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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Pecuária Sudeste; Embrapa Pecuária Sul. |
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Data corrente: |
25/03/2024 |
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Data da última atualização: |
25/03/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARVALHO, W. A.; GASPAR, E. B.; DOMINGUES, R.; REGITANO, L. C. de A.; CARDOSO, F. F. |
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Afiliação: |
WANESSA ARAUJO CARVALHO, CNPGL; EMANUELLE BALDO GASPAR, CNPGL; ROBERT DOMINGUES, CNPGL; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; FERNANDO FLORES CARDOSO, CPPSUL. |
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Título: |
Genetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle: a systems biology perspective. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Mammalian Genome, 2024. |
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DOI: |
https://doi.org/10.1007/s00335-024-10030-x |
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Idioma: |
Inglês |
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Notas: |
First online. |
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Conteúdo: |
Approximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle. MenosApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates ... Mostrar Tudo |
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Thesagro: |
Bovino; Carrapato; Doença Animal; Parasitismo; Resistência. |
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Thesaurus Nal: |
Amber disease; Parasitism; Ticks. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02431naa a2200289 a 4500
001 2163111
005 2024-03-25
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s00335-024-10030-x$2DOI
100 1 $aCARVALHO, W. A.
245 $aGenetic factors underlying host resistance to Rhipicephalus microplus tick infestation in Braford cattle$ba systems biology perspective.$h[electronic resource]
260 $c2024
500 $aFirst online.
520 $aApproximately 80% of the world's cattle are raised in regions with a high risk of tick-borne diseases, resulting in significant economic losses due to parasitism by Rhipicephalus(Boophilus)microplus. However, the lack of a systemic biology approach hampers a comprehensive understanding of tick-host interactions that mediate tick resistance phenotypes. Here, we conducted a genome-wide association study (GWAS) of 2933 Braford cattle and found 340 single-nucleotide polymorphisms (SNPs) associated with tick counts. Gene expression analyses were performed on skin samples obtained from previously tick-exposed heifers with extremely high or low estimated breeding values for R.microplus counts. Evaluations were performed both before and after artificial infestation with ticks. Differentially expressed genes were found within 1-Mb windows centered at significant SNPs from GWAS. A total of 330 genes were related to the breakdown of homeostasis that was induced by larval attachment to bovine skin. Enrichment analysis pointed to a key role of proteolysis and signal transduction via JAK/STAT, NFKB and WNT/beta catenin signaling pathways. Integrative analysis on matrixEQTL revealed two cis-eQTLs and four significant SNPs in the genes peptidylargininedeiminasetypeIV (PADI4) and LOC11449251. The integration of genomic data from QTL maps and transcriptome analyses has identified a set of twelve key genes that show significant associations with tick loads. These genes could be key candidates to improve the accuracy of genomic predictions for tick resistance in Braford cattle.
650 $aAmber disease
650 $aParasitism
650 $aTicks
650 $aBovino
650 $aCarrapato
650 $aDoença Animal
650 $aParasitismo
650 $aResistência
700 1 $aGASPAR, E. B.
700 1 $aDOMINGUES, R.
700 1 $aREGITANO, L. C. de A.
700 1 $aCARDOSO, F. F.
773 $tMammalian Genome, 2024.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 123 | |
| 21. |  | OLIVEIRA, C. J. de; DOMINGUES, R.; GRANADA, R. L.; MINHO, A. P.; GASPAR, E. B. Ação antibacteriana in vitro de extratos vegetais de plantas do Bioma Pampa. In: SIMPÓSIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA PECUÁRIA SUL, 6., 2016, Bagé. Resumos... Bagé: Embrapa Pecuária Sul, 2016. p. 9. Claudia Cristina Gulias Gomes, editora técnica.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 25. | | GASPAR, E. B.; MINHO, A. P.; SUÑÉ, R. W.; DOMINGUES, R. Caracterização da mastite subclínica em animais das raças Holandesa e Jersey criados a pasto. In: CONGRESSO DE INICIAÇÃO CIENTÍFICA, 25.; CONGRESSO DE EXTENSÃO E CULTURA, 3.; CONGRESSO DE ENSINO DE GRADUAÇÃO, 2.; ENCONTRO DE PÓS-GRADUAÇÃO, 18., 2016, Pelotas. Conhecimento, sociedade e diversidade: anais. Pelotas: UFPEL, 2016. ENPOS.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 27. | | SOARES, S. M.; GASPAR, E. B.; SUÑÉ, R. W.; VIEIRA, M. I. B.; MINHO, A. P. Correlação entre testes laboratoriais e a campo para detecção de mastite subclínica em rebanhos leiteiros. Anais do Salão Internacional de Ensino, Pesquisa e Extensão, Bagé, v. 8, n. 4, 2016.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 32. | | BAUMHARDT, A. B.; ANDRADE, L. G. de; DOMINGUES, R.; GASPAR, E. B. Avaliação de toxicidade do extrato aquoso de Daphnopsis racemosa contra células de mamíferos. In: SIMPÓSIO DE INICIAÇÃO CIENTÍFICA DA EMBRAPA PECUÁRIA SUL, 8., 2018, Bagé. Resumos... Bagé: Embrapa Pecuária Sul, 2018. p. 17. (Embrapa Pecuária Sul. Eventos técnicos & científicos, 1). Fernando Flores Cardoso, Daniel Portella Montardo, José Carlos Ferrugem Moraes, Marcos Flávio Silva Borba, Sandro da Silva Camargo, editores técnicos.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 34. | | SANTOS, P. A. dos; DOMINGUES, R.; MINHO, A.; GASPAR, E. B.; SUÑÉ, R. W. Avaliação de dois métodos de predição de peso em bezerras leiteiras. In: CONGRESSO INTERNACIONAL DO LEITE, 13.; WORKSHOP DE POLÍTICAS PÚBLICAS, 13.; SIMPÓSIO DE SUSTENTABILIDADE DA ATIVIDADE LEITEIRA, 14., 2015, Porto Alegre. Anais... Brasília, DF: Embrapa, 2015. 1 CD-ROM. (Embrapa Gado de Leite. Documentos, 184.). Editores Técnicos: Paulo do Carmo Martins, Gilberto Antônio Piccinini, Ernesto Ênio Budke Krug, Marne Sidney de Paula Moreira, Carlos Eugênio Martins, Oreno Ardêmio Heineck, Marcelo Henrique Otenio, Leonardo Dornelles de Dorneles,...| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 35. | | DE GASPARI, E.; FABIANA, M. R.; GASPAR, E. B.; ROSETTI, A. S. Study of the antigenic cross-reactivity between Neisseria meningitidis and commensal Neisseria species using (DDA-BF) as adjuvant. In: EUROPEAN CONGRESS OF IMMUNOLOGY, 3., 2012, Glasgow. A healthier future through research, education and innovation: abstracts. London: Kenes, 2012. Publicado em Immunology, v. 137, p. 660, 2012, suppl. 1. Também publicado no 6th VACCINE & INTERNATIONAL SOCIETY FOR VACCINES CONGRESS, 2012, Shanghai.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| Registros recuperados : 123 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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