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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Instrumentação. |
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Data corrente: |
28/09/2018 |
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Data da última atualização: |
15/01/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SCHNEIDER, R.; MERCANTE, L. A.; ANDRE, R. S.; BRANDÃO, H. M.; MATTOSO, L. H. C.; CORREA, D. S. |
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Afiliação: |
LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA; DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Biocompatible electrospun nanofibers containing cloxacillin: Antibacterial activity and effect of PH on the release profile. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Reactive and Functional Polymers, n. 132, p. 26-35, nov. 2018. |
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ISSN: |
1381-5148 |
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DOI: |
10.1016/j.reactfunctpolym.2018.09.001 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract The effectiveness of antibiotics toward resistant strains of bacteria has brought serious concerns related to human and animal health. Controlled drug release systems, especially those based on polymer and polymer-based nanostructures appears as a remarkable approach, once they can potentially improve the therapeutic outcomes toward bacterial infections, while requiring lower amounts of drugs. The current study was designed to investigate the incorporation and release profile of a drug loaded in biodegradable electrospun nanofibrous membranes, based on the drug-polymer interactions, as well as its ability to inhibit bacterial growth. For that purpose, nanofibrous membranes of Ecovio® (EC), a polymer blend composed by poly (lactic acid) (PLA)/poly (butylene adipate-co-terephthalate) (PBAT), loaded with different cloxacillin (CLOX) contents were successfully produced via electrospinning technique. Electrospun nanofibers of EC unloaded and loaded with drug presented smooth surface with a mean diameter close to 600 nm. The physical-chemical characterizations by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the successful drug encapsulation achieved by electrospinning technique. In vitro studies revealed that the developed drug-loaded nanofibrous membrane was successful in inhibiting S. aureus growth. The cumulative release of drug from EC nanofibrous membranes containing 20% of CLOX was demonstrated to be pH dependent, where the antibiotic release rate was much faster for pH 7.3 than that for pH 5.5. In this way, the mechanism involved in the release could be either Fickian or non-Fickian depending on the pH environment. The simple and efficient strategy presented here to develop antimicrobial nanofibrous membrane make them promising for drug delivery carrier and wound dressing applications. MenosAbstract The effectiveness of antibiotics toward resistant strains of bacteria has brought serious concerns related to human and animal health. Controlled drug release systems, especially those based on polymer and polymer-based nanostructures appears as a remarkable approach, once they can potentially improve the therapeutic outcomes toward bacterial infections, while requiring lower amounts of drugs. The current study was designed to investigate the incorporation and release profile of a drug loaded in biodegradable electrospun nanofibrous membranes, based on the drug-polymer interactions, as well as its ability to inhibit bacterial growth. For that purpose, nanofibrous membranes of Ecovio® (EC), a polymer blend composed by poly (lactic acid) (PLA)/poly (butylene adipate-co-terephthalate) (PBAT), loaded with different cloxacillin (CLOX) contents were successfully produced via electrospinning technique. Electrospun nanofibers of EC unloaded and loaded with drug presented smooth surface with a mean diameter close to 600 nm. The physical-chemical characterizations by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the successful drug encapsulation achieved by electrospinning technique. In vitro studies revealed that the developed drug-loaded nanofibrous membrane was successful in inhibiting S. aureus growth. The cumulative release of drug from EC nanofibrous membranes containing 20% o... Mostrar Tudo |
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Palavras-Chave: |
Drug delivery; Electrospinning; Modulated release. |
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Categoria do assunto: |
--
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02706naa a2200241 a 4500
001 2096544
005 2019-01-15
008 2018 bl uuuu u00u1 u #d
022 $a1381-5148
024 7 $a10.1016/j.reactfunctpolym.2018.09.001$2DOI
100 1 $aSCHNEIDER, R.
245 $aBiocompatible electrospun nanofibers containing cloxacillin$bAntibacterial activity and effect of PH on the release profile.$h[electronic resource]
260 $c2018
520 $aAbstract The effectiveness of antibiotics toward resistant strains of bacteria has brought serious concerns related to human and animal health. Controlled drug release systems, especially those based on polymer and polymer-based nanostructures appears as a remarkable approach, once they can potentially improve the therapeutic outcomes toward bacterial infections, while requiring lower amounts of drugs. The current study was designed to investigate the incorporation and release profile of a drug loaded in biodegradable electrospun nanofibrous membranes, based on the drug-polymer interactions, as well as its ability to inhibit bacterial growth. For that purpose, nanofibrous membranes of Ecovio® (EC), a polymer blend composed by poly (lactic acid) (PLA)/poly (butylene adipate-co-terephthalate) (PBAT), loaded with different cloxacillin (CLOX) contents were successfully produced via electrospinning technique. Electrospun nanofibers of EC unloaded and loaded with drug presented smooth surface with a mean diameter close to 600 nm. The physical-chemical characterizations by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the successful drug encapsulation achieved by electrospinning technique. In vitro studies revealed that the developed drug-loaded nanofibrous membrane was successful in inhibiting S. aureus growth. The cumulative release of drug from EC nanofibrous membranes containing 20% of CLOX was demonstrated to be pH dependent, where the antibiotic release rate was much faster for pH 7.3 than that for pH 5.5. In this way, the mechanism involved in the release could be either Fickian or non-Fickian depending on the pH environment. The simple and efficient strategy presented here to develop antimicrobial nanofibrous membrane make them promising for drug delivery carrier and wound dressing applications.
653 $aDrug delivery
653 $aElectrospinning
653 $aModulated release
700 1 $aMERCANTE, L. A.
700 1 $aANDRE, R. S.
700 1 $aBRANDÃO, H. M.
700 1 $aMATTOSO, L. H. C.
700 1 $aCORREA, D. S.
773 $tReactive and Functional Polymers$gn. 132, p. 26-35, nov. 2018.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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| Registros recuperados : 349 | |
| 161. |  | De BONI, L. FONSECA, R. D. CARDOSO, K. R. A. GROVA, I. AKCELRUD, L.; CORREA, D. S.; MENDONÇA, C. R. Characterization of two- and three-photon absorption of polyfluorene derivates. Journal of Polymer Science: part B: Polymer Physics, New York, v. 52, p. 747-754, 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 162. | | CEZARO, A. M.; RIGO, A. A.; MARTINAZZO, J.; MUENCHEN, D. K.; MANZOLI, A.; CORREA, D. S.; STEFFENS, J.; STEFFENS, C. Cantilever nanobiosensor functionalized with tyrosinase for detection of estrone and B-estradiol in water. Applied Biochemistry and Biotechnology, v. 190, 2020. 1512 -1524| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 164. | | CARMO, M. S.; MARTINS, T.; SCAGION V. P.; ALLERDING, L.; OLIVEIRA, J. E.; MATTOSO, L. H. C.; CORREA, D. S. Caracterização e desempenho de uma língua eletrônica utilizando eletrodos interdigitados de baixo custo. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 7.; ESCOLA DE NANOTECNOLOGIA, 3., 2013, São Carlos, SP. Anais... São Carlos, SP: Embrapa Instrumentação, 2013. p. 25-26 Editores: Maria Alice Martins, Odílio Benedito Garrido de Assis, Caue Ribeiro, Luiz Henrique Capparelli Mattoso. CD-ROM. Editores: Maria Alice Martins, Odílio Benedito Garrido de Assis, Caue Ribeiro, Luiz Henrique Capparelli Mattoso.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 168. | | MANZOLI, A.; CORREA, A. A.; MERCANTE, L. A.; PARIS, E. C.; CORREA, D. S.; MATTOSO, L. H. C. Investigação por FEG-MEV da estrutura de nanocompósitos do tipo CORE-SHELL de prata-polianilina. In: CONGRESSO BRASILEIRO DE POLÍMEROS, 12., 2013, Florianópolis. Anais... São Carlos: ABPol, 2013.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 170. | | BILATTO, S. E. R.; COSTA, M. A.; HOFFMEISTER, C. R. D.; ROCHA, H.; MATTOSO, L. H. C.; CORREA, D. S. Língua eletrônica baseada em polímeros condutores para análise de fármacos: modificações na formulação do EFA VIRENZ. In: CONGRESSO BRASILEIRO DE POLÍMEROS, 12., 2013, Florianópolis. Anais... São Carlos: ABPol, 2013.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 171. | | ANDRE, R. S.; PAVINATTO, A.; MERCANTE, L. A.; PARIS, E. C.; MATTOSO, L. H. C.; CORREA, D. S. Improving the electrochemical properties of polyamide 6/polyaniline electrospun nanofibers by surface modification with ZnO nanoparticles. RSC advances, [Inglaterra], v. 5, n. 90, p. 73875-73881, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 172. | | SCHNEIDER, R.; MERCANTE, L. A.; ANDRE, R. S.; CHRISTINELLI, W. A.; TERRA, I. A. A.; CORREA, D. S. Immobilization of exfoliated dichalcogenide in nanofibers: investigation of morphology and optical properties. In: BRAZIL MRS MEETING - SBPMAT, 17, 2018, Natal, RN. Proceedings... Natal, RN: SBPMat, 2018.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 173. | | MERCANTE, L. A.; ANDRE, R. S.; PEREIRA, J.; LOCILENTO, D.; MATTOSO, L. H. C.; CORREA, D. S. Humidity sensing properties of ZnO-Co3O4 nanofibers decorated with a polyelectrolyte. In: BRAZIL MRS MEETING - SBPMAT, 17, 2018, Natal, RN. Proceedings... Natal, RN: SBPMat, 2018.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 179. | | SCAGION, V. P.; OLIVEIRA, J. E.; BONI, L. de; MENDONÇA, C. R.; MATTOSO, L. H. C.; CORREA, D. S. Estudo da morfologia de fibras de poli(metacrilato de metila) obtidas pela técnica de eletrofiação. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 6., 2012, Fortaleza. Anais... São Carlos: Embrapa Instrumentação; Fortaleza: Embrapa Agroindústria Tropical, 2012. p. 27-29. Editores: Maria Alice Martins, MOrsyleide de Freitas Rosa, Men de Sá Moreira de Souza Filho, Nicodemos Moreira dos Santos Junior, Odílio Benedito Garrido de Assis, Caue Ribeiro, Luiz Henrique Capparelli Mattoso.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 180. | | MIRANDA, M.; YAMANE, E. Y.; SANTOS, K. A. F. dos; PILON, L.; CORREA, D. S.; FERREIRA, M. D. Estudo preliminar da aplicação pós-colheita de nanoemulsão de cera vegetal em tomates "Pizzadouro". In: CONGRESSO BRASILEIRO DE PROCESSAMENTO MÍNIMO E PÓS COLHEITA DE FRUTAS, FLORES E HORTALIÇAS, 1.; SIMPÓSIO BRASILEIRO DE PÓS-COLHEITA, FRUTAS, HORTALIÇAS E FLORES, 5.; ENCONTRO NACIONAL SOBRE PROCESSAMENTO MÍNIMO DE FRUTAS E HORTALIÇAS, 8., 2015, Aracaju, SE. Anais... Aracaju, SE: CBPMPC, 2015. Não paginado. 8 f.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| Registros recuperados : 349 | |
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