| |
|
|
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
|
Data corrente: |
22/03/2013 |
|
Data da última atualização: |
13/07/2016 |
|
Autoria: |
RAGOZO, A. M. A.; YAI, L. E. O.; OLIVEIRA, L. N; DIAS, R. A.; GONÇALVES, H. C; AZEVEDO, S. S. de; DUBEY, J. P; GENNARI, S. M. |
|
Título: |
Isolation of Toxoplasma gondii from goats from Brazil. |
|
Ano de publicação: |
2009 |
|
Fonte/Imprenta: |
Journal of Parasitology, Lancaster, v. 95, n. 2, p. 323-326, 2009. |
|
Idioma: |
Inglês |
|
Conteúdo: |
Goats are economically important in many countries, and little is known of caprine toxoplasmosis in Brazil. Antibodies to Toxoplasma gondii were assayed in the sera of 143 goats from 3 Brazilian states, using modified agglutination test (MAT titer ?1:25); 46 (32.2%) tested positive. Samples of brain, heart, diaphragm, and masseter of seropositive animals were pooled, digested in pepsin, and bioassayed in mice. Viable T. gondii specimens were isolated from tissue homogenates of 12 goats; the isolates were designated TgGtBr1-12. Ten of the 12 isolates killed 100% of infected mice, indicating that goats can harbor mouse-virulent T. gondii and, hence, can serve as a source of infection for humans |
|
Palavras-Chave: |
Brasil. |
|
Thesagro: |
Caprino; Doença animal; Toxoplasma Gondii; Toxoplasmose. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 01426naa a2200265 a 4500
001 1953930
005 2016-07-13
008 2009 bl uuuu u00u1 u #d
100 1 $aRAGOZO, A. M. A.
245 $aIsolation of Toxoplasma gondii from goats from Brazil.$h[electronic resource]
260 $c2009
520 $aGoats are economically important in many countries, and little is known of caprine toxoplasmosis in Brazil. Antibodies to Toxoplasma gondii were assayed in the sera of 143 goats from 3 Brazilian states, using modified agglutination test (MAT titer ?1:25); 46 (32.2%) tested positive. Samples of brain, heart, diaphragm, and masseter of seropositive animals were pooled, digested in pepsin, and bioassayed in mice. Viable T. gondii specimens were isolated from tissue homogenates of 12 goats; the isolates were designated TgGtBr1-12. Ten of the 12 isolates killed 100% of infected mice, indicating that goats can harbor mouse-virulent T. gondii and, hence, can serve as a source of infection for humans
650 $aCaprino
650 $aDoença animal
650 $aToxoplasma Gondii
650 $aToxoplasmose
653 $aBrasil
700 1 $aYAI, L. E. O.
700 1 $aOLIVEIRA, L. N
700 1 $aDIAS, R. A.
700 1 $aGONÇALVES, H. C
700 1 $aAZEVEDO, S. S. de
700 1 $aDUBEY, J. P
700 1 $aGENNARI, S. M
773 $tJournal of Parasitology, Lancaster$gv. 95, n. 2, p. 323-326, 2009.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Ocidental. Para informações adicionais entre em contato com cpaa.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Amazônia Ocidental. |
|
Data corrente: |
02/12/2008 |
|
Data da última atualização: |
15/05/2018 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
PINTO, A. C. S.; SILVA, L. F. R. e; CAVALCANTI, B. C.; MELO, M. R. S.; CHAVES, F. C. M.; LOTUFO, L. V. C.; MORAIS, M. O. de; ANDRADE-NETO, V. F.; TADEI, W. P.; PESSOA, C. O.; VIEIRA, P. P. R.; POHLIT, A. M. |
|
Afiliação: |
Ana Cristina da Silva Pinto, UFAM; Luis Francisco Rocha e Silva, FMTAM; Bruno Coelho Cavalcanti, UFCE; Márcia Rúbia Silva Melo, INPA; FRANCISCO CELIO MAIA CHAVES, CPAA; Letícia Vera Costa Lotufo, UFCE; Manoel Odorico de Moraes, UFCE; Valter Ferreira de Andrade-Neto, Universidade Federal do Rio Grande do Norte; Wanderli Pedro Tadei, INPA; Claudia O. Pessoa, UFCE; Pedro Paulo Ribeiro Vieira, FMTAM; Adrian Martin Pohlit, INPA. |
|
Título: |
New antimalarial and cytotoxic 4-nerolidylcatechol derivatives. |
|
Ano de publicação: |
2009 |
|
Fonte/Imprenta: |
European Journal of Medicinal Chemistry, v. 44, n. 6, p. 2731-2735, June 2009. |
|
DOI: |
10.1016/j.ejmech.2008.10.025 |
|
Idioma: |
Inglês |
|
Conteúdo: |
4-nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multi-gram scale using straight-forward solvent extraction-column chromatography. New semisynthetic derivatives of 1 were prepared and tested in vitro against multidrug-resistant Plasmodium falciparum K1 strain. Mono-O-methyl, mono-O-benzyl, O,O-dibenzyl and O,Odibenzoyl derivatives 2-8 exhibited IC50 in the 0.67?22.52 ìM range. Mono-O-methyl ethers 6 and 7 inhibited the in vitro growth of human tumor cell lines HCT-8 (colon carcinoma), SF-295 (central nervous system), LH-60 (human myeloblastic leukemia) and MDA/MB-435 (melanoma). In general, derivatives 2-8 are more stable to light, air and pH at ambient temperatures than their labile, natural precursor 1. These derivatives provide leads for the development of a novel class of antimalarial drugs with enhanced chemical and pharmacological properties. |
|
Palavras-Chave: |
Plantas medicinais. |
|
Thesagro: |
Caapeba; Câncer; Química. |
|
Thesaurus NAL: |
malaria; Plasmodium falciparum. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 01861naa a2200337 a 4500
001 1683881
005 2018-05-15
008 2009 bl uuuu u00u1 u #d
024 7 $a10.1016/j.ejmech.2008.10.025$2DOI
100 1 $aPINTO, A. C. S.
245 $aNew antimalarial and cytotoxic 4-nerolidylcatechol derivatives.$h[electronic resource]
260 $c2009
520 $a4-nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a multi-gram scale using straight-forward solvent extraction-column chromatography. New semisynthetic derivatives of 1 were prepared and tested in vitro against multidrug-resistant Plasmodium falciparum K1 strain. Mono-O-methyl, mono-O-benzyl, O,O-dibenzyl and O,Odibenzoyl derivatives 2-8 exhibited IC50 in the 0.67?22.52 ìM range. Mono-O-methyl ethers 6 and 7 inhibited the in vitro growth of human tumor cell lines HCT-8 (colon carcinoma), SF-295 (central nervous system), LH-60 (human myeloblastic leukemia) and MDA/MB-435 (melanoma). In general, derivatives 2-8 are more stable to light, air and pH at ambient temperatures than their labile, natural precursor 1. These derivatives provide leads for the development of a novel class of antimalarial drugs with enhanced chemical and pharmacological properties.
650 $amalaria
650 $aPlasmodium falciparum
650 $aCaapeba
650 $aCâncer
650 $aQuímica
653 $aPlantas medicinais
700 1 $aSILVA, L. F. R. e
700 1 $aCAVALCANTI, B. C.
700 1 $aMELO, M. R. S.
700 1 $aCHAVES, F. C. M.
700 1 $aLOTUFO, L. V. C.
700 1 $aMORAIS, M. O. de
700 1 $aANDRADE-NETO, V. F.
700 1 $aTADEI, W. P.
700 1 $aPESSOA, C. O.
700 1 $aVIEIRA, P. P. R.
700 1 $aPOHLIT, A. M.
773 $tEuropean Journal of Medicinal Chemistry$gv. 44, n. 6, p. 2731-2735, June 2009.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Expressão de busca inválida. Verifique!!! |
|
|
