Data/hora: 04/06/2024 18:09:38

Biblioteca(s): 	Embrapa Unidades Centrais.	
Data corrente: 	10/03/2016	
Data da última atualização: 	10/03/2016	
Autoria: 	HEADLEY, S. A.; BRACARENSE, A. P. F. R. L.; OLIVEIRA, V. H. S.; QUEIROX, G. R.; OKANO, W.; ALFIERI, A. F.; FLAIBAN, K. K. M.; LISBÔA, J. A. N.; ALFIERI, A. A.	
Afiliação: 	SELWYN A. HEADLEY, UEL; ANA PAULA F. R. L. BRACARENSE, UEL; VICTOR H. S. OLIVEIRA, UEL; GUSTAVO R. QUEIROZ, UEL; WERNER OKANO, Universidade Norte do Paraná; ALICE F. ALFIERI, UEL; KARINA K. M. C. FLAIBAN, UEL; JÚLIO A. N. LISBÔA, UEL; AMAURI A. ALFIERI, UEL.	
Título: 	Histophilus somni-induced thrombotic meningoencephalitis in cattle from northern Paraná, Brazil.	
Ano de publicação: 	2015	
Fonte/Imprenta: 	Pesquisa Veterinária Brasileira, Brasília, DF, v. 35. n. 4, p. 329-336, abr. 2015.	
Idioma: 	Português	
Conteúdo: 	Thrombotic meningoencephalitis (TME) is a fatal neurological disease of cattle, predominantly from North America, that is caused by Histophilus somni with sporadic descriptions from other countries. This manuscript describes the occurrence of spontaneous TME in cattle from northern Paraná, Brazil. Most cattle had acute neurological manifestations characteristic of brain dysfunction. Hematological and cerebrospinal fluid analyses were not suggestive of bacterial infections of the brain. Histopathology revealed meningoencephalitis with vasculitis and thrombosis of small vessels that contained discrete neutrophilic and/or lymphocytic infiltrates admixed with fibrin at the brainstem, cerebral cortex, and trigeminal nerve ganglion of all animals. All tissues from the central nervous system used during this study were previously characterized as negative for rabies virus by the direct immunofluorescence assay. PCR and RT-PCR assays investigated the participation of infectious agents associated with bovine neurological disease by targeting specific genes of H. somni, Listeria monocytogenes, bovine herpesvirus -1 and -5, bovine viral diarrhea virus, and ovine herpesvirus-2. PCR and subsequent sequencing resulted in partial fragments of the 16S rRNA gene of H. somni from brain sections of all animals with histopathological diagnosis of TME; all other PCR/RT-PCR assays were negative. These findings confirmed the participation of H. somni in the neuropathological disease observed in these animals, extend the geographical distribution of this disease, and support previous findings of H. somni from Brazil.	
Palavras-Chave: 	Histofilose; Histophilosis; Histophilus somni; Meningoencefalite trombótica; Molecular diagnostics; Neuropatologia; Sistema nervoso central; Thrombotic meningoencephalitis.	
Thesagro: 	Bovino; Doença.	
Thesaurus Nal: 	Cattle diseases; Central nervous system; Neuropathology.	
Categoria do assunto: 	--	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/item/140966/1/Histophilus-somni-induced.pdf	
Registro original: 	Embrapa Unidades Centrais (AI-SEDE)	
Exemplares: 	AI-SEDE - (59093-1) - UPE - AP - DD -  -  -  - DIS