Data/hora: 15/06/2024 04:39:12

Biblioteca(s): | Embrapa Gado de Leite.
Data corrente: | 21/08/2021
Data da última atualização: | 21/08/2021
Autoria: | SILVA, N. P. da; PEREIRA, E. do C. R. L.; DUARTE, L. M.; FREITAS, J. C. de O.; ALMEIDA, C. G. de; SILVA, T. P. da; MELO, R. C. N.; APOLONIO, A. C. M.; OLIVEIRA, M. A. L. de; BRANDAO, H. de M.; PITTELLA, F.; FABRI, R. L.; TAVARES, G. D.; PINTO, P. de F.
Afiliação: | NATALIA PRADO DA SILVA, Universidade Federal de Juiz de Fora; ELOA DO CARMO RAPOZO LAVINAS PEREIRA, Universidade Federal de Juiz de Fora; LUCAS MATTOS DUARTE, Universidade Federal de Juiz de Fora; JHAMINE CAROLINE DE OLIVEIRA FREITAS, Universidade Federal de Juiz de Fora; CAMILA GUIMARAES DE ALMEIDA; THIAGO PEREIRA DA SILVA, Universidade Federal de Juiz de Fora; ROSSANA C. N. MELO, Universidade Federal de Juiz de Fora; ANA CAROLINA MORAIS APOLONIO, Universidade Federal de Juiz de Fora; MARCONE AUGUSTO LEAL DE OLIVEIRA, Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; FREDERICO PITTELLA, Universidade Federal de Juiz de Fora; RODRIGO LUIZ FABRI, Universidade Federal de Juiz de Fora; GUILHERME DINIZ TAVARES, Universidade Federal de Juiz de Fora; PRISCILA DE FARIA PINTO, Universidade Federal de Juiz de Fora.
Título: | Improved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(ε-caprolactone) core-shell nanocapsules.
Ano de publicação: | 2020
Fonte/Imprenta: | Colloids and Surfaces B: Biointerfaces, v. 196, 111371, 2020.
DOI: | https://doi.org/10.1016/j.colsurfb.2020.111371
Idioma: | Inglês
Conteúdo: | The purpose of this study was to develop tea tree oil (TTO)-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules (NC-TTO-Ch) aiming the topical acne treatment. TTO was analyzed by gas chromatographymass spectrometry, and nanocapsules were characterized regarding mean particle size (Z-average), polydispersity index (PdI), zeta potential (ZP), pH, entrapment efficiency (EE), morphology by Atomic Force Microscopy (AFM), and anti-Cutibacterium acnes activity. The main constituents of TTO were terpinen-4-ol (37.11 %), ?-terpinene (16.32 %), ?-terpinene (8.19 %), ?-cimene (6.56 %), and ?-terpineol (6.07 %). NC-TTO-Ch presented Z-average of 268.0 ± 3.8 nm and monodisperse size distribution (PdI < 0.3). After coating the nanocapsules with chitosan, we observed an inversion in ZP to a positive value (+31.0 ± 1.8 mV). This finding may indicate the presence of chitosan on the nanocapsules? surface, which was corroborated by the AFM images. In addition, NC-TTO-Ch showed a slightly acidic pH (~5.0), compatible with topical application. The EE, based on Terpinen-4-ol concentration, was approximately 95 %. This data suggests the nanocapsules? ability to reduce the TTO volatilization. Furthermore, NC-TTO-Ch showed significant anti-C. acnes activity, with a 4× reduction in the minimum inhibitory concentration, compared to TTO and a decrease in C. acnes cell viability, with an increase in the percentage of dead cells (17 %) compared to growth control (6.6 %) and TTO (9.7 %). Therefore, chitosan-poly(?-caprolactone) core-shell nanocapsules are a promising tool for TTO delivery, aiming at the activity against C. acnes for the topical acne treatment.
Palavras-Chave: | Acne vulgaris; Core-shell nanocapsules; Nanocápsula; Quitosana-poli.
Thesagro: | Árvore.
Thesaurus Nal: | Chitosan; Tea tree oil.
Categoria do assunto: | F Plantas e Produtos de Origem Vegetal
Registro original: | Embrapa Gado de Leite (CNPGL)
Exemplares: | CNPGL - (25257-1) - UPC - AP - DD -  -  -  - DIS