Data/hora: 13/06/2024 04:08:41

Biblioteca(s): | Embrapa Gado de Leite.
Data corrente: | 24/11/2014
Data da última atualização: | 05/02/2024
Autoria: | CARVALHO, W. A.; DOMINGUES, R.; PRATA, M. C. de A.; SILVA, M. V. G. B.; OLIVEIRA, G. C. de; GUIMARÃES, S. E. F.; MACHADO, M. A.
Afiliação: | WANESSA ARAUJO CARVALHO, CNPGL; ROBERT DOMINGUES, CPPSUL; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; GUILHERME CORRÊA DE OLIVEIRA, FIOCRUZ; SIMONE ELIZA FACIONI GUIMARÃES, UFV; MARCO ANTONIO MACHADO, CNPGL.
Título: | Microarray analysis of tick-infested skin in resistant and susceptible cattle confirms the role of inflammatory pathways in immune activation and larval rejection.
Ano de publicação: | 2014
Fonte/Imprenta: | Veterinary Parasitology, Amsterdam, v. 205, n. 1/2, p. 307-317, 2014.
DOI: | 10.1016/j.vetpar.2014.07.018
Idioma: | Inglês
Conteúdo: | Tick bites promote activation of an inflammatory process that is influenced by bovine genetic composition and its history of previous exposure. Taurine and indicine breeds are known to differ on its immune response development against Rhipicephalus microplus. Nevertheless, further investigation about the complex molecular pathways involved in the development of immune response to tick infestation in cattle presenting the same genetic background is mandatory. The aim of this work was to access the early immune response triggered by R. microplus larvae attachment in previously selected resistant and susceptible animals in a bovine F2 population derived from Gyr (Bos indicus)×Holstein (Bos taurus) crosses. Microarray data analysis of RNA samples from tick infested skin was used to evaluate the gene expression at 0, 24 and 48h after R. microplus larvae attachment. Our experimental design allowed us to deeply explore the immune response related to R. microplus infestation avoiding the innate differences between these breeds. The differentially expressed genes found reveal networks and pathways that suggest a key role of lipid metabolism in inflammation control and impairment of tick infestation in resistant animals. Acute phase response also seems to be impaired in susceptible animals. These results provide new insights about early immune response against ticks and raise the possibility of using immunomodulation processes to improve and develop novel tools for tick control.
Palavras-Chave: | Imunomodulação.
Thesagro: | Bovino; Imunologia.
Categoria do assunto: | L Ciência Animal e Produtos de Origem Animal
Registro original: | Embrapa Gado de Leite (CNPGL)
Exemplares: | CNPGL - (21535-1) - UPC - AP - DD -  -  -  - DIS