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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves; Embrapa Unidades Centrais. |
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Data corrente: |
11/09/2023 |
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Data da última atualização: |
11/09/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
HAACH, V.; BASTOS, A. P. A.; GAVA, D.; FONSECA, F. M. da; MORES, M. A. Z.; COLDEBELLA, A.; FRANCO, A. C.; SCHAEFER, R. |
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Afiliação: |
VANESSA HAACH, Universidade Federal do Rio Grande do Sul; ANA PAULA ALMEIDA BASTOS, CNPSA; DANIELLE GAVA, CNPSA; FRANCISCO NOE DA FONSECA, GEM; MARCOS ANTONIO ZANELLA MORES, CNPSA; ARLEI COLDEBELLA, CNPSA; ANA CLÁUDIA FRANCO, Universidade Federal do Rio Grande do Sul; REJANE SCHAEFER, CNPSA. |
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Título: |
A polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Virology Journal, v. 20, article number 181, 2023. |
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DOI: |
https://doi.org/10.1186/s12985-023-02153-5 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Background: Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses. Methods: This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs. Results: A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies and virus-neutralizing activity. Furthermore, it induced a significant maturation of macrophages, and proliferation of B lymphocytes, effector and central memory CD4+ and CD8+ T cells, and CD8+ T lymphocytes producing interferon-γ. Also, the vaccine demonstrated potential to confer long-lasting immunity until the market age of pigs and proved to be safe and non-cytotoxic to pigs. Conclusions: This virosome platform allows flexibility to adjust the vaccine content to reflect the diversity of circulating IAVs in swine in Brazil. The vaccination of pigs may reduce the impact of the disease on swine production and the risk of swine-to-human transmission. |
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Palavras-Chave: |
Cellular immunity; Virosomal vaccine. |
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Thesagro: |
Imunidade; Suíno; Vacina. |
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Thesaurus Nal: |
Humoral immunity; Influenza A virus; Swine. |
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Categoria do assunto: |
--
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1156557/1/final10093.pdf
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Marc: |
LEADER 02316naa a2200313 a 4500
001 2156557
005 2023-09-11
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/s12985-023-02153-5$2DOI
100 1 $aHAACH, V.
245 $aA polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs.$h[electronic resource]
260 $c2023
520 $aAbstract: Background: Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses. Methods: This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs. Results: A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies and virus-neutralizing activity. Furthermore, it induced a significant maturation of macrophages, and proliferation of B lymphocytes, effector and central memory CD4+ and CD8+ T cells, and CD8+ T lymphocytes producing interferon-γ. Also, the vaccine demonstrated potential to confer long-lasting immunity until the market age of pigs and proved to be safe and non-cytotoxic to pigs. Conclusions: This virosome platform allows flexibility to adjust the vaccine content to reflect the diversity of circulating IAVs in swine in Brazil. The vaccination of pigs may reduce the impact of the disease on swine production and the risk of swine-to-human transmission.
650 $aHumoral immunity
650 $aInfluenza A virus
650 $aSwine
650 $aImunidade
650 $aSuíno
650 $aVacina
653 $aCellular immunity
653 $aVirosomal vaccine
700 1 $aBASTOS, A. P. A.
700 1 $aGAVA, D.
700 1 $aFONSECA, F. M. da
700 1 $aMORES, M. A. Z.
700 1 $aCOLDEBELLA, A.
700 1 $aFRANCO, A. C.
700 1 $aSCHAEFER, R.
773 $tVirology Journal$gv. 20, article number 181, 2023.
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Registro original: |
Embrapa Suínos e Aves (CNPSA) |
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Tipo/Formato |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
22/10/2014 |
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Data da última atualização: |
22/12/2022 |
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Tipo da produção científica: |
Artigo em Anais de Congresso |
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Autoria: |
TIZIOTO, P. C.; GASPARIN, G.; COUTINHO, L. L.; MOURÃO, G. B.; MUDADU, M. de A.; SOUZA, M. M.; MALAGO JUNIOR, W.; DONATONI, F. A. B.; TULLIO, R. R.; NASSU, R. T.; REGITANO, L. C. de A. |
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Afiliação: |
POLYANA C. TIZIOTO, Universidade Federal de São Carlos; GUSTAVO GASPARIN, Universidade de São Paulo/ESALQ; LUIZ L. COUTINHO, Universidade de São Paulo/ESALQ; G. B. MOURÃO, Universidade de São Paulo/ESALQ; MAURICIO DE ALVARENGA MUDADU, CPPSE; M. M. SOUZA, Universidade Federal de São Carlos; WILSON MALAGO JUNIOR, CPPSE; FLAVIA ALINE BRESSANI DONATONI, CPPSE; RYMER RAMIZ TULLIO, CPPSE; RENATA TIEKO NASSU, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
MyoD1 expression levels affect meat tenderness in Nellore beef cattle. |
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Ano de publicação: |
2014 |
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Fonte/Imprenta: |
In: WORLD CONGRESS OF GENETICS APPLIED TO LIVESTOK PRODUCTION, 10., 2014, Vancouver. Proceedings... Vancouver: American Society of animal Science, 2014. |
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Páginas: |
3 p. |
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Idioma: |
Inglês |
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Conteúdo: |
The MyoD1 gene play a key role in skeletal muscle differentiation through the regulation of muscle-specific genes expression. |
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Palavras-Chave: |
Gene expres; QPCR; Shear force. |
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Thesagro: |
Bos Indicus. |
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Categoria do assunto: |
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/110389/1/PROCI-2014.00079.pdf
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Marc: |
LEADER 01019nam a2200289 a 4500
001 1998063
005 2022-12-22
008 2014 bl uuuu u00u1 u #d
100 1 $aTIZIOTO, P. C.
245 $aMyoD1 expression levels affect meat tenderness in Nellore beef cattle.$h[electronic resource]
260 $aIn: WORLD CONGRESS OF GENETICS APPLIED TO LIVESTOK PRODUCTION, 10., 2014, Vancouver. Proceedings... Vancouver: American Society of animal Science$c2014
300 $a3 p.
520 $aThe MyoD1 gene play a key role in skeletal muscle differentiation through the regulation of muscle-specific genes expression.
650 $aBos Indicus
653 $aGene expres
653 $aQPCR
653 $aShear force
700 1 $aGASPARIN, G.
700 1 $aCOUTINHO, L. L.
700 1 $aMOURÃO, G. B.
700 1 $aMUDADU, M. de A.
700 1 $aSOUZA, M. M.
700 1 $aMALAGO JUNIOR, W.
700 1 $aDONATONI, F. A. B.
700 1 $aTULLIO, R. R.
700 1 $aNASSU, R. T.
700 1 $aREGITANO, L. C. de A.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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