Data/hora: 10/06/2024 16:54:38

Biblioteca(s): | Embrapa Pantanal.
Data corrente: | 09/04/1996
Data da última atualização: | 03/04/2017
Autoria: | ASKONAS, B. A.; CORSINI, A. C.; CLAYTON, C. E.; OGILVIE, B. M.
Título: | Functional depletion of T- and B-memory cells and other lymphoid cell subpopulations during trypanosomiasis.
Ano de publicação: | 1979
Fonte/Imprenta: | Immunology, v.36, p.313-321, 1979.
Idioma: | Inglês
Conteúdo: | T. brucei in mice causes generalized immunosppression with multiple changes in the cells of the lymphoid tissue. Loss of B cell responsiveness to antigens and mitogens and the induction of suppressive T-cell and macrophages, have been previously reported (Hudson, Byner, Freeman & Terry, 1976; Corsini, Clayton, Askonas & Ogilvie, 1977; Jayawardena & Waksman, 1977). In this study, purified B- or T-cell populations from infected mice have been tested functionally in vitro or in vivo by transfer into syngeneic irradiated hosts to separate the cells from trypanosome or their products. B-memory cells for thymus dependent (DNP-KLH) and thymus independent (DNP-Ficoll) antigens are depleted or lose their potential to respond to the antigen during T. brucei infection. Similarly, purified T-helper cells, and T-cells reactive to allogeneic target cells in mixed lymphocyte reactions are functionally defective. By 16 days of infection all these responses are less than 10% of the normal level. The loss of B-cell function follows the peak parasitaemia and is accompanied by increases in the serum levels of both IgM and IgG. Enhanced Ig production and decline in B-cell potential also occur in T-deprived mice and in CBA/N mice which lack a subset of T-independent B-cells. Cells affecting delayed hypersensitivity reactions retain their activity throughout trypanosome infection and so far provide the only exception to the general decline in immune potential.
Thesaurus Nal: | Trypanosoma.
Categoria do assunto: | --
Registro original: | Embrapa Pantanal (CPAP)
Exemplares: | CPAP - (31490-1) - ADC - SP - PP - SP14777 -  - 14777 - DIS