Data/hora: 16/06/2024 04:49:14

Biblioteca(s): | Embrapa Unidades Centrais.
Data corrente: | 01/04/2016
Data da última atualização: | 29/12/2017
Autoria: | ANDRADE, D. G. A.; DALANEZI, F. M.; TRECENTI, A. S.; CUNHA, P. H. J.; BORGES, A. S.; OLIVEIRA-FILHO, J. P.
Afiliação: | DANILO G. A. ANDRADE, UNESP; FELIPE M. DALANEZI, UNESP; ANELIZE S. TRECENTI, UNESP; PAULO HENRIQUE J. CUNHA, UFG; ALEXANDRE S. BORGES, UNESP; JOSÉ P. OLIVEIRA-FILHO, UNESP.
Título: | Prevalence study of SNP c.421G>T in the ADAMTS2 gene responsible for dermtosparaxis in white doper sheep in Brazil.
Ano de publicação: | 2016
Fonte/Imprenta: | Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 2, p. 73-76, fev. 2016.
Idioma: | Inglês
Conteúdo: | Dermatosparaxis is an autosomal recessive disorder of connective tissue; the disorder is clinically characterized by skin fragility and hyperextensibility. Dermatosparaxis in White Dorper sheep is caused by a single nucleotide polymorphism (SNP) (c.421G>T) in the ADAM metalloproteinase with thrombospondin type 1 motif, 2 (ADAMTS2) gene. The aim of this study was to investigate the prevalence of this SNP in a White Dorper herd in São Paulo state, Brazil. In this study, we collected blood DNA samples from 303 White Dorper sheep and performed polymerase chain reaction to amplify the SNP region. The samples were sequenced to determine the presence of the SNP in the ADAMTS2 gene. The SNP prevalence in the studied population was 15.5%; this finding indicates that more effective control measures should be used to prevent the inheritance of SNP c.421G>T in the ADAMTS2 gene in Brazilian White Dorper herds.
Palavras-Chave: | Astênia cutânea; Autossômica recessiva; Cutaneous asthenia; White dorper.
Thesagro: | Ovino.
Thesaurus Nal: | Sheep.
Categoria do assunto: | --
URL: | http://ainfo.cnptia.embrapa.br/digital/bitstream/item/141915/1/Prevalence-study-of-SNP.pdf
Registro original: | Embrapa Unidades Centrais (AI-SEDE)
Exemplares: | AI-SEDE - (59261-1) - UPE - AP - PP - 636.08905 - P474 -  - DIS