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![](/consulta/web/img/deny.png) | Acesso ao texto completo restrito à biblioteca da Embrapa Clima Temperado. Para informações adicionais entre em contato com cpact.biblioteca@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Clima Temperado. |
Data corrente: |
27/12/2023 |
Data da última atualização: |
27/12/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
MELLO, J. E. DE; LUDUVICO, K. P.; SANTOS, A. DOS; TEIXEIRA, F. C.; CARDOSO, J. DE S.; AGUIAR, M. S. S. DE; CUNICO, W.; VIZZOTTO, M.; STEFANELLO, F.; SPANEVELLO, R. |
Afiliação: |
JULIA EISENHARDT DE MELLO, UNIVERSIDADE FEDERAL DE PELOTAS; KARINA PEREIRA LUDUVICO, UNIVERSIDADE FEDERAL DE PELOTAS; ALESSANDRA DOS SANTOS, UNIVERSIDADE FEDERAL DE PELOTAS; FERNANDA CARDOSO TEIXEIRA, UNIVERSIDADE FEDERAL DE PELOTAS; JULIANE DE SOUZA CARDOSO, UNIVERSIDADE FEDERAL DE PELOTAS; MAYARA SANDRIELLY SOARES DE AGUIAR, UNIVERSIDADE FEDERAL DE PELOTAS; WILSON CUNICO, UNIVERSIDADE FEDERAL DE PELOTAS; MARCIA VIZZOTTO FOSTER, CPACT; FRANCIELI STEFANELLO, UNIVERSIDADE FEDERAL DE PELOTAS; ROSELIA SPANEVELLO, UNIVERSIDADE FEDERAL DE PELOTAS. |
Título: |
Therapeutic potential of blackberry extract in the preventing memory defcits and neurochemical alterations in the cerebral cortex, hippocampus and cerebellum of a rat model with amnesia. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
Metabolic Brain Disease, v. 38, p. 1261–1272, 2023. |
DOI: |
https://doi.org/10.1007/s11011-023-01175-w |
Idioma: |
Inglês |
Conteúdo: |
The blackberry (Rubus sp.) is a popular fruit that has a high concentration of phenolic compounds. Pharmacological investigations have demonstrated the important biological activities of the blackberry extract, such as neuroprotective actions. This study aimed to evaluate the efects of blackberry extract on memory and neurochemical parameters in rats subjected to scopolamine (SCO)-induced amnesia. Male rats were divided into fve groups: I, control (saline); II, SCO; III, SCO +Rubus sp. (100 mg/kg); IV, SCO+Rubus sp. (200 mg/kg); and V, SCO+donepezil (5 mg/kg). Blackberry extract and donepezil were orally administered for 10 days. On day 11, group I received saline, and groups II, III, IV, and V received SCO (1 mg/kg) intraperitoneally after object recognition behavioral training. Twenty-four hours after the training session, animals were subjected to an object recognition test. Finally, the animals were euthanized, and the cerebral cortex, hippocampus, and cerebellum were collected to evaluate the oxidative stress and acetylcholinesterase (AChE) activity. Rubus sp. extract prevented memory impairment induced by SCO in a manner similar to that of donepezil. Additionally, Rubus sp. extract and donepezil prevented the increase in AChE activity induced by SCO in all the evaluated brain structures. SCO induced oxidative damage in the cerebral cortex, hippocampus, and cerebellum, which was prevented by Rubus sp. and donepezil. Our results suggest that the antioxidant and anticholinesterase activities of Rubus sp. are associated with memory improvement; hence, it can potentially be used for the treatment of neurodegenerative diseases. MenosThe blackberry (Rubus sp.) is a popular fruit that has a high concentration of phenolic compounds. Pharmacological investigations have demonstrated the important biological activities of the blackberry extract, such as neuroprotective actions. This study aimed to evaluate the efects of blackberry extract on memory and neurochemical parameters in rats subjected to scopolamine (SCO)-induced amnesia. Male rats were divided into fve groups: I, control (saline); II, SCO; III, SCO +Rubus sp. (100 mg/kg); IV, SCO+Rubus sp. (200 mg/kg); and V, SCO+donepezil (5 mg/kg). Blackberry extract and donepezil were orally administered for 10 days. On day 11, group I received saline, and groups II, III, IV, and V received SCO (1 mg/kg) intraperitoneally after object recognition behavioral training. Twenty-four hours after the training session, animals were subjected to an object recognition test. Finally, the animals were euthanized, and the cerebral cortex, hippocampus, and cerebellum were collected to evaluate the oxidative stress and acetylcholinesterase (AChE) activity. Rubus sp. extract prevented memory impairment induced by SCO in a manner similar to that of donepezil. Additionally, Rubus sp. extract and donepezil prevented the increase in AChE activity induced by SCO in all the evaluated brain structures. SCO induced oxidative damage in the cerebral cortex, hippocampus, and cerebellum, which was prevented by Rubus sp. and donepezil. Our results suggest that the antioxidant and anticholi... Mostrar Tudo |
Thesagro: |
Amora; Amora Preta; Extrato; Extrato de Fruta. |
Thesaurus Nal: |
Rubus. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02619naa a2200301 a 4500 001 2160274 005 2023-12-27 008 2023 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1007/s11011-023-01175-w$2DOI 100 1 $aMELLO, J. E. DE 245 $aTherapeutic potential of blackberry extract in the preventing memory defcits and neurochemical alterations in the cerebral cortex, hippocampus and cerebellum of a rat model with amnesia.$h[electronic resource] 260 $c2023 520 $aThe blackberry (Rubus sp.) is a popular fruit that has a high concentration of phenolic compounds. Pharmacological investigations have demonstrated the important biological activities of the blackberry extract, such as neuroprotective actions. This study aimed to evaluate the efects of blackberry extract on memory and neurochemical parameters in rats subjected to scopolamine (SCO)-induced amnesia. Male rats were divided into fve groups: I, control (saline); II, SCO; III, SCO +Rubus sp. (100 mg/kg); IV, SCO+Rubus sp. (200 mg/kg); and V, SCO+donepezil (5 mg/kg). Blackberry extract and donepezil were orally administered for 10 days. On day 11, group I received saline, and groups II, III, IV, and V received SCO (1 mg/kg) intraperitoneally after object recognition behavioral training. Twenty-four hours after the training session, animals were subjected to an object recognition test. Finally, the animals were euthanized, and the cerebral cortex, hippocampus, and cerebellum were collected to evaluate the oxidative stress and acetylcholinesterase (AChE) activity. Rubus sp. extract prevented memory impairment induced by SCO in a manner similar to that of donepezil. Additionally, Rubus sp. extract and donepezil prevented the increase in AChE activity induced by SCO in all the evaluated brain structures. SCO induced oxidative damage in the cerebral cortex, hippocampus, and cerebellum, which was prevented by Rubus sp. and donepezil. Our results suggest that the antioxidant and anticholinesterase activities of Rubus sp. are associated with memory improvement; hence, it can potentially be used for the treatment of neurodegenerative diseases. 650 $aRubus 650 $aAmora 650 $aAmora Preta 650 $aExtrato 650 $aExtrato de Fruta 700 1 $aLUDUVICO, K. P. 700 1 $aSANTOS, A. DOS 700 1 $aTEIXEIRA, F. C. 700 1 $aCARDOSO, J. DE S. 700 1 $aAGUIAR, M. S. S. DE 700 1 $aCUNICO, W. 700 1 $aVIZZOTTO, M. 700 1 $aSTEFANELLO, F. 700 1 $aSPANEVELLO, R. 773 $tMetabolic Brain Disease$gv. 38, p. 1261–1272, 2023.
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Embrapa Clima Temperado (CPACT) |
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Biblioteca(s): |
Embrapa Trigo. |
Data corrente: |
03/11/2010 |
Data da última atualização: |
09/07/2019 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
CARVALHO, P. C. de F.; ANGHINONI, I.; MORAES, A. de; SOUZA, E. D. de; SULC, R. M.; LANG, C. R.; FLORES, J. P. C.; LOPES, M. L. T.; SILVA, J. L. S. da; CONTE, O.; WESP. C. DE L.; LEVIEN, R.; FONTANELI, R. S.; BAYER, C. |
Afiliação: |
PAULO CÉSAR DE FACCIO CARVALHO, UFRGS; IBANOR ANGHINONI, UFRGS; ANIBAL DE MORAES, UFPR; EDICARLOS DAMACENA DE SOUZA, UFGO; REUBEN MARK SULC, OHIO STATE UNIVERSITY; CLAUDETE REISDORFER LANG, UFPR; JOÃO PAULO CASSOL FLORES, VIRGINIA POLYTECHNIC INSTITUTE & STATE UNIVERSITY; MARÍLIA LAZZAROTTO TERRA LOPES, UFRGS; JAMIR LUIS SILVA DA SILVA, CPACT; OSMAR CONTE, UFRGS; CRISTIANE DE LIMA WESP, UFRGS; RENATO LEVIEN, UFRGS; RENATO SERENA FONTANELI, CNPT; CIMELIO BAYER, UFRGS. |
Título: |
Managing grazing animals to achieve nutrient cycling and soil improvement in no-till integrated systems. |
Ano de publicação: |
2010 |
Fonte/Imprenta: |
Nutrient Cycling in Agroecosystem, v. 88, n. 2, p. 259-273, Nov. 2010. |
ISSN: |
1385-1314 (Print) 1573-0867 (Online) |
DOI: |
10.1007/s10705-010-9360-x |
Idioma: |
Inglês |
Conteúdo: |
Crop-livestock systems are regaining their importance as an alternative to unsustainable intensive farming systems. Loss of biodiversity, nutrient pollution and habitat fragmentation are a few of many concerns recently reported with modern agriculture. Integrating crops and pastures in no-till systems can result in better environmental services, since conservation agriculture is improved by system diversity, paths of nutrient flux, and other processes common in nature. The presence of large herbivores can positively modify nutrient pathways and soil aggregation, increasing soil quality. Despite the low diversity involved, the integration of crops and pastures enhances nature?s biomimicry and allows attainment of a higher system organization level. This paper illustrates these benefits focusing on the use of grazing animals integrated with crops under no-tillage systems characteristic of southern Brazil. |
Palavras-Chave: |
Alimentação animal; ILP. |
Thesagro: |
Pastagem; Plantio Direto. |
Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
URL: |
https://link.springer.com/content/pdf/10.1007%2Fs10705-010-9360-x.pdf
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Marc: |
LEADER 01949naa a2200349 a 4500 001 1865937 005 2019-07-09 008 2010 bl --- 0-- u #d 022 $a1385-1314 (Print) 1573-0867 (Online) 024 7 $a10.1007/s10705-010-9360-x$2DOI 100 1 $aCARVALHO, P. C. de F. 245 $aManaging grazing animals to achieve nutrient cycling and soil improvement in no-till integrated systems.$h[electronic resource] 260 $c2010 520 $aCrop-livestock systems are regaining their importance as an alternative to unsustainable intensive farming systems. Loss of biodiversity, nutrient pollution and habitat fragmentation are a few of many concerns recently reported with modern agriculture. Integrating crops and pastures in no-till systems can result in better environmental services, since conservation agriculture is improved by system diversity, paths of nutrient flux, and other processes common in nature. The presence of large herbivores can positively modify nutrient pathways and soil aggregation, increasing soil quality. Despite the low diversity involved, the integration of crops and pastures enhances nature?s biomimicry and allows attainment of a higher system organization level. This paper illustrates these benefits focusing on the use of grazing animals integrated with crops under no-tillage systems characteristic of southern Brazil. 650 $aPastagem 650 $aPlantio Direto 653 $aAlimentação animal 653 $aILP 700 1 $aANGHINONI, I. 700 1 $aMORAES, A. de 700 1 $aSOUZA, E. D. de 700 1 $aSULC, R. M. 700 1 $aLANG, C. R. 700 1 $aFLORES, J. P. C. 700 1 $aLOPES, M. L. T. 700 1 $aSILVA, J. L. S. da 700 1 $aCONTE, O. 700 1 $aWESP. C. DE L. 700 1 $aLEVIEN, R. 700 1 $aFONTANELI, R. S. 700 1 $aBAYER, C. 773 $tNutrient Cycling in Agroecosystem$gv. 88, n. 2, p. 259-273, Nov. 2010.
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