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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Alimentos e Territórios. |
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Data corrente: |
17/11/2023 |
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Data da última atualização: |
17/11/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PINHEIRO, J. C. A.; SOUZA, C. E. S. DE; RIBEIRO, D. A.; SILVA, A. DE A.; SILVA, V. B. DA; SANTOS, A. T. L. DOS; FONSECA, V. J. A.; MACÊDO, D. G. DE; CRUZ, R. P. DA; BEZERRA, J. W. A.; MACHADO, A. J. T.; FREITAS, T. S. DE; BRITO, E. S. de; RIBEIRO, P. R. V.; COSTA, J. G. M. DA; COUTINHO, H. D. M.; KOWALSKA, G.; ROWINSKI, R.; KOWALSKI, R.; BRAGA, M. F. B. M. |
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Afiliação: |
JACQUELINE COSMO ANDRADE-PINHEIRO, Regional University of Cariri; CELESTINA ELBA SOBRAL DE SOUZA, Regional University of Cariri; DAIANY ALVES RIBEIRO, Regional University of Cariri; ANDRESSA DE ALENCAR SILVA, Regional University of Cariri; VIVIANE BEZERRA DA SILVA, Federal University of Pernambuco; ANTONIA THASSYA LUCAS DOS SANTOS, Regional University of Cariri; VICTOR JUNO ALENCAR FONSECA, Regional University of Cariri; DELMACIA GONÇALVES DE MACÊDO, Regional University of Cariri; RAFAEL PEREIRA DA CRUZ, Regional University of Cariri; JOSÉ WEVERTON ALMEIDA-BEZERRA, Regional University of Cariri; ANTONIO JÚDSON TARGINO MACHADO, Regional University of Cariri; THIAGO SAMPAIO DE FREITAS, Regional University of Cariri; EDY SOUSA DE BRITO, CNAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; JOSÉ GALBERTO MARTINS DA COSTA, Regional University of Cariri; HENRIQUE DOUGLAS MELO COUTINHO, Regional University of Cariri; GRAZYNA KOWALSKA, University of Life Sciences in Lublin; RAFAL ROWINSKI, University of Life Sciences in Lublin; RADOSLAW KOWALSKI, University of Life Sciences in Lublin; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, Regional University of Cariri. |
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Título: |
LC-MS analysis and antifungal activity of Turnera subulata Sm. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Plants, v. 12, n. 415, 2023. |
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Páginas: |
12 p. |
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DOI: |
10.3390/plants12020415 |
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Idioma: |
Inglês |
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Conteúdo: |
Fungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it difficult to treat these infections. In this way, natural products have emerged as an alternative to standard drugs, where plants known for their medicinal properties such as Turnera subulata become attractive to research. The present work aimed to analyze the ethanol extract of Turnera subulata leaves against standard strains of Candida albicans, Candida krusei and Candida tropicalis using broth microdilution techniques. The identification of the compounds in T. subulata leaves by LC-MS revealed the presence of a wide variety of substances such as carboxylic acids and terpenes, with flavonoids and fatty acids being more evident. The antifungal assays showed that the extract was not able to inhibit the growth of the tested strains at concentrations with a clinical relevance. However, at higher concentrations, it was able to inhibit the fungal dimorphism of C. albicans and C. tropicalis. It is possible that the T. subulata extract has potential as an inhibitor of fungal virulence factors without affecting the cell viability. Further research should be carried out in order to assess its inhibitory potential for other fungal virulence factors. |
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Palavras-Chave: |
Antifungal; Antifúngico; Extract; Extrair; Levedura; Virulência. |
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Thesaurus Nal: |
Antifungal agents; Extracts; Virulence; Yeasts. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1158504/1/LC-MS-Analysis.pdf
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Marc: |
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001 2158504
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024 7 $a10.3390/plants12020415$2DOI
100 1 $aPINHEIRO, J. C. A.
245 $aLC-MS analysis and antifungal activity of Turnera subulata Sm.$h[electronic resource]
260 $c2023
300 $a12 p.
520 $aFungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it difficult to treat these infections. In this way, natural products have emerged as an alternative to standard drugs, where plants known for their medicinal properties such as Turnera subulata become attractive to research. The present work aimed to analyze the ethanol extract of Turnera subulata leaves against standard strains of Candida albicans, Candida krusei and Candida tropicalis using broth microdilution techniques. The identification of the compounds in T. subulata leaves by LC-MS revealed the presence of a wide variety of substances such as carboxylic acids and terpenes, with flavonoids and fatty acids being more evident. The antifungal assays showed that the extract was not able to inhibit the growth of the tested strains at concentrations with a clinical relevance. However, at higher concentrations, it was able to inhibit the fungal dimorphism of C. albicans and C. tropicalis. It is possible that the T. subulata extract has potential as an inhibitor of fungal virulence factors without affecting the cell viability. Further research should be carried out in order to assess its inhibitory potential for other fungal virulence factors.
650 $aAntifungal agents
650 $aExtracts
650 $aVirulence
650 $aYeasts
653 $aAntifungal
653 $aAntifúngico
653 $aExtract
653 $aExtrair
653 $aLevedura
653 $aVirulência
700 1 $aSOUZA, C. E. S. DE
700 1 $aRIBEIRO, D. A.
700 1 $aSILVA, A. DE A.
700 1 $aSILVA, V. B. DA
700 1 $aSANTOS, A. T. L. DOS
700 1 $aFONSECA, V. J. A.
700 1 $aMACÊDO, D. G. DE
700 1 $aCRUZ, R. P. DA
700 1 $aBEZERRA, J. W. A.
700 1 $aMACHADO, A. J. T.
700 1 $aFREITAS, T. S. DE
700 1 $aBRITO, E. S. de
700 1 $aRIBEIRO, P. R. V.
700 1 $aCOSTA, J. G. M. DA
700 1 $aCOUTINHO, H. D. M.
700 1 $aKOWALSKA, G.
700 1 $aROWINSKI, R.
700 1 $aKOWALSKI, R.
700 1 $aBRAGA, M. F. B. M.
773 $tPlants$gv. 12, n. 415, 2023.
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Registro original: |
Embrapa Alimentos e Territórios (CNAT) |
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| Registros recuperados : 70 | |
| 1. |  | SMYTH, T. J. Adubação do guaranazeiro. Manaus: EMBRAPA-UEPAE de Manaus, 1982. 16 p. Trabalho apresentado no Curso de Atualização em Fertilidade de Solos Tropicais, Manaus, 1982.| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 11. | | SMYTH, T. J.; BASTOS, J. B. Adubação potássica para milho e caupi em latossolo amarelo alico do Estado do Amazonas. In: SIMPÓSIO DO TRÓPICO ÚMIDO, 1., 1984, Belém, PA. Anais. Belém, PA: EMBRAPA-CPATU, 1986. v. 3, p. 173-181. (EMBRAPA-CPATU. Documentos, 36).| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Ocidental; Embrapa Amazônia Oriental. |
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| Registros recuperados : 70 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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