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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
25/07/2022 |
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Data da última atualização: |
25/07/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SANTOS, C. G. dos; SOUSA, M. F.; VIEIRA, J. I. G.; MORAIS, L. R. de; FERNANDES, A. A. S.; LITTIERE, T. de O.; OTTO, P. I.; MACHADO, M. A.; SILVA, M. V. G. B.; BONAFÉ, C. M.; MAGALHÃES, A. F. B.; VERARDO, L. L. |
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Afiliação: |
CASSIANE GOMES DOS SANTOS, Universidade Federal dos Vales do Jequitinhonha e Mucuri; MARIELE FREITAS SOUSA, Universidade Federal dos Vales do Jequitinhonha e Mucuri; JOÃO INÁCIO GOMES VIEIRA, Universidade Federal dos Vales do Jequitinhonha e Mucuri; LUANA RAFAELA DE MORAIS, Universidade Federal dos Vales do Jequitinhonha e Mucuri; ALINE AUXILIADORA SILVA FERNANDES, Universidade Federal dos Vales do Jequitinhonha e Mucuri; THAYSSA DE OLIVEIRA LITTIERE, Universidade Estadual Paulista "Júlio de Mesquita Filho"; PAMELA ITAJARA OTTO, Universidade Federal de Santa Maria; MARCO ANTONIO MACHADO, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; CRISTINA MOREIRA BONAFÉ, Universidade Federal dos Vales do Jequitinhonha e Mucuri; ANA FABRÍCIA BRAGA MAGALHÃES, Universidade Federal dos Vales do Jequitinhonha e Mucuri; LUCAS LIMA VERARDO, Universidade Federal dos Vales do Jequitinhonha e Mucuri. |
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Título: |
Candidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Journal of Applied Animal Research, v. 50, n. 1, p. 460-470, 2022. |
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DOI: |
https://doi.org/10.1080/09712119.2022.2096035 |
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Idioma: |
Inglês |
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Conteúdo: |
Rhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5' UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses. |
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Palavras-Chave: |
Ectoparasita; Sistema imunológico. |
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Thesagro: |
Bovino; Carne; Carrapato; Genoma; Hospedeiro Animal. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1144893/1/Candidate-genes-for-tick-resistance-in-cattle.pdf
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Marc: |
LEADER 02437naa a2200349 a 4500
001 2144893
005 2022-07-25
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1080/09712119.2022.2096035$2DOI
100 1 $aSANTOS, C. G. dos
245 $aCandidate genes for tick resistance in cattle$ba systematic review combining post-GWAS analyses with sequencing data.$h[electronic resource]
260 $c2022
520 $aRhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5' UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses.
650 $aBovino
650 $aCarne
650 $aCarrapato
650 $aGenoma
650 $aHospedeiro Animal
653 $aEctoparasita
653 $aSistema imunológico
700 1 $aSOUSA, M. F.
700 1 $aVIEIRA, J. I. G.
700 1 $aMORAIS, L. R. de
700 1 $aFERNANDES, A. A. S.
700 1 $aLITTIERE, T. de O.
700 1 $aOTTO, P. I.
700 1 $aMACHADO, M. A.
700 1 $aSILVA, M. V. G. B.
700 1 $aBONAFÉ, C. M.
700 1 $aMAGALHÃES, A. F. B.
700 1 $aVERARDO, L. L.
773 $tJournal of Applied Animal Research$gv. 50, n. 1, p. 460-470, 2022.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Milho e Sorgo. Para informações adicionais entre em contato com cnpms.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Milho e Sorgo. |
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Data corrente: |
03/08/2004 |
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Data da última atualização: |
05/06/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MOTA, F. F. da; GOMES, E. A.; PAIVA, E.; ROSADO, A. S.; SELDIN, L. |
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Afiliação: |
ELIANE APARECIDA GOMES, CNPMS; EMBRAPA-CNPMS. |
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Título: |
Use of rpoB gene analysis for identification of nitrogen-fixing Paenibacillus species as an alternative to the 16S rRNA gene. |
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Ano de publicação: |
2004 |
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Fonte/Imprenta: |
Letters in Applied Microbiology, Oxford, v. 39, n. 1, p. 34-40, 2004. |
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Idioma: |
Inglês |
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Conteúdo: |
Aim: To avoid the limitations of 16S rRNA-based phylogenetic analysis for Paenibacillus species, the usefulness of the RNA polymerase beta-subunit encoding gene (rpoB) was investigated as an alternative to the 16S rRNA gene for taxonomic studies. Methods and Results: Partial rpoB sequences were generated for the type strains of eight nitrogen-fixing Paenibacillus species. The presence of only one copy of rpoB in the genome of P. graminis strain RSA19T was demonstrated by denaturing gradient gel electrophoresis and hybridization assays. A comparative analysis of the sequences of the 16S rRNA and rpoB genes was performed and the eight species showed between 91·6-99·1% (16S rRNA) and 77·9-97·3% (rpoB) similarity, allowing a more accurate discrimination between the different species using the rpoB gene. Finally, 24 isolates from the rhizosphere of different cultivars of maize previously identified as Paenibacillus spp. were assigned correctly to one of the nitrogen-fixing species. Conclusions, Significance and Impact of the Study: The data obtained in this study indicate that rpoB is a powerful identification tool, which can be used for the correct discrimination of the nitrogen-fixing species of agricultural and industrial importance within the genus Paenibacillus. |
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Thesagro: |
Gene. |
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Categoria do assunto: |
S Ciências Biológicas |
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Marc: |
LEADER 01861naa a2200181 a 4500
001 1487746
005 2018-06-05
008 2004 bl uuuu u00u1 u #d
100 1 $aMOTA, F. F. da
245 $aUse of rpoB gene analysis for identification of nitrogen-fixing Paenibacillus species as an alternative to the 16S rRNA gene.$h[electronic resource]
260 $c2004
520 $aAim: To avoid the limitations of 16S rRNA-based phylogenetic analysis for Paenibacillus species, the usefulness of the RNA polymerase beta-subunit encoding gene (rpoB) was investigated as an alternative to the 16S rRNA gene for taxonomic studies. Methods and Results: Partial rpoB sequences were generated for the type strains of eight nitrogen-fixing Paenibacillus species. The presence of only one copy of rpoB in the genome of P. graminis strain RSA19T was demonstrated by denaturing gradient gel electrophoresis and hybridization assays. A comparative analysis of the sequences of the 16S rRNA and rpoB genes was performed and the eight species showed between 91·6-99·1% (16S rRNA) and 77·9-97·3% (rpoB) similarity, allowing a more accurate discrimination between the different species using the rpoB gene. Finally, 24 isolates from the rhizosphere of different cultivars of maize previously identified as Paenibacillus spp. were assigned correctly to one of the nitrogen-fixing species. Conclusions, Significance and Impact of the Study: The data obtained in this study indicate that rpoB is a powerful identification tool, which can be used for the correct discrimination of the nitrogen-fixing species of agricultural and industrial importance within the genus Paenibacillus.
650 $aGene
700 1 $aGOMES, E. A.
700 1 $aPAIVA, E.
700 1 $aROSADO, A. S.
700 1 $aSELDIN, L.
773 $tLetters in Applied Microbiology, Oxford$gv. 39, n. 1, p. 34-40, 2004.
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Embrapa Milho e Sorgo (CNPMS) |
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