Data/hora: 05/06/2024 05:29:33

Biblioteca(s): 	Embrapa Agricultura Digital.	
Data corrente: 	23/06/2009	
Data da última atualização: 	15/01/2020	
Autoria: 	CASTRO, A. de; FRONZA, C. F.; GIACHETTO, P. F.; ALVES, D.	
Afiliação: 	ALEXANDRE DE CASTRO, CNPTIA; CARLOS FREDERICO FRONZA, UNIFESP; POLIANA FERNANDA GIACHETTO, CNPTIA; DOMINGOS ALVES, UNIFESP, USP.	
Título: 	Influence of antigenic mutations in time evolution of the immune memory - a dynamic modeling.	
Ano de publicação: 	2009	
Fonte/Imprenta: 	Lecture Notes in Computer Science, v. 5676, p. 133-142.	
DOI: 	10.1007/978-3-642-03223-3_12	
Idioma: 	Inglês	
Notas: 	Proceedings of the 4th Brazilian Symposium on Bioinformatics, 2009, held in Porto Alegre, Brazil, in July 2009.	
Conteúdo: 	In this paper, we study the behavior of immune memory against antigenic mutation. Using a dynamic model proposed in previous studies, we have performed simulations of several inoculations, where in each virtual sample the viral population undergoes mutations. Our results suggest that the sustainability of the immunizations is dependent on viral variability and that the memory lifetimes are not random, what contradicts what was suggested by recent works. We show that what may cause an apparent random behavior of the immune memoory is the antigenic variability.	
Palavras-Chave: 	Anticorpos; B-cell evolution; Evolução de célula-B; Immune memory; Memória imunológica; Modelagem; Modelo dinâmico; Mutação antigênica; Mutação viral; Viral mutation.	
Thesagro: 	Imunização; Simulação.	
Thesaurus Nal: 	Models.	
Categoria do assunto: 	X Pesquisa, Tecnologia e Engenharia	
Registro original: 	Embrapa Agricultura Digital (CNPTIA)	
Exemplares: 	CNPTIA - (13163-1) - UPC - AP - PP -  -  - 2009.00066 - DES
CNPTIA - (13163-2) - UPC - AP - DD -  -  -  - DIS