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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
05/02/2019 |
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Data da última atualização: |
21/01/2020 |
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Tipo da produção científica: |
Artigo em Anais de Congresso |
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Autoria: |
SOUZA, M. M.; ZERLOTINI NETO, A.; NICIURA, S. C. M.; ROCHA, M. I. P.; DINIZ, W. J.; TIZIOTO, P. C.; OLIVEIRA, P. S. N.; LIMA, A. O.; AFONSO, J.; CESAR, A. S. M; COUTINHO, L. L.; REGITANO, L. C. de A. |
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Afiliação: |
M. M. SOUZA, CPPSE; ADHEMAR ZERLOTINI NETO, CNPTIA; SIMONE CRISTINA MEO NICIURA, CPPSE; MARINA IBELLI PEREIRA ROCHA, UFSCar; WELLISON JARLES DINIZ, UFSCar; POLYANA CRISTINE TIZIOTO, Esalq/USP; PRISCILA SILVA NEUBERN DE OLIVEIRA, Bolsista/CPPSE; A.O. LIMA, UFSCar; J. AFONSO, UFSCar; A. S. M. CESAR, CNPTIA; L. L. COUTINHO, CNPTIA; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Genome-wide distribution of allele-specific expression in Nelore steers muscle. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland. Proceedings... [S.l.: s.n.], 2018. |
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Páginas: |
5 p. |
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Idioma: |
Inglês |
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Notas: |
Na publicação: A. Zerlotini, L. C. A. Regitano. WCGALP 2018. |
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Conteúdo: |
Summary. The difference between the allelic expression of a gene is known as allele-specific expression (ASE), and it is a common event in mammal?s transcriptome. ASE is named genomic imprinting when guided by epigenetics mechanisms regarding the allele parental origin. Although these events are an important sources of phenotypic variation, knowledge thereof regarding cattle and effects on economically important traits are still incipient. Therefore, analysis and characterization of ASE profile in the muscle of adult Nelore animals were performed, and besides that, the ASE pattern and gene imprinting occurrence were checked in genes previously associated with meat tenderness. For this, RNA sequencing data of 146 Nelore steer muscles were used, and these animals were also genotyped for approximately 770,000 SNPs using Illumina BovineHD BeadChip. For each animal, a diploid genome was built based on their genotypes, and afterward, RNA-Seq reads were mapped to this genome. After counting the reads considering each SNP allele, a binomial test was applied to identify whether the allele contribution to total expression significantly diverged from 50%, followed by false discovery rate (FDR) test (0.05). Among 519 analyzed SNPs, 402 showed at least one sample with ASE, and they were spread among all autosomal chromosomes. SNPs showing ASE in more than five samples were tested regarding ASE extension, and most presented an incomplete pattern. Four ASE genes were previously identified in a Genome-Wide Association Study (GWAS) and five were found differentially expressed between extreme phenotype animals for meat tenderness. Therefore, the results will complement the bovine imprinted genes database, further they can provide new information to genetic effects prediction in animal breeding increasing the accuracy of meat tenderness selection. MenosSummary. The difference between the allelic expression of a gene is known as allele-specific expression (ASE), and it is a common event in mammal?s transcriptome. ASE is named genomic imprinting when guided by epigenetics mechanisms regarding the allele parental origin. Although these events are an important sources of phenotypic variation, knowledge thereof regarding cattle and effects on economically important traits are still incipient. Therefore, analysis and characterization of ASE profile in the muscle of adult Nelore animals were performed, and besides that, the ASE pattern and gene imprinting occurrence were checked in genes previously associated with meat tenderness. For this, RNA sequencing data of 146 Nelore steer muscles were used, and these animals were also genotyped for approximately 770,000 SNPs using Illumina BovineHD BeadChip. For each animal, a diploid genome was built based on their genotypes, and afterward, RNA-Seq reads were mapped to this genome. After counting the reads considering each SNP allele, a binomial test was applied to identify whether the allele contribution to total expression significantly diverged from 50%, followed by false discovery rate (FDR) test (0.05). Among 519 analyzed SNPs, 402 showed at least one sample with ASE, and they were spread among all autosomal chromosomes. SNPs showing ASE in more than five samples were tested regarding ASE extension, and most presented an incomplete pattern. Four ASE genes were previously identified ... Mostrar Tudo |
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Palavras-Chave: |
Allele-specific expression; Expressão gênica; Sequenciamento; Sequencing; Transcriptoma. |
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Thesagro: |
Gado Nelore; Melhoramento Genético Animal; Polimorfismo Genético. |
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Thesaurus Nal: |
Gene expression; Transcriptome. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 03082nam a2200385 a 4500
001 2105522
005 2020-01-21
008 2018 bl uuuu u01u1 u #d
100 1 $aSOUZA, M. M.
245 $aGenome-wide distribution of allele-specific expression in Nelore steers muscle.$h[electronic resource]
260 $aIn: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland. Proceedings... [S.l.: s.n.], 2018.$c2018
300 $a5 p.
500 $aNa publicação: A. Zerlotini, L. C. A. Regitano. WCGALP 2018.
520 $aSummary. The difference between the allelic expression of a gene is known as allele-specific expression (ASE), and it is a common event in mammal?s transcriptome. ASE is named genomic imprinting when guided by epigenetics mechanisms regarding the allele parental origin. Although these events are an important sources of phenotypic variation, knowledge thereof regarding cattle and effects on economically important traits are still incipient. Therefore, analysis and characterization of ASE profile in the muscle of adult Nelore animals were performed, and besides that, the ASE pattern and gene imprinting occurrence were checked in genes previously associated with meat tenderness. For this, RNA sequencing data of 146 Nelore steer muscles were used, and these animals were also genotyped for approximately 770,000 SNPs using Illumina BovineHD BeadChip. For each animal, a diploid genome was built based on their genotypes, and afterward, RNA-Seq reads were mapped to this genome. After counting the reads considering each SNP allele, a binomial test was applied to identify whether the allele contribution to total expression significantly diverged from 50%, followed by false discovery rate (FDR) test (0.05). Among 519 analyzed SNPs, 402 showed at least one sample with ASE, and they were spread among all autosomal chromosomes. SNPs showing ASE in more than five samples were tested regarding ASE extension, and most presented an incomplete pattern. Four ASE genes were previously identified in a Genome-Wide Association Study (GWAS) and five were found differentially expressed between extreme phenotype animals for meat tenderness. Therefore, the results will complement the bovine imprinted genes database, further they can provide new information to genetic effects prediction in animal breeding increasing the accuracy of meat tenderness selection.
650 $aGene expression
650 $aTranscriptome
650 $aGado Nelore
650 $aMelhoramento Genético Animal
650 $aPolimorfismo Genético
653 $aAllele-specific expression
653 $aExpressão gênica
653 $aSequenciamento
653 $aSequencing
653 $aTranscriptoma
700 1 $aZERLOTINI NETO, A.
700 1 $aNICIURA, S. C. M.
700 1 $aROCHA, M. I. P.
700 1 $aDINIZ, W. J.
700 1 $aTIZIOTO, P. C.
700 1 $aOLIVEIRA, P. S. N.
700 1 $aLIMA, A. O.
700 1 $aAFONSO, J.
700 1 $aCESAR, A. S. M
700 1 $aCOUTINHO, L. L.
700 1 $aREGITANO, L. C. de A.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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| Registros recuperados : 78 | |
| 41. |  | DEFANT, H.; MEIRA, A. N.; COUTINHO, L. L.; REGITANO, L. C. de A.; POLETI, M. D.; MOREIRA, G. C. M.; PADUAN, M.; MARIANI, P.; ZERLOTINI NETO, A.; MOURÃO, G. B.; CESAR, A. S. M. Novel polymorphisms in the PLIN2 gene of Nellore cattle. Genetics and Molecular Research, v. 18, n. 3, 2019. Não paginado. Na publicação: Luciana CA Regitano, Adhemar Zerlotini. gmr16039963.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 42. | | CONTRICIANI, R. E.; GRADE, C. V. C.; LEITE, I. B.; VEIGA, F. C. da; LEDUR, M. C.; REVERTER, A.; ALEXANDRE, P. A.; CESAR, A. S. M.; COUTINHO, L. L.; ALVARES, L. E. Phenotypic divergence between broiler and layer chicken lines is regulated at the molecular level during development. BMC Genomics, v. 25, n.168, 2024.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 43. | | OLIVEIRA, P. S. N. de; CESAR, A. S. M.; OLIVEIRA, G. B. de; TIZIOTO, P. C.; POLETI, M. D.; DINIZ, W. J. da S.; LIMA, A. O. de; REECY, J. M.; COUTINHO, L. L.; REGITANO, L. C. de A. miRNAs related to fatty acids composition in Nellore cattle. Journal of Animal Science, v. 94, e-suppl. 5; Journal of Dairy Science, v. 99, e-suppl. 1, p. 159, jul. 2016. p. 160.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 44. | | TREVISOLI, P. A.; MOREIRA, G. C. M.; BOSCHIERO, C.; CESAR, A. S. M.; PETRINI, J.; MARGARIDO, G. R. A.; LEDUR, M. C.; MOURÃO, G. B.; GARRICK, D.; COUTINHO, L. L. A missense mutation in the MYBPH gene is associated with abdominal fat traits in meat-type chickens. Frontiers in Genetics, v. 12, n. 698163, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 45. | | CESAR, A. S. M.; REGITANO, L. C. de A.; KOLTES, J.; FRITZ-WATERS, E. R.; TULLIO, R. R.; LANNA, D. P. D.; REECY, J. M.; MOURÃO, G. B.; GASPARIN, G.; COUTINHO, L. L. Transcriptome profile in Longissimus dorsi muscle from Nellore steers with extreme GEBV for intramuscular fat percentage. In: INTERNATIONAL SYMPOSIUM ON ANIMAL FUNCTIONAL GENOMICS, 5., 2013, Guarujá. Abstract... Guarujá:[ s.n.], 2013. AB.07.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 46. | | MOREIRA, G. C. M.; POLETI, M. D.; PÉRTILLE, F.; BOSCHIERO, C.; CESAR, A. S. M.; GODOY, T. F.; LEDUR, M. C.; REECY, J. M.; GARRICK, D. J.; COUTINHO, L. L. Unraveling genomic associations with feed efficiency and body weight traits in chickens through an integrative approach. BMC Genetics, v. 20, n. 83, 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 47. | | SOUZA, M. M.; MOKRY, F. C.; TIZIOTO, P. C.; OLIVEIRA, P. S. N.; SOMAVILLA, A.; CESAR, A. S. M.; MORÉ, D.; MOURÃO, G.; DINIZ, W. J. S.; MUDADU, M. A.; NICIURA, S. C. M.; COUTINHO, L. L.; ZERLOTINI NETO, A.; REGITANO, L. C. Allele specific expression analysis in bovine muscle tissue. In: ANNUAL INTERNACIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 23.; EUROPEAN CONFERENCE ON COMPUTATIONAL BIOLOGY, 14., 2015, Dublin. Posters... [S.l.]: International Society for Computacional Biology, [2015]. Não paginado. ISMB/ECCB 2015. Pôster D17.| Biblioteca(s): Embrapa Agricultura Digital. |
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| 48. | | SOUZA, M. M.; MOKRY, F. C.; TIZIOTO, P. C.; OLIVEIRA, P. S. N.; SOMAVILLA, A.; CESAR, A. S. M.; MORÉ, D.; MOURÃO, G.; DINIZ, W. J. S.; MUDADU, M. A.; NICIURA, S. C. M.; COUTINHO, L. L.; ZERLOTINI, A.; REGITANO, L. C. Allele specific expression analysis in bovine muscle tissue. In: INTERNATIONAL CONFERENCE OF THE AB3C, 11.; BRAZILIAN SYMPOSIUM OF BIOINFORMATICS, 2015, São Paulo. Proceedings... [S.l.]: AB3C, 2015. p. 197. X-meeting 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 49. | | SOUZA, M. M. de; ZERLOTINI NETO, A.; ROCHA, M. I. P.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; CARDOSO, T. F.; CESAR, A. S. M.; AFONSO, J.; ANDRADE, B. G. N.; MUDADU, M. de A.; MOKRY, F. B.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; NICIURA, S. C. M.; COUTINHO, L. L.; REGITANO, L. C. de A. Allele-specific expression is widespread in Bos indicus muscle and affects meat quality candidate genes. Scientific Reports, v. 10, n. 1, p. 1-11, 2020. Na publicação: Adhemar Zerlotini. Article number: 10204.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 50. | | CESAR, A. S. M.; REGITANO, L. C. de A.; POLETI, M. D.; ANDRADE, S. C. da S.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; LANNA, D. P. D.; TULLIO, R. R.; NASSU, R. T.; KOLTES, J. E.; WATERS, E. F.; REECY, J. M.; COUTINHO, L. L. Association of skeletal muscle transcripts with fatty acid content in Nellore cattle. In: INTERNATIONAL SOCIETY FOR ANIMAL GENETICS CONFERENCE, 35., 2016, Salt Lake City. Proceedings... Salt Lake City: ISAG, 2016.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 51. | | BUSS, C. E.; AFONSO, J.; OLIVEIRA, P. S. N. DE; PETRINI, J.; TIZIOTO, P. C.; CESAR, A. S. M.; GUSTANI-BUSS, E. C.; CARDOSO, T. F.; ROVADOSKI, G. A.; DINIZ, W. J. DA S.; LIMA, A. O. DE; ROCHA, M. I. P.; ANDRADE, B. G. N.; WOLF, J. B.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A. Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle. Mammalian Genome, v. 34, p. 90-103, dec. 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 4 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 52. | | SANTANA, M. H. de A.; OLIVEIRA JUNIOR, G. A.; CESAR, A. S. M.; FREUA, M. C.; GOMES, R. da C.; SILVA, S. da L.; LEME, P. R.; FUKUMASU, H.; CARVALHO, M. E.; VENTURA, R. V.; COUTINHO, L. L.; KADARMIDEEN, H. N.; FERRAZ, J. B. S. Copy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with the feed conversion ratio in beef cattle. Journal of Applied Gentics, v. 57, n. 4, p. 495-504, 2016| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 53. | | SOUZA, M. M.; ZERLOTINI NETO, A.; TIZIOTO, P. C.; OLIVEIRA, P. S. N.; SOMAVILLA, A. L.; MOKRY, F. B.; CESAR, A. S. M.; DINIZ, W. J. S.; MUDADU, M. de A.; NICIURA, S. C. M.; COUTINHO, L. L.; REGITANO, L. C. de A. Monoallelic expression of NNAT gene in Nelore steers skeletal muscle. In:WORLD CONGRESS OF GENETICS APPLIED TO LIVESTOK PRODUCTION, 10; . 2014, Vancouver. Proceedings... Vancouver: American Society of animal Science, 2014| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 54. | | OLIVEIRA, P. S. N. de; COUTINHO, L. L.; CESAR, A. S. M.; DINIZ, W. J. da S.; SOUZA, M. de S.; ANDRADE, B. G.; KOLTES, J. E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; REGITANO, L. C. de A. Co-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle. Frontiers in Genetics, v. 10, p. 1-14, July 2019. Article 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 55. | | CESAR, A. S. M.; REGITANO, L. C. de A.; MOURÃO, G. B.; TULLIO, R. R.; LANNA, D. P. D.; NASSU, R. T.; MUDADU, M. de A.; OLIVEIRA, P. S. N.; NASCIMENTO, M. L. do; CHAVES, A. S.; ALENCAR, M. M. de; SONSTEGRAD, T. S.; GARRICK, D. J.; REECY, J. M.; COUTINHO, L. L. Genome-wide association study for intramuscular fat deposition and composition in Nellore cattle. BMC Genetics, v. 15, p. 39, 2014| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 56. | | SOUZA, M. M.; ZERLOTINI NETO, A.; NICIURA, S. C. M.; ROCHA, M. I. P.; DINIZ, W. J.; TIZIOTO, P. C.; OLIVEIRA, P. S. N.; LIMA, A. O.; AFONSO, J.; CESAR, A. S. M; COUTINHO, L. L.; REGITANO, L. C. de A. Genome-wide distribution of allele-specific expression in Nelore steers muscle. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland. Proceedings... [S.l.: s.n.], 2018. 5 p. Na publicação: A. Zerlotini, L. C. A. Regitano. WCGALP 2018.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital. |
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| 57. | | SOUZA, M. M. de; ZERLOTINI NETO, A.; NICIURA, S. C. M.; ROCHA, M. I. P.; DINIZ, W. J.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; LIMA, A. O.; AFONSO, J.; CESAR, A. S. M; COUTINHO, L. L.; REGITANO, L. C. de A. Genome-wide distribution of allele-specific expression in Nelore steers muscle. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOOCK PRODUCTION, 2018, Auckland, New Zealand. proceedings... Auckland, New Zealand: Massey University, 2018, v. 892.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 58. | | AFONSO, J.; FORTES, M. R. S.; REVERTER, A.; DINIZ, W. J. da S.; CESAR, A. S. M.; LIMA, A. O. de; PETRINI, J.; SOUZA, M. de S.; COUTINHO, L. L.; MOURÃO, G. B.; ZERLOTINI NETO, A.; GROMBONI, C. F.; NOGUEIRA, A. R. A.; REGITANO, L. C. de A. Genetic regulators of mineral amount in Nelore cattle muscle predicted by a new co-expression and regulatory impact factor approach. Scientific Reports, v. 10, n. 1, p. 1-16, 2020 Article: 8436.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 59. | | NASCIMENTO, M. L.; SOUZA, A. R. D. L.; CHAVES, A. S.; CESAR, A. S. M.; TULLIO, R. R.; MEDEIROS, S. R. de; MOURÃO, G. B.; ROSA, A. do N.; FEIJO, G. L. D.; ALENCAR, M. M. de; LANNA, D. P. D. Feed efficiency indexes and their relationships with carcass, non-carcass and meat quality traits in Nellore steers. Meat Science, v. 116, p. 78-85, June, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Corte; Embrapa Pecuária Sudeste. |
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| 60. | | TIZIOTO, P. L.; COUTINHO, L. L.; OLIVEIRA, P. S. N.; CESAR, A. S. M.; DINIZ, W. J. S.; LIMA, A. O.; ROCHA, M. I.; DECKER, J. E.; SCHNABEL, R. D.; MOURÃO, G. B.; TULLIO, R. R.; ZERLOTINI NETO, A.; TAYLOR, J. F.; REGITANO, L. C. de A. Gene expression differences in Longissimus muscle of Nelore steers genetically divergent for residual feed intake. Scientific Reports, v. 6, p. 1-12, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| Registros recuperados : 78 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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