Data/hora: 21/06/2024 04:25:45

Biblioteca(s): 	Embrapa Pantanal.	
Data corrente: 	19/05/1999	
Data da última atualização: 	19/05/1999	
Autoria: 	BROWN, S. J.; GALLI, S. J.; GLEICH, G. J.; ASKENASE, P. W.	
Título: 	Ablation of immunity to Amblyomma americanum by anti-basophil serum: cooperation between basophils and eosinophils in expression of immunity to ectoparasites (ticks) in guinea pigs.	
Ano de publicação: 	1982	
Fonte/Imprenta: 	Journal of Immunology, v.129, n.2, p.790-796, 1982.	
Idioma: 	Inglês	
Conteúdo: 	Basophils infiltrate the skin and other tissues as part of T lymphocyte and/or antibody-mediated immune responses to certain protein antigens, viruses, tumors, and parasites. Although basophils may comprise a significant fraction of leukocytes in these reactions, their precise role has been poorly understood. Guinea pigs expressing acquired
immunity to the tick Amblyomma americanum develop basophil- and eosinophil-rich cutaneous inflamatory responses at tick feeding sites, and tick rejection is associated with extensive local basophil degranulation. We report that a specific anti-basophil serum 
(ABS) eliminated basophils at tick feeding sites and abolished immunity to A. Americanum. 
ABS does not react with eosinophils; however, ABS-treated animals had diminished eosinophils at tick feeding sites, perhaps because these sites were deficient in basophil-
derived eosinophil-chemotactic factor. AES treatment markedly reduced feeding site eosinophils, did not affect basophil levels, and partially impaired tick resistence. Taken fogether, our experiments suggest cooperation between basophils and eosinophils in the expression of immunity to ticks in guinea pigs. 

Palavras-Chave: 	Tick.	
Thesagro: 	Carrapato; Imunologia; Parasitologia.	
Thesaurus Nal: 	immunology; parasitology.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Pantanal (CPAP)	
Exemplares: 	CPAP - (39075-1) - ADD - SP - -- - SP5227 -  - 5227 - DIS