the major compounds identified in PRO, COR, and H. Increasing concentrations of PRO and COR were assessed for acute toxicity in Galleria mellonella model. Cellular assays were analyzed using one-way ANOVA followed by Tukey tests, while larval survivals were evaluated using the Log-rank (Mantel-Cox) test (α = 0.05). PRO and COR promoted PDLFs proliferation, even in conjunction with H. No changes in cell metabolism were observed concerning cytokine |
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Palavras-Chave: |
Ancoragem molecular; Doenças da polpa dentária; Toxicidade. |
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Thesagro: |
Própolis. |
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Thesaurus Nal: |
Toxicity. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1160736/1/Effects-of-natural-antimicrobial.pdf
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Marc: |
LEADER 02441naa a2200325 a 4500
001 2160736
005 2024-02-08
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.biopha.2024.116139$2DOI
100 1 $aPEDRINHA, V. F.
245 $aEffects of natural antimicrobial compounds propolis and copaiba on periodontal ligament fibroblasts, molecular docking, and in vivo study in Galleria mellonella.$h[electronic resource]
260 $c2024
520 $aRoot canal treatment addresses infectious processes that require control. Occasionally, the radicular pulp is vital and inflamed, presenting a superficial infection. To preserve pulpal remnants, conservative procedures have gained favor, employing anti-inflammatory medications. This study investigated the effects of propolis (PRO), and copaiba oil-resin (COR) associated with hydrocortisone (H) and compared their impact to that of Otosporin® concerning cytotoxic and genotoxic activity, cytokine detection, and toxicity in the Galleria mellonella model. Human periodontal ligament fibroblasts (PDLFs) were exposed to drug concentrations and evaluated by the MTT assay. Associations were tested from concentrations that did not compromise cell density. Genotoxicity was evaluated through micronucleus counting, while cytokines IL-6 and TGF-β1 were detected in the cell supernatant using ELISA. Molecular docking simulations were conducted, considering the major compounds identified in PRO, COR, and H. Increasing concentrations of PRO and COR were assessed for acute toxicity in Galleria mellonella model. Cellular assays were analyzed using one-way ANOVA followed by Tukey tests, while larval survivals were evaluated using the Log-rank (Mantel-Cox) test (α = 0.05). PRO and COR promoted PDLFs proliferation, even in conjunction with H. No changes in cell metabolism were observed concerning cytokine
650 $aToxicity
650 $aPrópolis
653 $aAncoragem molecular
653 $aDoenças da polpa dentária
653 $aToxicidade
700 1 $aSANTOS, L. M.
700 1 $aGONÇALVES, C. P.
700 1 $aGARCIA, M. T.
700 1 $aLAMEIRA, O. A.
700 1 $aQUEIROGA, C. L.
700 1 $aMARCUCCI, M. C.
700 1 $aSHAHBAZI, M.-A.
700 1 $aSHARMA, P. K.
700 1 $aJUNQUEIRA, J. C.
700 1 $aSIPERT, C. R.
700 1 $aANDRADE, F. B. de
773 $tBiomedicine & Pharmacotherapy$gv. 171, 116139, 2024.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Florestas. Para informações adicionais entre em contato com cnpf.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
12/05/2020 |
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Data da última atualização: |
27/05/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
MATTOS, B. D.; TARDY, B. L.; GRECA, L. G.; KÄMÄRÄINEN, T.; XIANG, W.; CUSOLA, O.; MAGALHAES, W. L. E.; ROJAS, O. J. |
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Afiliação: |
SCHOOL OF CHEMICAL ENGINEERING, AALTO UNIVERSITY; SCHOOL OF CHEMICAL ENGINEERING, AALTO UNIVERSITY; SCHOOL OF CHEMICAL ENGINEERING, AALTO UNIVERSITY; SCHOOL OF CHEMICAL ENGINEERING, AALTO UNIVERSITY; SCHOOL OF CHEMICAL ENGINEERING, AALTO UNIVERSITY; UNIVERSITAT POLITÈCNICA DE CATALUNYA, ESCOLA SUPERIOR D’ENGINYERIES INDUSTRIAL, AEROESPACIAL I AUDIOVISUAL DE TERRASSA; WASHINGTON LUIZ ESTEVES MAGALHAES, CNPF; SCHOOL OF CHEMICAL ENGINEERING, AALTO UNIVERSITY. |
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Título: |
Nanofibrillar networks enable universal assembly of superstructured particle constructs. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Science Advances, v. 6, n. 19, eaaz7328, May 2020. |
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ISBN: |
2375-2548 |
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DOI: |
https://doi.org/10.1126/sciadv.aaz7328 |
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Idioma: |
Inglês |
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Conteúdo: |
Superstructured colloidal materials exploit the synergies between components to develop new or enhanced functions. Cohesion is a primary requirement for scaling up these assemblies into bulk materials, and it has only been fulfilled in case-specific bases. Here, we demonstrate that the topology of nanonetworks formed from cellulose nanofibrils (CNFs) enables robust superstructuring with virtually any particle. An intermixed network of fibrils with particles increases the toughness of the assemblies by up to three orders of magnitude compared, for instance, to sintering. Supramolecular cohesion is transferred from the fibrils to the constructs following a power law, with a constant decay factor for particle sizes from 230 nm to 40 ?m. Our findings are applicable to other nanofiber dimensions via a rationalization of the morphological aspects of both particles and nanofibers. CNFbased cohesion will move developments of functional colloids from laboratory-scale toward their implementation in large-scale nanomanufacturing of bulk materials. |
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Palavras-Chave: |
Nanocellulose; Nanofibrilla. |
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Thesagro: |
Celulose. |
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Thesaurus NAL: |
Cellulose. |
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Categoria do assunto: |
K Ciência Florestal e Produtos de Origem Vegetal |
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Marc: |
LEADER 01843naa a2200277 a 4500
001 2122280
005 2020-05-27
008 2020 bl uuuu u00u1 u #d
022 $a2375-2548
024 7 $ahttps://doi.org/10.1126/sciadv.aaz7328$2DOI
100 1 $aMATTOS, B. D.
245 $aNanofibrillar networks enable universal assembly of superstructured particle constructs.$h[electronic resource]
260 $c2020
520 $aSuperstructured colloidal materials exploit the synergies between components to develop new or enhanced functions. Cohesion is a primary requirement for scaling up these assemblies into bulk materials, and it has only been fulfilled in case-specific bases. Here, we demonstrate that the topology of nanonetworks formed from cellulose nanofibrils (CNFs) enables robust superstructuring with virtually any particle. An intermixed network of fibrils with particles increases the toughness of the assemblies by up to three orders of magnitude compared, for instance, to sintering. Supramolecular cohesion is transferred from the fibrils to the constructs following a power law, with a constant decay factor for particle sizes from 230 nm to 40 ?m. Our findings are applicable to other nanofiber dimensions via a rationalization of the morphological aspects of both particles and nanofibers. CNFbased cohesion will move developments of functional colloids from laboratory-scale toward their implementation in large-scale nanomanufacturing of bulk materials.
650 $aCellulose
650 $aCelulose
653 $aNanocellulose
653 $aNanofibrilla
700 1 $aTARDY, B. L.
700 1 $aGRECA, L. G.
700 1 $aKÄMÄRÄINEN, T.
700 1 $aXIANG, W.
700 1 $aCUSOLA, O.
700 1 $aMAGALHAES, W. L. E.
700 1 $aROJAS, O. J.
773 $tScience Advances$gv. 6, n. 19, eaaz7328, May 2020.
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Embrapa Florestas (CNPF) |
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