Data/hora: 16/06/2024 06:04:07

Biblioteca(s): | Embrapa Meio Ambiente.
Data corrente: | 28/11/2022
Data da última atualização: | 28/11/2022
Autoria: | REIS, A. C. C.; JORGE, B. C.; PASCHALINI, B. R.; BUENO, J. N.; STEIN, J.; MOREIRA, S. da S.; MANOEL, B. de M.; FERNANDES, G. S. A.; HISANO, H.; ARENA, A. C.
Afiliação: | ANA CAROLINA CASALI REIS, UNIVERSIDADE ESTADUAL PAULISTA; BÁRBARA CAMPOS JORGE, UNIVERSIDADE ESTADUAL PAULISTA; BEATRIZ RIZZO PASCHOALINI, UNIVERSIDADE ESTADUAL PAULISTA; JÉSSICA NOGUEIRA BUENO, UNIVERSIDADE ESTADUAL PAULISTA; JULIA STEIN, UNIVERSIDADE ESTADUAL PAULISTA; SUYANE DA SILVA MOREIRA, UNIVERSIDADE ESTADUAL PAULISTA; BEATRIZ DE MATOS MANOEL, UNIVERSIDADE ESTADUAL PAULISTA; GLAURA SCANTAMBURLO ALVES FERNANDES, UNIVERSIDADE ESTADUAL DE LONDRINA; HAMILTON HISANO, CNPMA; ARIELLE CRISTINA ARENA, UNIVERSIDADE ESTADUAL PAULISTA.
Título: | Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats.
Ano de publicação: | 2022
Fonte/Imprenta: | Drug and Chemical Toxicology, 2022.
ISSN: | 0148-0545
DOI: | https://doi.org/10.1080/01480545.2022.2105864
Idioma: | Inglês
Notas: | On-line first.
Conteúdo: | Abstract: Since studies on the reproductive consequences after the exposure to environmentally relevant doses of Benzo(a)pyrene (BaP) during critical stages of development are scarce, this study evaluated female reproductive parameters of adult rats exposed to a low dose of BaP during the juvenile phase. Female rats (Post-natal 21) were treated with BaP (0 or 0.1 µg/kg/day; gavage) for 21 consecutive days. During the treatment, no clinical signs of toxicity were observed. Nevertheless, the ages of vaginal opening and first estrus were anticipated by the BaP-exposure. At the sexual maturity, the juvenile exposure compromised the sexual behavior, as well as the placental efficiency, follicle stimulating hormone levels, placenta histological analysis, and ovarian follicle count. A decrease in erythrocyte, platelet, and lymphocyte counts also was observed in the exposed-females. Moreover, the dose of BaP used in this study was not able to produce estrogenic activity in vivo. These data showed that juvenile BaP-exposure, at environmentally relevant dose, compromised the female reproductive system, possibly by an endocrine deregulation; however, this requires further investigation.
Palavras-Chave: | Endocrine disruptor; Hidrocarboneto policíclico aromático; Juvenile period.
Thesagro: | Aparelho Reprodutor; Fêmea; Hidrocarboneto; Impacto Ambiental; Rato; Reprodução Animal.
Thesaurus Nal: | Benzo(a)pyrene; Female fertility; Female reproductive system; Health effects assessments; Polycyclic aromatic hydrocarbons; Puberty; Rats.
Categoria do assunto: | H Saúde e Patologia
Registro original: | Embrapa Meio Ambiente (CNPMA)
Exemplares: | CNPMA - (17260-1) - UPC - AP - DD -  -  -  - DIS