Data/hora: 03/06/2024 10:54:59

Biblioteca(s): | Embrapa Pantanal.
Data corrente: | 12/07/1996
Data da última atualização: | 12/07/1996
Autoria: | GERKEN, S. E.; MOTA-SANTOS, T.A.; VAZ, N. M.; CORREA-OLIVEIRA, R.; SILVA, W. D. da; GAZZINELLI, G.
Título: | Recovery of schistosomula of Schistosoma mansoni from mouse skin: involvement of mast cells and vasoactive amines.
Ano de publicação: | 1984
Fonte/Imprenta: | Brazilian Journal of Medical and Biological Research, v.17, p.301-307, 1984.
Idioma: | Inglês

Conteúdo:

1. Normal and S. mansoni-infected mice were exposed to the penetration of 250-350        cercariae through one ear .Two days later, when the ear was removed and chopped, 30 to 50% more schistosomula were recovered from the ears of normal mice than from the ears of infected (immune ) mice.
2. Administration of cyproheptadine, a histamine-serotonin antagonist (2 mg/kg), 30 min
before challenge infection rendered immune mice indistinguishable from normal rnice.
3. Partial depletion of histamine by pretreatment with compound 48-80, a histarnime releaser (1 mg/kg) 2 days before challenge infection increased the numbers of schistosomula recovered from the ears of both normal and immune mice.
4. These results are interpreted to mean that vasoactive amines released by skin mast cells play an important role in hindering the viable passage of schistosomula through the skin of normal and immune mice.

Palavras-Chave: | Acquired resistance; Celula de mastro; Mast cell; Mouse skin; Pele de rato; Resistencia adquerida.
Thesagro: | Imunidade; Schistosoma Mansoni.
Thesaurus Nal: | anaphylaxis; cyproheptadine; immunity.
Categoria do assunto: | --
Registro original: | Embrapa Pantanal (CPAP)
Exemplares: | CPAP - (32753-1) - ADD - SP - -- - SP3122 -  - 3122 - DIS