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Registro Completo |
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
02/12/2009 |
Data da última atualização: |
10/01/2024 |
Tipo da produção científica: |
Artigo de Divulgação na Mídia |
Autoria: |
FARIAS, J. L. de S. |
Afiliação: |
JORGE LUIS DE SALES FARIAS, CNPC. |
Título: |
Estratégias para o desenvolvimento local: utilização das Unidades demonstrativas de carne e leite de caprinos e ovinos e seus derivados como ferramentas inovadoras para a transferência de tecnologias. |
Ano de publicação: |
2009 |
Fonte/Imprenta: |
Portal Ripa. Seção artigos. Disponível em: . Acesso em 02 nov. 2009. |
Idioma: |
Português |
Palavras-Chave: |
Unidades demonstrativas. |
Thesagro: |
Caprinocultura; Ovinocultura; Transferência de Tecnologia. |
Categoria do assunto: |
E Economia e Indústria Agrícola |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/86009/1/Midia-Estrategias-para-o-desenvolvimento.pdf
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Marc: |
LEADER 00688nam a2200145 a 4500 001 1576990 005 2024-01-10 008 2009 bl uuuu u00u1 u #d 100 1 $aFARIAS, J. L. de S. 245 $aEstratégias para o desenvolvimento local$butilização das Unidades demonstrativas de carne e leite de caprinos e ovinos e seus derivados como ferramentas inovadoras para a transferência de tecnologias.$h[electronic resource] 260 $aPortal Ripa. Seção artigos. Disponível em: <http://www.ripa.com.br/index.php?id=1887#>. Acesso em 02 nov. 2009.$c2009 650 $aCaprinocultura 650 $aOvinocultura 650 $aTransferência de Tecnologia 653 $aUnidades demonstrativas
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Embrapa Caprinos e Ovinos (CNPC) |
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Registro Completo
Biblioteca(s): |
Embrapa Florestas. |
Data corrente: |
10/06/2015 |
Data da última atualização: |
02/03/2016 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
VERARDO, L. L.; SILVA, F. F.; VARONA, L.; RESENDE, M. D. V. de; BASTIAANSEN, J. W. M.; LOPES, P. S.; GUIMARÃES, S. E. F. |
Afiliação: |
UFV; UFV; Universidad de Zaragoza; MARCOS DEON VILELA DE RESENDE, CNPF; Wageningen University; UFV; UFV. |
Título: |
Bayesian GWAS and network analysis revealed new candidate genes for number of teats in pigs. |
Ano de publicação: |
2015 |
Fonte/Imprenta: |
Journal of Applied Genetics, v. 56, n. 1, p. 123-132, Feb. 2015. |
DOI: |
10.1007/s13353-014-0240-y |
Idioma: |
Inglês |
Conteúdo: |
The genetic improvement of reproductive traits such as the number of teats is essential to the success of the pig industry. As opposite to most SNP association studies that consider continuous phenotypes under Gaussian assumptions, this trait is characterized as a discrete variable, which could potentially follow other distributions, such as the Poisson. Therefore, in order to access the complexity of a counting random regression considering all SNPs simultaneously as covariate under a GWAS modeling, the Bayesian inference tools become necessary. Currently, another point that deserves to be highlighted in GWAS is the genetic dissection of complex phenotypes through candidate genes network derived from significant SNPs. We present a full Bayesian treatment of SNP association analysis for number of teats assuming alternatively Gaussian and Poisson distributions for this trait. Under this framework, significant SNP effects were identified by hypothesis tests using 95 % highest posterior density intervals. These SNPs were used to construct associated candidate genes network aiming to explain the genetic mechanism behind this reproductive trait. The Bayesian model comparisons based on deviance posterior distribution indicated the superiority of Gaussian model. In general, our results suggest the presence of 19 significant SNPs, which mapped 13 genes. Besides, we predicted gene interactions through networks that are consistent with the mammals known breast biology (e.g., development of prolactin receptor signaling, and cell proliferation), captured known regulation binding sites, and provided candidate genes for that trait (e.g., TINAGL1 and ICK). MenosThe genetic improvement of reproductive traits such as the number of teats is essential to the success of the pig industry. As opposite to most SNP association studies that consider continuous phenotypes under Gaussian assumptions, this trait is characterized as a discrete variable, which could potentially follow other distributions, such as the Poisson. Therefore, in order to access the complexity of a counting random regression considering all SNPs simultaneously as covariate under a GWAS modeling, the Bayesian inference tools become necessary. Currently, another point that deserves to be highlighted in GWAS is the genetic dissection of complex phenotypes through candidate genes network derived from significant SNPs. We present a full Bayesian treatment of SNP association analysis for number of teats assuming alternatively Gaussian and Poisson distributions for this trait. Under this framework, significant SNP effects were identified by hypothesis tests using 95 % highest posterior density intervals. These SNPs were used to construct associated candidate genes network aiming to explain the genetic mechanism behind this reproductive trait. The Bayesian model comparisons based on deviance posterior distribution indicated the superiority of Gaussian model. In general, our results suggest the presence of 19 significant SNPs, which mapped 13 genes. Besides, we predicted gene interactions through networks that are consistent with the mammals known breast biology (e.g., developme... Mostrar Tudo |
Palavras-Chave: |
Counting data; Inferência Bayesiana; SNP association; Teta de porco; Trato reprodutivo. |
Thesagro: |
Gene; Melhoramento Genético Animal; Suíno. |
Thesaurus NAL: |
genes; reproductive traits. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02629naa a2200325 a 4500 001 2017279 005 2016-03-02 008 2015 bl uuuu u00u1 u #d 024 7 $a10.1007/s13353-014-0240-y$2DOI 100 1 $aVERARDO, L. L. 245 $aBayesian GWAS and network analysis revealed new candidate genes for number of teats in pigs.$h[electronic resource] 260 $c2015 520 $aThe genetic improvement of reproductive traits such as the number of teats is essential to the success of the pig industry. As opposite to most SNP association studies that consider continuous phenotypes under Gaussian assumptions, this trait is characterized as a discrete variable, which could potentially follow other distributions, such as the Poisson. Therefore, in order to access the complexity of a counting random regression considering all SNPs simultaneously as covariate under a GWAS modeling, the Bayesian inference tools become necessary. Currently, another point that deserves to be highlighted in GWAS is the genetic dissection of complex phenotypes through candidate genes network derived from significant SNPs. We present a full Bayesian treatment of SNP association analysis for number of teats assuming alternatively Gaussian and Poisson distributions for this trait. Under this framework, significant SNP effects were identified by hypothesis tests using 95 % highest posterior density intervals. These SNPs were used to construct associated candidate genes network aiming to explain the genetic mechanism behind this reproductive trait. The Bayesian model comparisons based on deviance posterior distribution indicated the superiority of Gaussian model. In general, our results suggest the presence of 19 significant SNPs, which mapped 13 genes. Besides, we predicted gene interactions through networks that are consistent with the mammals known breast biology (e.g., development of prolactin receptor signaling, and cell proliferation), captured known regulation binding sites, and provided candidate genes for that trait (e.g., TINAGL1 and ICK). 650 $agenes 650 $areproductive traits 650 $aGene 650 $aMelhoramento Genético Animal 650 $aSuíno 653 $aCounting data 653 $aInferência Bayesiana 653 $aSNP association 653 $aTeta de porco 653 $aTrato reprodutivo 700 1 $aSILVA, F. F. 700 1 $aVARONA, L. 700 1 $aRESENDE, M. D. V. de 700 1 $aBASTIAANSEN, J. W. M. 700 1 $aLOPES, P. S. 700 1 $aGUIMARÃES, S. E. F. 773 $tJournal of Applied Genetics$gv. 56, n. 1, p. 123-132, Feb. 2015.
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