| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Gado de Leite. |
|
Data corrente: |
19/11/2013 |
|
Data da última atualização: |
05/02/2024 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
UTSUNOMIYA, Y. T.; CARMO, A. S. do; CARVALHEIRO, R.; NEVES, H. H. R.; MATOS, M. C.; ZAVAREZ, L. B.; O'BRIEN, A. M. P.; SÖLKNER, J.; McEWAN, J. C.; COLE, J. B.; TASSEL, C. P. V.; SCHENKEL, F. S.; SILVA, M. V. G. B.; PORTO NETO, L. R.; SONSTEGARD, T. S.; GARCIA, J. F. |
|
Afiliação: |
YURI T. UTSUNOMIYA, UNESP; ADRIANA S. DO CARMO, UNESP; ROBERTO CARVALHEIRO, GenSys Consultores Associados; HAROLDO H. R. NEVES, UNESP; MÁRCIA C. MATOS, UNESP; LUDMILLA B. ZAVAREZ, UNESP; ANA M. PÉREZ O'BRIEN, University of Natural Resources and Life Sciences, Vienna; JOHANN SÖLKNER, University of Natural Resources and Life Sciences, Vienna; JOHN C. McEWAN, Centre for Reproduction and Genomics, AgResearch, Mosgiel, New Zealand; JOHN B. COLE, ARS-USDA, USA; CURTIS P. VAN TASSEL, ARS-USDA, USA; FLÁVIO S. SCHENKEL, University of Guelph, Canada; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; LAERCIO R. PORTO NETO, University of Queensland, Australia; University of New England, Australia; TAD S. SONSTEGARD, ARS-USDA, USA; JOSÉ F. GARCIA, UNESP. |
|
Título: |
Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height. |
|
Ano de publicação: |
2013 |
|
Fonte/Imprenta: |
BMC Genetics, London, v. 14, article 52, 2013. |
|
DOI: |
https://doi.org/10.1186/1471-2156-14-52 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Background - Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs). Results - The most significant SNP (rs133012258, PGC = 1.34 × 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length. Conclusions- This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with body size in taurine cattle (Bos primigenius taurus) also affect birth weight and size in zebu cattle (Bos primigenius indicus). MenosBackground - Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs). Results - The most significant SNP (rs133012258, PGC = 1.34 × 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length. Conclusions- This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with ... Mostrar Tudo |
|
Palavras-Chave: |
Bos primigenius indicus; GWAS; Nellore cattle; Stature. |
|
Thesaurus Nal: |
birth weight. |
|
Categoria do assunto: |
G Melhoramento Genético |
|
Marc: |
LEADER 02754naa a2200373 a 4500
001 1971572
005 2024-02-05
008 2013 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/1471-2156-14-52$2DOI
100 1 $aUTSUNOMIYA, Y. T.
245 $aGenome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height.$h[electronic resource]
260 $c2013
520 $aBackground - Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs). Results - The most significant SNP (rs133012258, PGC = 1.34 × 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length. Conclusions- This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with body size in taurine cattle (Bos primigenius taurus) also affect birth weight and size in zebu cattle (Bos primigenius indicus).
650 $abirth weight
653 $aBos primigenius indicus
653 $aGWAS
653 $aNellore cattle
653 $aStature
700 1 $aCARMO, A. S. do
700 1 $aCARVALHEIRO, R.
700 1 $aNEVES, H. H. R.
700 1 $aMATOS, M. C.
700 1 $aZAVAREZ, L. B.
700 1 $aO'BRIEN, A. M. P.
700 1 $aSÖLKNER, J.
700 1 $aMcEWAN, J. C.
700 1 $aCOLE, J. B.
700 1 $aTASSEL, C. P. V.
700 1 $aSCHENKEL, F. S.
700 1 $aSILVA, M. V. G. B.
700 1 $aPORTO NETO, L. R.
700 1 $aSONSTEGARD, T. S.
700 1 $aGARCIA, J. F.
773 $tBMC Genetics, London$gv. 14, article 52, 2013.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Gado de Leite (CNPGL) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
Registro Completo
|
Biblioteca(s): |
Embrapa Agroindústria Tropical. |
|
Data corrente: |
24/09/2019 |
|
Data da última atualização: |
24/09/2019 |
|
Tipo da produção científica: |
Comunicado Técnico/Recomendações Técnicas |
|
Autoria: |
SILVA, M. F. S.; SILVA, F. A. N.; SOUSA, A. D.; SILVA, L. M. A. e; RIBEIRO, P. R. V.; CANUTO, K. M.; BRITO, E. S. de; PESSOA, C. do Ó; ZOCOLO, G. J. |
|
Afiliação: |
Maria Francilene Souza Silva, Graduação em Ciências Biológicas, doutora em Biotecnologia-RENORBIO; Francisca Aliny Nunes Silva, Bacharel em Química com habilitação industrial, bolsista Embrapa Agroindústria Tropical; Adriana Dutra Sousa, Engenheira de alimentos, doutora em Engenharia Química-Universidade Federal do Ceará; LORENA MARA ALEXANDRE E SILVA, CNPAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; EDY SOUSA DE BRITO, CNPAT; Claudia do Ó Pessoa, bacharel em Farmácia Bioquímica, doutora em Farmacologia, professora associada IV-UFC e pesquisadora associada FIOCRUZ-CE, Bacharel em Farmácia Bioquímica, doutora em Farmacologia, professora associada IV-UFC e pesquisadora associada FIOCRUZ-CE; GUILHERME JULIAO ZOCOLO, CNPAT. |
|
Título: |
Metodologia baseada em extração em fase sólida (EFS) como parte da estratégia de desreplicação para prospecção de moléculas com atividade citotóxica em Phyllanthus spp. |
|
Ano de publicação: |
2019 |
|
Fonte/Imprenta: |
Fortaleza: Embrapa Agroindústria Tropical, 2019. |
|
Páginas: |
8 p. |
|
Série: |
(Embrapa Agroindústria Tropical. Comunicado técnico, 257) |
|
Idioma: |
Português |
|
Conteúdo: |
Extratos de espécies de Phyllanthus têm mostrado potencial terapêutico em muitos estudos clínicos, alguns com propriedades bastante estabelecidas, incluindo anti-hepatotóxico, antilítico, anti-hipertensivo, anti-HIV, anti-hepatite B e, mais recentemente, anticancerígeno. |
|
Palavras-Chave: |
Phyllanthus L. |
|
Categoria do assunto: |
-- |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/202263/1/CT-257.pdf
|
|
Marc: |
LEADER 01113nam a2200241 a 4500
001 2112427
005 2019-09-24
008 2019 bl uuuu u0uu1 u #d
100 1 $aSILVA, M. F. S.
245 $aMetodologia baseada em extração em fase sólida (EFS) como parte da estratégia de desreplicação para prospecção de moléculas com atividade citotóxica em Phyllanthus spp.$h[electronic resource]
260 $aFortaleza: Embrapa Agroindústria Tropical$c2019
300 $a8 p.
490 $a(Embrapa Agroindústria Tropical. Comunicado técnico, 257)
520 $aExtratos de espécies de Phyllanthus têm mostrado potencial terapêutico em muitos estudos clínicos, alguns com propriedades bastante estabelecidas, incluindo anti-hepatotóxico, antilítico, anti-hipertensivo, anti-HIV, anti-hepatite B e, mais recentemente, anticancerígeno.
653 $aPhyllanthus L
700 1 $aSILVA, F. A. N.
700 1 $aSOUSA, A. D.
700 1 $aSILVA, L. M. A. e
700 1 $aRIBEIRO, P. R. V.
700 1 $aCANUTO, K. M.
700 1 $aBRITO, E. S. de
700 1 $aPESSOA, C. do Ó
700 1 $aZOCOLO, G. J.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
