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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Ocidental. Para informações adicionais entre em contato com cpaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
07/02/2024 |
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Data da última atualização: |
07/02/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ZUFFA, S.; SCHMID, R.; BAUERMEISTER, A.; GOMES, P. W. P.; CARABALLO-RODRIGUEZ, A. M.; EL ABIEAD, Y.; ARON, A. T.; GENTRY, E. C.; ZEMLIN, J.; MEEHAN, M. J.; AVALON, N. E.; CICHEWICZ, R. H.; BUZUN, E.; CARRILLO TERRAZAS, M.; HSU, C. Y.; OLES, R.; AYALA, A. V.; ZHAO, J.; CHU, H.; KUIJPERS, M. C. M.; JACKREL, S. L.; TUGIZIMANA, F.; NEPHALI, L. P.; DUBERY, I. A.; MADALA, N. E.; MOREIRA, E. A.; COSTA-LOTUFO, L. V.; LOPES, N. P.; REZENDE-TEIXEIRA, P.; JIMENEZ, P. C.; RIMAL, B.; PATTERSON, A. D.; TRAXLER, M. F.; PESSOTTI, R. de C.; ALVARADO-VILLALOBOS, D.; TAMAYO-CASTILLO, G.; CHAVERRI, P.; ESCUDERO-LEYVA, E.; QUIROS-GUERRERO, L. M.; BORY, A. J.; JOUBERT, J.; RUTZ, A.; WOLFENDER, J. L.; ALLARD, P. M.; SICHERT, A.; PONTRELLI, S.; PULLMAN, B. S.; BANDEIRA, N.; GERWICK, W. H.; GINDRO, K.; MASSANA-CODINA, J.; WAGNER, B. C.; FORCHHAMMER, K.; PETRAS, D.; AIOSA, N.; GARG, N.; LIEBEKE, M.; BOURCEAU, P.; KANG, K. B.; GADHAVI, H.; CARVALHO, L. P. S. de; SANTOS, M. S. dos; PÉREZ-LORENTE, A. I.; MOLINA-SANTIAGO, C.; ROMERO, D.; FRANKE, R.; BRÖNSTRUP, M.; PONCE DE LEÓN, A. V.; POPE, P. B.; LA ROSA, S. L.; LA BARBERA, G.; ROAGER, H. M.; LAURSEN, M. F.; HAMMERLE, F.; SIEWERT, B.; PEINTNER, U.; LICONA-CASSANI, C.; RODRIGUEZ-ORDUÑA, L.; RAMPLER, E.; HILDEBRAND, F.; KOELLENSPERGER, G.; SCHOENY, H.; HOHENWALLNER, K.; PANZENBOECK, L.; GREGOR, R.; O'NEILL, E. C.; ROXBOROUGH, E. T.; ODOI, J.; BALE, N. J.; DING, S.; DAMSTÉ, J. S. S.; GUAN, X. L.; CUI, J. J.; JU, K. S.; SILVA, D. B.; SILVA, F. M. R.; SILVA, G. F. da; KOOLEN, H. H. F.; GRUNDMANN, C.; CLEMENT, J. A.; MOHIMANI, H.; BRODERS, K.; McPHAIL, K. L.; OBER-SINGLETON, S. E.; RATH, C. M.; McDONALD, D.; KNIGHT, R.; WANG, M.; DORRESTEIN, P. C. |
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Afiliação: |
SIMONE ZUFFA, UNIVERSITY OF CALIFORNIA SAN DIEGO; ROBIN SCHMID, UNIVERSITY OF CALIFORNIA SAN DIEGO; ANELIZE BAUERMEISTER, UNIVERSITY OF CALIFORNIA SAN DIEGO; PAULO WENDER P. GOMES, UNIVERSITY OF CALIFORNIA SAN DIEGO; ANDRES M. CARABALLO-RODRIGUEZ, UNIVERSITY OF CALIFORNIA SAN DIEGO; YASIN EL ABIEAD, UNIVERSITY OF CALIFORNIA SAN DIEGO; ALLEGRA T. ARON, UNIVERSITY OF DENVER; EMILY C. GENTRY, DEPARTMENT OF CHEMISTRY, VIRGINIA TECH; JASMINE ZEMLIN, UNIVERSITY OF CALIFORNIA SAN DIEGO; MICHAEL J. MEEHAN, UNIVERSITY OF CALIFORNIA SAN DIEGO; NICOLE E. AVALON, UNIVERSITY OF CALIFORNIA SAN DIEGO; ROBERT H. CICHEWICZ, UNIVERSITY OF OKLAHOMA; EKATERINA BUZUN, UNIVERSITY OF CALIFORNIA SAN DIEGO; MARVIC CARRILLO TERRAZAS, UNIVERSITY OF CALIFORNIA SAN DIEGO; CHIA-YUN HSU, UNIVERSITY OF CALIFORNIA SAN DIEGO; RENEE OLES, UNIVERSITY OF CALIFORNIA SAN DIEGO; ADRIANA VASQUEZ AYALA, UNIVERSITY OF CALIFORNIA SAN DIEGO; JIAQI ZHAO, UNIVERSITY OF CALIFORNIA SAN DIEGO; HIUTUNG CHU, UNIVERSITY OF CALIFORNIA SAN DIEGO; MIRTE C. M. KUIJPERS, UNIVERSITY OF CALIFORNIA SAN DIEGO; SARA L. JACKREL, UNIVERSITY OF CALIFORNIA SAN DIEGO; FIDELE TUGIZIMANA, UNIVERSITY OF JOHANNESBURG; LERATO PERTUNIA NEPHALI, UNIVERSITY OF JOHANNESBURG; IAN A. DUBERY, UNIVERSITY OF JOHANNESBURG; NTAKADZENI EDWIN MADALA, UNIVERSITY OF VENDA; EDUARDA ANTUNES MOREIRA, UNIVERSIDADE DE SÃO PAULO; LETICIA VERAS COSTA-LOTUFO, UNIVERSIDADE DE SÃO PAULO; NORBERTO PEPORINE LOPES, UNIVERSIDADE DE SÃO PAULO; PAULA REZENDE-TEIXEIRA, UNIVERSIDADE DE SÃO PAULO; PAULA C. JIMENEZ, UNIVERSIDADE DE SÃO PAULO; BIPIN RIMAL, PENNSYLVANIA STATE UNIVERSITY; ANDREW D. PATTERSON, PENNSYLVANIA STATE UNIVERSITY; MATTHEW F. TRAXLER, UNIVERSITY OF CALIFORNIA BERKELEY; RITA DE CASSIA PESSOTTI, UNIVERSITY OF CALIFORNIA BERKELEY; DANIEL ALVARADO-VILLALOBOS, UNIVERSIDAD DE COSTA RICA; GISELLE TAMAYO-CASTILLO, UNIVERSIDAD DE COSTA RICA; PRISCILA CHAVERRI, UNIVERSIDAD DE COSTA RICA; EFRAIN ESCUDERO-LEYVA, UNIVERSIDAD DE COSTA RICA; LUIS-MANUEL QUIROS-GUERRERO, UNIVERSITY OF GENEVA; ALEXANDRE JEAN BORY, UNIVERSITY OF GENEVA; JULIETTE JOUBERT, UNIVERSITY OF GENEVA; ADRIANO RUTZ, UNIVERSITY OF GENEVA; JEAN-LUC WOLFENDER, UNIVERSITY OF GENEVA; PIERRE-MARIE ALLARD, UNIVERSITY OF GENEVA; ANDREAS SICHERT, INSTITUTE OF MOLECULAR SYSTEMS BIOLOGY; SAMMY PONTRELLI, INSTITUTE OF MOLECULAR SYSTEMS BIOLOGY; BENJAMIN S. PULLMAN, UNIVERSITY OF CALIFORNIA SAN DIEGO; NUNO BANDEIRA, UNIVERSITY OF CALIFORNIA SAN DIEGO; WILLIAM H. GERWICK, UNIVERSITY OF CALIFORNIA SAN DIEGO; KATIA GINDRO, PLANT PROTECTION, MYCOLOGY GROUP; JOSEP MASSANA-CODINA, PLANT PROTECTION, MYCOLOGY GROUP; BERENIKE C. WAGNER, UNIVERSITY OF TUEBINGEN; KARL FORCHHAMMER, UNIVERSITY OF TUEBINGEN; DANIEL PETRAS, UNIVERSITY OF TUEBINGEN; NICOLE AIOSA, GEORGIA INSTITUTE OF TECHNOLOGY; NEHA GARG, GEORGIA INSTITUTE OF TECHNOLOGY; MANUEL LIEBEKE, MAX PLANCK INSTITUTE FOR MARINE MICROBIOLOGY; PATRIC BOURCEAU, MAX PLANCK INSTITUTE FOR MARINE MICROBIOLOGY; KYO BIN KANG, SOOKMYUNG WOMEN’S UNIVERSITY; HENNA GADHAVI, THE FRANCIS CRICK INSTITUTE; LUIZ PEDRO SORIO DE CARVALHO, THE FRANCIS CRICK INSTITUTE; MARIANA SILVA DOS SANTOS, THE FRANCIS CRICK INSTITUTE; ALICIA ISABEL PÉREZ-LORENTE, UNIVERSIDAD DE MÁLAGA-CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS; CARLOS MOLINA-SANTIAGO, UNIVERSIDAD DE MÁLAGA-CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS; DIEGO ROMERO, UNIVERSIDAD DE MÁLAGA-CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS; RAIMO FRANKE, HELMHOLTZ CENTRE FOR INFECTION RESEARCH; MARK BRÖNSTRUP, HELMHOLTZ CENTRE FOR INFECTION RESEARCH; ARTURO VERA PONCE DE LEÓN, NORWEGIAN UNIVERSITY OF LIFE SCIENCES; PHILLIP BYRON POPE, NORWEGIAN UNIVERSITY OF LIFE SCIENCES; SABINA LEANTI LA ROSA, NORWEGIAN UNIVERSITY OF LIFE SCIENCES; GIORGIA LA BARBERA, UNIVERSITY OF COPENHAGEN; HENRIK M. ROAGER, UNIVERSITY OF COPENHAGEN; MARTIN FREDERIK LAURSEN, UNIVERSITY OF DENMARK; FABIAN HAMMERLE, UNIVERSITY OF INNSBRUCK; BIANKA SIEWERT, UNIVERSITY OF INNSBRUCK; URSULA PEINTNER, UNIVERSITY OF INNSBRUCK; CUAUHTEMOC LICONA-CASSANI, CENTRO DE BIOTECNOLOGÍA FEMSA, TECNOLOGICO DE MONTERREY; LORENA RODRIGUEZ-ORDUÑA, CENTRO DE BIOTECNOLOGÍA FEMSA, TECNOLOGICO DE MONTERREY; EVELYN RAMPLER, UNIVERSITY OF VIENNA; FELINA HILDEBRAND, UNIVERSITY OF VIENNA; GUNDA KOELLENSPERGER, UNIVERSITY OF VIENNA; HARALD SCHOENY, UNIVERSITY OF VIENNA; KATHARINA HOHENWALLNER, UNIVERSITY OF VIENNA; LISA PANZENBOECK, UNIVERSITY OF VIENNA; RACHEL GREGOR, MASSACHUSETTS INSTITUTE OF TECHNOLOGY; ELLIS CHARLES O'NEILL, UNIVERSITY OF NOTTINGHAM; EVE TALLULAH ROXBOROUGH, UNIVERSITY OF NOTTINGHAM; JANE ODOI, UNIVERSITY OF NOTTINGHAM; NICOLE J. BALE, NETHERLANDS INSTITUTE FOR SEA RESEARCH; SU DING, NETHERLANDS INSTITUTE FOR SEA RESEARCH; JAAP S. SINNINGHE DAMSTÉ, NETHERLANDS INSTITUTE FOR SEA RESEARCH; XUE LI GUAN, NANYANG TECHNOLOGICAL UNIVERSITY; JERRY J. CUI, THE OHIO STATE UNIVERSITY; KOU-SAN JU, THE OHIO STATE UNIVERSITY; DENISE BRENTAN SILVA, UNIVERSIDADE DO MATO GROSSO DO SUL; FERNANDA MOTTA RIBEIRO SILVA, UNIVERSIDADE DO MATO GROSSO DO SUL; GILVAN FERREIRA DA SILVA, CPAA; HECTOR H. F. KOOLEN, UNIVERSIDADE DO ESTADO DO AMAZONAS; CARLISMARI GRUNDMANN, UNIVERSIDADE DE SÃO PAULO; JASON A. CLEMENT, BARUCH S. BLUMBERG INSTITUTE; HOSEIN MOHIMANI, CARNEGIE MELLON UNIVERSITY; KIRK BRODERS, OREGON STATE UNIVERSITY; KERRY L. MCPHAIL, OREGON STATE UNIVERSITY; SIDNEE E. OBER-SINGLETON, UNIVERSITY OF OREGON; CHRISTOPHER M. RATH, UNIVERSITY OF CALIFORNIA SAN DIEGO; DANIEL MCDONALD, UNIVERSITY OF CALIFORNIA SAN DIEGO; ROB KNIGHT, UNIVERSITY OF CALIFORNIA SAN DIEGO; MINGXUN WANG, UNIVERSITY OF CALIFORNIA RIVERSIDE; PIETER C. DORRESTEIN, UNIVERSITY OF CALIFORNIA SAN DIEGO. |
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Título: |
MicrobeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Nature Microbiology, v. 9, p. 336-345, Feb. 2024. |
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DOI: |
https://doi.org/10.1038/s41564-023-01575-9 |
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Idioma: |
Inglês |
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Conteúdo: |
microbeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identifcation of microbe-derived metabolites and relative producers without a priori knowledge will vastly enhance the understanding of microorganisms' role in ecology and human health. |
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Palavras-Chave: |
Banco de dados; Ferramenta de pesquisa; Microbial. |
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Thesagro: |
Espectrometria. |
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Thesaurus Nal: |
Microorganisms. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 04475naa a2201489 a 4500
001 2161733
005 2024-02-07
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1038/s41564-023-01575-9$2DOI
100 1 $aZUFFA, S.
245 $aMicrobeMASST$ba taxonomically informed mass spectrometry search tool for microbial metabolomics data.$h[electronic resource]
260 $c2024
520 $amicrobeMASST, a taxonomically informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known and unknown MS/MS spectra and link them to their respective microbial producers via MS/MS fragmentation patterns. Identifcation of microbe-derived metabolites and relative producers without a priori knowledge will vastly enhance the understanding of microorganisms' role in ecology and human health.
650 $aMicroorganisms
650 $aEspectrometria
653 $aBanco de dados
653 $aFerramenta de pesquisa
653 $aMicrobial
700 1 $aSCHMID, R.
700 1 $aBAUERMEISTER, A.
700 1 $aGOMES, P. W. P.
700 1 $aCARABALLO-RODRIGUEZ, A. M.
700 1 $aEL ABIEAD, Y.
700 1 $aARON, A. T.
700 1 $aGENTRY, E. C.
700 1 $aZEMLIN, J.
700 1 $aMEEHAN, M. J.
700 1 $aAVALON, N. E.
700 1 $aCICHEWICZ, R. H.
700 1 $aBUZUN, E.
700 1 $aCARRILLO TERRAZAS, M.
700 1 $aHSU, C. Y.
700 1 $aOLES, R.
700 1 $aAYALA, A. V.
700 1 $aZHAO, J.
700 1 $aCHU, H.
700 1 $aKUIJPERS, M. C. M.
700 1 $aJACKREL, S. L.
700 1 $aTUGIZIMANA, F.
700 1 $aNEPHALI, L. P.
700 1 $aDUBERY, I. A.
700 1 $aMADALA, N. E.
700 1 $aMOREIRA, E. A.
700 1 $aCOSTA-LOTUFO, L. V.
700 1 $aLOPES, N. P.
700 1 $aREZENDE-TEIXEIRA, P.
700 1 $aJIMENEZ, P. C.
700 1 $aRIMAL, B.
700 1 $aPATTERSON, A. D.
700 1 $aTRAXLER, M. F.
700 1 $aPESSOTTI, R. de C.
700 1 $aALVARADO-VILLALOBOS, D.
700 1 $aTAMAYO-CASTILLO, G.
700 1 $aCHAVERRI, P.
700 1 $aESCUDERO-LEYVA, E.
700 1 $aQUIROS-GUERRERO, L. M.
700 1 $aBORY, A. J.
700 1 $aJOUBERT, J.
700 1 $aRUTZ, A.
700 1 $aWOLFENDER, J. L.
700 1 $aALLARD, P. M.
700 1 $aSICHERT, A.
700 1 $aPONTRELLI, S.
700 1 $aPULLMAN, B. S.
700 1 $aBANDEIRA, N.
700 1 $aGERWICK, W. H.
700 1 $aGINDRO, K.
700 1 $aMASSANA-CODINA, J.
700 1 $aWAGNER, B. C.
700 1 $aFORCHHAMMER, K.
700 1 $aPETRAS, D.
700 1 $aAIOSA, N.
700 1 $aGARG, N.
700 1 $aLIEBEKE, M.
700 1 $aBOURCEAU, P.
700 1 $aKANG, K. B.
700 1 $aGADHAVI, H.
700 1 $aCARVALHO, L. P. S. de
700 1 $aSANTOS, M. S. dos
700 1 $aPÉREZ-LORENTE, A. I.
700 1 $aMOLINA-SANTIAGO, C.
700 1 $aROMERO, D.
700 1 $aFRANKE, R.
700 1 $aBRÖNSTRUP, M.
700 1 $aPONCE DE LEÓN, A. V.
700 1 $aPOPE, P. B.
700 1 $aLA ROSA, S. L.
700 1 $aLA BARBERA, G.
700 1 $aROAGER, H. M.
700 1 $aLAURSEN, M. F.
700 1 $aHAMMERLE, F.
700 1 $aSIEWERT, B.
700 1 $aPEINTNER, U.
700 1 $aLICONA-CASSANI, C.
700 1 $aRODRIGUEZ-ORDUÑA, L.
700 1 $aRAMPLER, E.
700 1 $aHILDEBRAND, F.
700 1 $aKOELLENSPERGER, G.
700 1 $aSCHOENY, H.
700 1 $aHOHENWALLNER, K.
700 1 $aPANZENBOECK, L.
700 1 $aGREGOR, R.
700 1 $aO'NEILL, E. C.
700 1 $aROXBOROUGH, E. T.
700 1 $aODOI, J.
700 1 $aBALE, N. J.
700 1 $aDING, S.
700 1 $aDAMSTÉ, J. S. S.
700 1 $aGUAN, X. L.
700 1 $aCUI, J. J.
700 1 $aJU, K. S.
700 1 $aSILVA, D. B.
700 1 $aSILVA, F. M. R.
700 1 $aSILVA, G. F. da
700 1 $aKOOLEN, H. H. F.
700 1 $aGRUNDMANN, C.
700 1 $aCLEMENT, J. A.
700 1 $aMOHIMANI, H.
700 1 $aBRODERS, K.
700 1 $aMcPHAIL, K. L.
700 1 $aOBER-SINGLETON, S. E.
700 1 $aRATH, C. M.
700 1 $aMcDONALD, D.
700 1 $aKNIGHT, R.
700 1 $aWANG, M.
700 1 $aDORRESTEIN, P. C.
773 $tNature Microbiology$gv. 9, p. 336-345, Feb. 2024.
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Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
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Biblioteca |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
|
Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
21/08/2021 |
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Data da última atualização: |
21/08/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SILVA, N. P. da; PEREIRA, E. do C. R. L.; DUARTE, L. M.; FREITAS, J. C. de O.; ALMEIDA, C. G. de; SILVA, T. P. da; MELO, R. C. N.; APOLONIO, A. C. M.; OLIVEIRA, M. A. L. de; BRANDAO, H. de M.; PITTELLA, F.; FABRI, R. L.; TAVARES, G. D.; PINTO, P. de F. |
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Afiliação: |
NATALIA PRADO DA SILVA, Universidade Federal de Juiz de Fora; ELOA DO CARMO RAPOZO LAVINAS PEREIRA, Universidade Federal de Juiz de Fora; LUCAS MATTOS DUARTE, Universidade Federal de Juiz de Fora; JHAMINE CAROLINE DE OLIVEIRA FREITAS, Universidade Federal de Juiz de Fora; CAMILA GUIMARAES DE ALMEIDA; THIAGO PEREIRA DA SILVA, Universidade Federal de Juiz de Fora; ROSSANA C. N. MELO, Universidade Federal de Juiz de Fora; ANA CAROLINA MORAIS APOLONIO, Universidade Federal de Juiz de Fora; MARCONE AUGUSTO LEAL DE OLIVEIRA, Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; FREDERICO PITTELLA, Universidade Federal de Juiz de Fora; RODRIGO LUIZ FABRI, Universidade Federal de Juiz de Fora; GUILHERME DINIZ TAVARES, Universidade Federal de Juiz de Fora; PRISCILA DE FARIA PINTO, Universidade Federal de Juiz de Fora. |
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Título: |
Improved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Colloids and Surfaces B: Biointerfaces, v. 196, 111371, 2020. |
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DOI: |
https://doi.org/10.1016/j.colsurfb.2020.111371 |
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Idioma: |
Inglês |
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Conteúdo: |
The purpose of this study was to develop tea tree oil (TTO)-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules (NC-TTO-Ch) aiming the topical acne treatment. TTO was analyzed by gas chromatographymass spectrometry, and nanocapsules were characterized regarding mean particle size (Z-average), polydispersity index (PdI), zeta potential (ZP), pH, entrapment efficiency (EE), morphology by Atomic Force Microscopy (AFM), and anti-Cutibacterium acnes activity. The main constituents of TTO were terpinen-4-ol (37.11 %), ?-terpinene (16.32 %), ?-terpinene (8.19 %), ?-cimene (6.56 %), and ?-terpineol (6.07 %). NC-TTO-Ch presented Z-average of 268.0 ± 3.8 nm and monodisperse size distribution (PdI < 0.3). After coating the nanocapsules with chitosan, we observed an inversion in ZP to a positive value (+31.0 ± 1.8 mV). This finding may indicate the presence of chitosan on the nanocapsules? surface, which was corroborated by the AFM images. In addition, NC-TTO-Ch showed a slightly acidic pH (~5.0), compatible with topical application. The EE, based on Terpinen-4-ol concentration, was approximately 95 %. This data suggests the nanocapsules? ability to reduce the TTO volatilization. Furthermore, NC-TTO-Ch showed significant anti-C. acnes activity, with a 4× reduction in the minimum inhibitory concentration, compared to TTO and a decrease in C. acnes cell viability, with an increase in the percentage of dead cells (17 %) compared to growth control (6.6 %) and TTO (9.7 %). Therefore, chitosan-poly(?-caprolactone) core-shell nanocapsules are a promising tool for TTO delivery, aiming at the activity against C. acnes for the topical acne treatment. MenosThe purpose of this study was to develop tea tree oil (TTO)-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules (NC-TTO-Ch) aiming the topical acne treatment. TTO was analyzed by gas chromatographymass spectrometry, and nanocapsules were characterized regarding mean particle size (Z-average), polydispersity index (PdI), zeta potential (ZP), pH, entrapment efficiency (EE), morphology by Atomic Force Microscopy (AFM), and anti-Cutibacterium acnes activity. The main constituents of TTO were terpinen-4-ol (37.11 %), ?-terpinene (16.32 %), ?-terpinene (8.19 %), ?-cimene (6.56 %), and ?-terpineol (6.07 %). NC-TTO-Ch presented Z-average of 268.0 ± 3.8 nm and monodisperse size distribution (PdI < 0.3). After coating the nanocapsules with chitosan, we observed an inversion in ZP to a positive value (+31.0 ± 1.8 mV). This finding may indicate the presence of chitosan on the nanocapsules? surface, which was corroborated by the AFM images. In addition, NC-TTO-Ch showed a slightly acidic pH (~5.0), compatible with topical application. The EE, based on Terpinen-4-ol concentration, was approximately 95 %. This data suggests the nanocapsules? ability to reduce the TTO volatilization. Furthermore, NC-TTO-Ch showed significant anti-C. acnes activity, with a 4× reduction in the minimum inhibitory concentration, compared to TTO and a decrease in C. acnes cell viability, with an increase in the percentage of dead cells (17 %) compared to growth control (6.6 %) and TTO (9.7 %). Therefore... Mostrar Tudo |
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Palavras-Chave: |
Acne vulgaris; Core-shell nanocapsules; Nanocápsula; Quitosana-poli. |
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Thesagro: |
Árvore. |
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Thesaurus NAL: |
Chitosan; Tea tree oil. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 02808naa a2200373 a 4500
001 2133785
005 2021-08-21
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.colsurfb.2020.111371$2DOI
100 1 $aSILVA, N. P. da
245 $aImproved anti-Cutibacterium acnes activity of tea tree oil-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules.$h[electronic resource]
260 $c2020
520 $aThe purpose of this study was to develop tea tree oil (TTO)-loaded chitosan-poly(?-caprolactone) core-shell nanocapsules (NC-TTO-Ch) aiming the topical acne treatment. TTO was analyzed by gas chromatographymass spectrometry, and nanocapsules were characterized regarding mean particle size (Z-average), polydispersity index (PdI), zeta potential (ZP), pH, entrapment efficiency (EE), morphology by Atomic Force Microscopy (AFM), and anti-Cutibacterium acnes activity. The main constituents of TTO were terpinen-4-ol (37.11 %), ?-terpinene (16.32 %), ?-terpinene (8.19 %), ?-cimene (6.56 %), and ?-terpineol (6.07 %). NC-TTO-Ch presented Z-average of 268.0 ± 3.8 nm and monodisperse size distribution (PdI < 0.3). After coating the nanocapsules with chitosan, we observed an inversion in ZP to a positive value (+31.0 ± 1.8 mV). This finding may indicate the presence of chitosan on the nanocapsules? surface, which was corroborated by the AFM images. In addition, NC-TTO-Ch showed a slightly acidic pH (~5.0), compatible with topical application. The EE, based on Terpinen-4-ol concentration, was approximately 95 %. This data suggests the nanocapsules? ability to reduce the TTO volatilization. Furthermore, NC-TTO-Ch showed significant anti-C. acnes activity, with a 4× reduction in the minimum inhibitory concentration, compared to TTO and a decrease in C. acnes cell viability, with an increase in the percentage of dead cells (17 %) compared to growth control (6.6 %) and TTO (9.7 %). Therefore, chitosan-poly(?-caprolactone) core-shell nanocapsules are a promising tool for TTO delivery, aiming at the activity against C. acnes for the topical acne treatment.
650 $aChitosan
650 $aTea tree oil
650 $aÁrvore
653 $aAcne vulgaris
653 $aCore-shell nanocapsules
653 $aNanocápsula
653 $aQuitosana-poli
700 1 $aPEREIRA, E. do C. R. L.
700 1 $aDUARTE, L. M.
700 1 $aFREITAS, J. C. de O.
700 1 $aALMEIDA, C. G. de
700 1 $aSILVA, T. P. da
700 1 $aMELO, R. C. N.
700 1 $aAPOLONIO, A. C. M.
700 1 $aOLIVEIRA, M. A. L. de
700 1 $aBRANDAO, H. de M.
700 1 $aPITTELLA, F.
700 1 $aFABRI, R. L.
700 1 $aTAVARES, G. D.
700 1 $aPINTO, P. de F.
773 $tColloids and Surfaces B: Biointerfaces$gv. 196, 111371, 2020.
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