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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
09/06/2017 |
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Data da última atualização: |
09/06/2017 |
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Autoria: |
GLICKMAN, J. A.; PATRICK, J. E.; CHALLIS, J. R. G. |
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Título: |
Increase in the response to adrenocorticotrophin of isolated maternal adrenal cells from sheep in late pregnancy. |
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Ano de publicação: |
1980 |
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Fonte/Imprenta: |
Journal of Endocrinology, v. 86, n. 1, p. 93-100, Jul. 1980. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Adrenal cells were prepared from non-pregnant (anoestrous) sheep, from ewes at days 50, 100 and 130 of pregnancy and at term, and from animals at 1-5 days post partum. The ability of the cells to respond to adrenocorticotrophin (ACTH1-24), alpha-melanocyte-stimulating hormone (alpha-MSH), or combinations of these peptides has been examined in vitro. There was a progressive rise in the basal output of cortisol during pregnancy and in the absence of adrenocorticotrophin the cortisol output from adrenal cells of late pregnant and post-partum sheep the amount of ACTH required to produce half the maximum output of steroid (ED50) was 8 pg/ml. The ED50 increased in early pregnancy to 112 pg/ml and then fell to < 5 pg/ml between day 100 and term. At term both the stimulation ratio and the absolute increment in cortisol output elicited by a maximal concentration of ACTH were greater than at any other time tested in pregnant or non-pregnant sheep. Cortisol output during pregnancy was not increased by alpha-MSH, although at term the stimulatory effect of ACTH1-24 was partially antagonized by alpha-MSH. These results suggest that there may be an increase in the responsiveness of the maternal adrenal during pregnancy, although the factor(s) responsible remains unknown. |
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Palavras-Chave: |
Adrenocorticotropic hormone; Anoestrus; Drug effects; Hydrocortisone; Melanocyte-stimulating hormones; Stimuli. |
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Thesaurus Nal: |
Adrenal glands; Pharmacology; Pregnancy; Sheep. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02062naa a2200265 a 4500
001 2070674
005 2017-06-09
008 1980 bl uuuu u00u1 u #d
100 1 $aGLICKMAN, J. A.
245 $aIncrease in the response to adrenocorticotrophin of isolated maternal adrenal cells from sheep in late pregnancy.
260 $c1980
520 $aAbstract: Adrenal cells were prepared from non-pregnant (anoestrous) sheep, from ewes at days 50, 100 and 130 of pregnancy and at term, and from animals at 1-5 days post partum. The ability of the cells to respond to adrenocorticotrophin (ACTH1-24), alpha-melanocyte-stimulating hormone (alpha-MSH), or combinations of these peptides has been examined in vitro. There was a progressive rise in the basal output of cortisol during pregnancy and in the absence of adrenocorticotrophin the cortisol output from adrenal cells of late pregnant and post-partum sheep the amount of ACTH required to produce half the maximum output of steroid (ED50) was 8 pg/ml. The ED50 increased in early pregnancy to 112 pg/ml and then fell to < 5 pg/ml between day 100 and term. At term both the stimulation ratio and the absolute increment in cortisol output elicited by a maximal concentration of ACTH were greater than at any other time tested in pregnant or non-pregnant sheep. Cortisol output during pregnancy was not increased by alpha-MSH, although at term the stimulatory effect of ACTH1-24 was partially antagonized by alpha-MSH. These results suggest that there may be an increase in the responsiveness of the maternal adrenal during pregnancy, although the factor(s) responsible remains unknown.
650 $aAdrenal glands
650 $aPharmacology
650 $aPregnancy
650 $aSheep
653 $aAdrenocorticotropic hormone
653 $aAnoestrus
653 $aDrug effects
653 $aHydrocortisone
653 $aMelanocyte-stimulating hormones
653 $aStimuli
700 1 $aPATRICK, J. E.
700 1 $aCHALLIS, J. R. G.
773 $tJournal of Endocrinology$gv. 86, n. 1, p. 93-100, Jul. 1980.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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