Data/hora: 25/06/2024 17:43:32

Biblioteca(s): 	Embrapa Pantanal.	
Data corrente: 	03/10/2001	
Data da última atualização: 	30/03/2017	
Autoria: 	DIARRA, B.; DIALL, O.; GEERTS, S.; KAGERUKA, P.; LEMMOUCHI, Y.; SCHACHT, E.; EISLER, M. C.; HOLMES, P.	
Afiliação: 	Laboratoire Central Veterinaire (Bamako, Mali); University of Ghent (Ghent, Belgica); University of Glasgow (Glasgow, Inglaterra).	
Título: 	Field evaluation of the prophylactic effect of an isometamidium sustained-release device against Trypanosomiasis in cattle.	
Ano de publicação: 	1998	
Fonte/Imprenta: 	Antimicrobial Agents and Chemotherapy, v.42, n.5, p.1012-1014, may, 1998.	
Idioma: 	Inglês	
Conteúdo: 	In order to compare the prophylactic effect provided by a poly(D,L-lactide) sustained-release device (SRD) containing isometamidium (ISMM) with that provided by the classical intramuscular injection of the drug, a field trial was carried out at the Madina Diassa Ranch in Mali. One- to 3-year-old N'Dama cattle were randomly divided into three groups. The first group (n = 42) was treated with ISMM at a dose of 1 mg/kg of body weight, the second group (n = 44) received the same dose of the drug via an SRD, which was subcutaneously implanted in the shoulder region, and the third group (n = 36) was kept as an untreated control group. All animals were treated with diminazene aceturate (7 mg/kg of body weight) 2 weeks before the start of the experiment and were tested monthly by the buffy coat technique for a period of 8 months. Glossina morsitans submorsitans was the most important tsetse species, with apparent densities (number of catches/trap/day) varying between 11.9 and 38.7 over the experimental period. Eight months after treatment the cumulative infection rates were 27.7, 58.5, and 77.4% in the group with the SRD implant, the group receiving the intramuscular injection, and the control group, respectively. Statistical analysis showed that the incidence of trypanosomiasis was significantly lower (P = 0.006) in the group which received ISMM via the SRD than in the one which was treated with ISMM intramuscularly.	
Palavras-Chave: 	Efeito profilatico; Prophylactic effect; Trypanomiasis.	
Thesagro: 	Gado.	
Thesaurus Nal: 	cattle; Trypanosoma.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Pantanal (CPAP)	
Exemplares: 	CPAP - (51734-1) - ADC - SP - PP - SP16286 -  - 16286 - DIS