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Registro Completo |
Biblioteca(s): |
Embrapa Amapá. |
Data corrente: |
29/07/2022 |
Data da última atualização: |
08/08/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
ÇIÇEK, S. S.; PÉREZ, M. G; WENZEL-STORJOHANN, A.; BEZERRA, R. M.; SEGOVIA, J. F. O.; GIRRESER, U.; KANZAKI, I.; TASDEMIR, D. |
Afiliação: |
SERHAT S. ÇIÇEK, KIEL UNIVERSITY; MAYRA GALARZA PÉREZ, KIEL UNIVERSITY; ARLETTE WENZEL-STORJOHANN, GEOMAR; ROBERTO M. BEZERRA, UNIFAP; JORGE FEDERICO ORELLANA SEGOVIA, CPAF-AP; ULRICH GIRRESER, KIEL UNIVERSITY; ISAMU KANZAKI, UNB; DENIZ TASDEMIR, GEOMAR. |
Título: |
Antimicrobial prenylated isoflavones from the leaves of the Amazonian medicinal plant vatairea guianensis Aubl. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Journal of Natural Products, v. 85, p. 927-935, 2022. |
DOI: |
https://doi.org/10.1021/acs.jnatprod.1c01035 |
Idioma: |
Inglês |
Conteúdo: |
Vatairea guianenis Aubl. (Fabaceae) is an Amazonian medicinal plant species traditionally used for treating skin diseases. In an initial screening, a V. guianensis leaf extract and its subextracts showed antibacterial and antifungal activities. The EtOAc subextract was selected for chemical workup and afforded five known (1-4 and 8) and six undescribed isoflavones, vatairenones C-H( 5-7 and 9-11). All isoflavones are prenylated in position C-8, displaying either chain-prenylated (1-7) or ring-closed forms (8-11). The most bioactive compound (3) exhibited in vitro activity against clinically relevant bacteria and fungi with IC50 values ranging from 6.8 to 26.9 μM. Due to its broad antimicrobial activity and low general toxicity, compound 3 is a potential lead compound for structural modifications. The results of the present study support the ethnomedicinal use of V. guianensis in the treatment of dermatological disorders. 1H NMR spectra of some of the isolated compounds showed intricate signal patterns, which might explain repeated errors in assigning the correct structure of the isoflavonoid B-ring in the literature and which we resolved by higher order spectra simulations. |
Thesagro: |
Planta Medicinal. |
Thesaurus Nal: |
Fabaceae; Medicinal plants. |
Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1145058/1/CPAF-AP-2022-Antimicrobial-Prenylated-Isoflavones.pdf
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Marc: |
LEADER 01980naa a2200253 a 4500 001 2145058 005 2022-08-08 008 2022 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1021/acs.jnatprod.1c01035$2DOI 100 1 $aÇIÇEK, S. S. 245 $aAntimicrobial prenylated isoflavones from the leaves of the Amazonian medicinal plant vatairea guianensis Aubl.$h[electronic resource] 260 $c2022 520 $aVatairea guianenis Aubl. (Fabaceae) is an Amazonian medicinal plant species traditionally used for treating skin diseases. In an initial screening, a V. guianensis leaf extract and its subextracts showed antibacterial and antifungal activities. The EtOAc subextract was selected for chemical workup and afforded five known (1-4 and 8) and six undescribed isoflavones, vatairenones C-H( 5-7 and 9-11). All isoflavones are prenylated in position C-8, displaying either chain-prenylated (1-7) or ring-closed forms (8-11). The most bioactive compound (3) exhibited in vitro activity against clinically relevant bacteria and fungi with IC50 values ranging from 6.8 to 26.9 μM. Due to its broad antimicrobial activity and low general toxicity, compound 3 is a potential lead compound for structural modifications. The results of the present study support the ethnomedicinal use of V. guianensis in the treatment of dermatological disorders. 1H NMR spectra of some of the isolated compounds showed intricate signal patterns, which might explain repeated errors in assigning the correct structure of the isoflavonoid B-ring in the literature and which we resolved by higher order spectra simulations. 650 $aFabaceae 650 $aMedicinal plants 650 $aPlanta Medicinal 700 1 $aPÉREZ, M. G 700 1 $aWENZEL-STORJOHANN, A. 700 1 $aBEZERRA, R. M. 700 1 $aSEGOVIA, J. F. O. 700 1 $aGIRRESER, U. 700 1 $aKANZAKI, I. 700 1 $aTASDEMIR, D. 773 $tJournal of Natural Products$gv. 85, p. 927-935, 2022.
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Registro original: |
Embrapa Amapá (CPAF-AP) |
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
Data corrente: |
23/03/2004 |
Data da última atualização: |
02/12/2022 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
VALE, R.; CHAVES, M. M.; CARVALHO, C. J. R.; MAROCO, J.; ALMEIDA, S.; GRACE, J.; PEREIRA, J. S.; MEIR, P. |
Afiliação: |
INSTITUTO SUPERIOR DE AGRONOMIA; INSTITUTO SUPERIOR DE AGRONOMIA / INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA; CLAUDIO JOSE REIS DE CARVALHO, CPATU; INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA; MPEG; UNIVERSITY OF EDINBURGH; INSTITUTO SUPERIOR DE AGRONOMIA; UNIVERSITY OF EDINBURGH. |
Título: |
Drought in an E. amazonian rain forest: effects of the exclusion of rainfall from soil on leaf gas exchange. |
Ano de publicação: |
2002 |
Fonte/Imprenta: |
In: CONFERÊNCIA CIENTÍFICA INTERNACIONAL DO LBA, 2., 2002, Manaus. Resumos. Manaus: LBA, 2002. Não paginado. |
Idioma: |
Inglês |
Thesagro: |
Fisiologia Vegetal; Seca. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/101550/1/5322.pdf
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Marc: |
LEADER 00687nam a2200205 a 4500 001 1405335 005 2022-12-02 008 2002 bl uuuu u00u1 u #d 100 1 $aVALE, R. 245 $aDrought in an E. amazonian rain forest$beffects of the exclusion of rainfall from soil on leaf gas exchange.$h[electronic resource] 260 $aIn: CONFERÊNCIA CIENTÍFICA INTERNACIONAL DO LBA, 2., 2002, Manaus. Resumos. Manaus: LBA, 2002. Não paginado.$c2002 650 $aFisiologia Vegetal 650 $aSeca 700 1 $aCHAVES, M. M. 700 1 $aCARVALHO, C. J. R. 700 1 $aMAROCO, J. 700 1 $aALMEIDA, S. 700 1 $aGRACE, J. 700 1 $aPEREIRA, J. S. 700 1 $aMEIR, P.
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Embrapa Amazônia Oriental (CPATU) |
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