Data/hora: 26/05/2024 16:20:51

Biblioteca(s): 	Embrapa Caprinos e Ovinos.	
Data corrente: 	16/06/2017	
Data da última atualização: 	16/06/2017	
Autoria: 	LOBLEY, G. E.; CONNELL, A.; BUCHAN, V.; SKENE, P. A.; FLETCHER, J. M.	
Título: 	Administration of testosterone to wether lambs: effects on protein and energy metabolism and growth hormone status.	
Ano de publicação: 	1987	
Fonte/Imprenta: 	Journal of Endocrinology, v. 115, n. 3, p. 439-446, Dec. 1987.	
DOI: 	10.1677/joe.0.1150439	
Idioma: 	Inglês	
Conteúdo: 	Abstract: The effects of episodic infusion of testosterone into the vascular system on energy expenditure, nitrogen retention and whole body protein synthesis (determined from [1-14C]leucine kinetics) were studied in castrated male lambs under conditions of controlled food intake. Comparisons were made between a 10-day control period and a 10-day treatment period for each lamb. Infusion of testosterone produced a significant increase in heat production, but the magnitude (198 kJ/day, +2.5%) was less than the differences in energy expenditure expected between entire and castrated male ruminants. The retention of nitrogen improved by 1.24 g/day (+22%) in response to the administration of androgen, and this was accompanied by a decrease in amino acid oxidation. Total protein synthesis also declined, and the anabolic nature of testosterone supply must, therefore, be effected through a reduction in the breakdown of protein, the mechanism being similar to that proposed for certain anabolic steroids and the beta-agonist, clenbuterol. Contrary to other reports, the presence of testosterone had no effect on the plasma concentration of GH.	
Palavras-Chave: 	Drug effects; Growth Hormone.	
Thesaurus Nal: 	Biosynthesis; Energy Metabolism; Leucine; Nitrogen; Pharmacokinetics; Pharmacology; Proteins; Sheep; Testosterone.	
Categoria do assunto: 	L Ciência Animal e Produtos de Origem Animal	
Registro original: 	Embrapa Caprinos e Ovinos (CNPC)	
Exemplares: 	CNPC - (33868-1) - ADD - AP - PP -  -  -  - DIS