Data/hora: 24/09/2024 08:08:13

Biblioteca(s): 	Embrapa Agricultura Digital; Embrapa Pecuária Sudeste.	
Data corrente: 	28/07/2022	
Data da última atualização: 	31/08/2022	
Autoria: 	LIMA, A. O.; MALHEIROS, J. M.; AFONSO, J.; PETRINI, J.; COUTINHO, L. L.; DINIZ, W. J. da S.; DONATONI, F. A. B.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; RIBEIRO, J. A. S.; OLIVEIRA, K. S. de; ROCHA, M. I. P.; ANDRADE, B. G. N.; FUKUMASU, H.; BEIKI, H.; REECY, J. M.; ZERLOTINI NETO, A.; MOURAO, G. B.; REGITANO, L. C. de A.	
Afiliação: 	ANDRESSA OLIVEIRA LIMA, UFSCAR; JESSICA MORAES MALHEIROS; JULIANA AFONSO; JULIANA PETRINI, ESALQ/USP; LUIZ LEHMANN COUTINHO, ESALQ/USP; WELLISON JARLES DA SILVA DINIZ, UFSCAR; FLAVIA ALINE BRESSANI DONATONI, CPPSE; POLYANA CRISTINE TIZIOTO, NGS SOLUÇÕES GENÔMICAS, PIRACICABA; PRISCILA SILVA NEUBERN DE OLIVEIRA; JANSSEN AYNA SILVA RIBEIRO, UFSCAR; KARINA SANTOS DE OLIVEIRA, UFSCAR; MARINA IBELLI PEREIRA ROCHA, UFSCAR; BRUNO GABRIEL NASCIMENTO ANDRADE, MUNSTER TECHNOLOGICAL UNIVERSITY; HEIDGE FUKUMASU, USP; HAMID BEIKI, IOWA STATE UNIVERSITY; JAMES MARK REECY, IOWA STATE UNIVERSITY; ADHEMAR ZERLOTINI NETO, CNPTIA; GERSON BARRETO MOURAO, ESALQ/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.	
Título: 	Prune homolog 2 with BCH domain (PRUNE2) gene expression is associated with feed efficiency related traits in Nelore steers.	
Ano de publicação: 	2022	
Fonte/Imprenta: 	Mammalian Genome, 2022.	
DOI: 	https://doi.org/10.1007/s00335-022-09960-1	
Idioma: 	Inglês	
Conteúdo: 	Abstract. Animal feeding is a critical factor in increasing producer profitability. Improving feed efficiency can help reduce feeding costs and reduce the environmental impact of beef production. Candidate genes previously identified for this trait in differential gene expression studies (e.g., case?control studies) have not examined continuous gene-phenotype variation, which is a limitation. The aim of this study was to investigate the association between the expression of five candidate genes in the liver, measured by quantitative real-time PCR and feed-related traits. We adopted a linear mixed model to associate liver gene expression from 52 Nelore steers with the following production traits: average daily gain (ADG), body weight (BW), dry matter intake (DMI), feed conversion ratio (FCR), feed efficiency (FE), Kleiber index (KI), metabolic body weight (MBW), residual feed intake (RFI), and relative growth ratio (RGR). The total expression of the prune homolog 2 (PRUNE2) gene was significantly associated with DMI, FCR, FE, and RFI (P < 0.05). Furthermore, we have identified a new transcript of PRUNE2 (TCONS_00027692, GenBank MZ041267) that was inversely correlated with FCR and FE (P < 0.05), in contrast to the originally identified PRUNE2 transcript. The cytochrome P450 subfamily 2B (CYP2B6), early growth response protein 1 (EGR1), collagen type I alpha 1 chain (COL1A1), and connective tissue growth factor (CTGF) genes were not associated with any feed efficiency-related traits (P > 0.05). The findings reported herein suggest that PRUNE2 expression levels affects feed efficiency-related traits variation in Nelore steers.	
Palavras-Chave: 	Apoptose; Características relacionadas à alimentação; Expressão gênica no fígado de Nelore; Reação em cadeia da polimerase; Reação em cadeia da polimerase em tempo real; Real-time quantitative PCR.	
Thesagro: 	Fígado; Gado de Corte; Gado Nelore.	
Thesaurus Nal: 	Apoptosis; Beef cattle; Gene expression; Liver; Polymerase chain reaction.	
Categoria do assunto: 	--
G Melhoramento Genético	
Registro original: 	Embrapa Pecuária Sudeste (CPPSE)	
Exemplares: 	CNPTIA - (21231-1) - UPC - AP - DD -  -  -  - DIS
CPPSE - (25685-1) - UPC - AP - DD - PROCI-2022.00048 - LIM - 2022.00103 - DIS