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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical; Embrapa Gado de Leite; Embrapa Instrumentação; Embrapa Pecuária Sudeste. |
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Data corrente: |
25/01/2024 |
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Data da última atualização: |
11/04/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ANHOLETO, L. A.; BRANCAGLION, G. A.; SANTOS, D. M. DOS; KAPRITCHKOFF, R. T. I.; CASTRO, K. N. de C.; CANUTO, K. M.; RODRIGUES, R. A. F.; CORREA, D. S.; CHAGAS, A. C. de S.; PASTRE, J. C. |
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Afiliação: |
LUIS ADRIANO ANHOLETO; GUILHERME ANDRADE BRANCAGLION, UNIVERSIDADE DE CAMPINAS; DANILO MARTINS DOS SANTOS; RAFAELA TAMI IKEDA KAPRITCHKOFF, UNIVERSIDADE DE SÃO PAULO; KARINA NEOOB DE CARVALHO CASTRO, CNPGL; KIRLEY MARQUES CANUTO, CNPAT; RODNEY ALEXANDRE FERREIRA RODRIGUES, UNIVERSIDADE DE CAMPINAS; DANIEL SOUZA CORREA, CNPDIA; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; JULIO CEZAR PASTRE, UNIVERSIDADE DE CAMPINAS. |
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Título: |
Acaricidal activity of synthetic spilanthol derivative against ticks of medical and veterinary importance. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
Veterinary Parasitology, v. 327, Apr. 2024, 110137. |
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Páginas: |
9 p. |
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DOI: |
10.1016/j.vetpar.2024.110137 |
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Idioma: |
Inglês |
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Conteúdo: |
The ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer and environmentally friendly. MenosThe ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer ... Mostrar Tudo |
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Palavras-Chave: |
Acmella oleracea; Bovine parasite sadness; Brazilian Spotted Fever; Cattle tick; Control; Nanoformulation; Spilanthol. |
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Thesagro: |
Bovino; Carrapato. |
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Thesaurus Nal: |
Rickettsia rickettsii. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02636naa a2200373 a 4500
001 2161314
005 2024-04-11
008 2024 bl uuuu u00u1 u #d
024 7 $a10.1016/j.vetpar.2024.110137$2DOI
100 1 $aANHOLETO, L. A.
245 $aAcaricidal activity of synthetic spilanthol derivative against ticks of medical and veterinary importance.$h[electronic resource]
260 $c2024
300 $a9 p.
520 $aThe ANESPSAT, a synthetic spilanthol derivative, and its nanoformulation were evaluated against Rhipicephalus microplus and Amblyomma sculptum ticks. ANESPSAT activity was compared with spilanthol and derivatives (ANESPE and others). The compound was synthesized in a gram-scale by a 2-step process, comprising a direct ester amidation and a Horner-Wadsworth- Emmons reaction. The nanoemulsions were produced by coarse homogenization followed by high-energy ultrasonication, in which hydrodynamic diameter, polydispersity index, and zeta potential remained stable. The spilanthol-eugenol hybrid derivatives did not show significant acaricidal activity. ANESPE killed 83% of the R. microplus larvae at 30 mg.mL−1, while ANESPSAT killed 97% at 0.5 mg.mL−1, showing to be the most active compound. Spilanthol and ANESPSAT had similar high mortality rates for tick larvae, with LC50 values of 0.10 and 0.14 mg.mL−1 for R. microplus larvae, and 0.04 and 0.48 mg.mL−1 for A. sculptum larvae, respectively. The efficacy of spilanthol was lower against R. microplus engorged females when compared with ANESPSAT, which was highly effective (>98%) against R. microplus engorged females. The nanoemulsion with ANESPSAT was effective against tick females, preventing egg laying and achieving 100% efficacy at 2.5 mg.mL−1. Spilanthol had only 59% efficacy at 10 mg.mL−1. The results suggest that ANESPSAT, a natural product derivative, could be used in novel formulations for tick management that might be safer and environmentally friendly.
650 $aRickettsia rickettsii
650 $aBovino
650 $aCarrapato
653 $aAcmella oleracea
653 $aBovine parasite sadness
653 $aBrazilian Spotted Fever
653 $aCattle tick
653 $aControl
653 $aNanoformulation
653 $aSpilanthol
700 1 $aBRANCAGLION, G. A.
700 1 $aSANTOS, D. M. DOS
700 1 $aKAPRITCHKOFF, R. T. I.
700 1 $aCASTRO, K. N. de C.
700 1 $aCANUTO, K. M.
700 1 $aRODRIGUES, R. A. F.
700 1 $aCORREA, D. S.
700 1 $aCHAGAS, A. C. de S.
700 1 $aPASTRE, J. C.
773 $tVeterinary Parasitology$gv. 327, Apr. 2024, 110137.
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Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
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Biblioteca |
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| Registros recuperados : 104 | |
| 1. |  | CASTRO, K. N. de C. Brucelose. Dourados: Embrapa Agropecuária Oeste, 2007. 1 folder. Documento on-line.| Tipo: Folder/Folheto/Cartilha |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 3. | | CASTRO, K. N. de C. Vantagens da ordenha com higiene. A Lavoura, ano 112, n. 675, p. 18-19, dez. 2009. SIDE 021/A - Portal Seagro, 18 fev. 2009; SIDE 021/09B - Portal do Agronegócio, 18 fev. 2009; SIDE 021/09C - Infobibos, 2009.; SIDE 21/09D - Dourados Informa, 18 fev. 2009; SIDE 021/09E - Cassilândia News, 2009; SIDE 021/09F - Agronline...| Tipo: Artigo de Divulgação na Mídia |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 5. | | CASTRO, K. N. de C.; HERNANI, L. C. Clara: a pequena guardiã da natureza. Dourados: Embrapa Agropecuária Oeste; Brasília, DF: Embrapa Informação tecnológica, 2007. 38 p. Texto em português e guarani; Ilustrações Isabel Cristina; Tradução e revisão do texto em guarani de Zélia Regina Benites (Kuná Tupã Verá).| Tipo: Autoria/Organização/Edição de Livros |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 7. | | CASTRO, K. N. de C.; GABRIEL, A. M. de A. Por que preocupar-se com a brucelose bovina? A Lavoura, Rio de Janeiro, ano 112, n. 671, p. 23-24, abr. 2009 SIDE 11/09A - MS Notícias, 17 fev. 2009; SIDE 11/09B - BBCNews, 17 fev. 2009; SIDE 11/09C - Notícias Agrícolas, 17 fev. 2009; SIDE 11/09D - Agro Rede Notícias, 17 fev. 2009; SIDE 11/09E - Peabirus, 17 fev. 2009; SIDE 11/09F - Grupo...| Tipo: Artigo de Divulgação na Mídia |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 11. | | CASTRO, K. N. de C.; PEREIRA, Z. V.; OLIVEIRA, E. R. Espécies nativas de interesse forrageiro para bovinos no cerrado de Mato Grosso do Sul. In: SEMINÁRIO DE AGROECOLOGIA DE MATO GROSSO DO SUL, 2., 2008, Dourados. A construção participativa da agroecologia em Mato Grosso do Sul: anais. Dourados: Embrapa Agropecuária Oeste, 2008. 1 CD-ROM. Organizado por: Alberto Feiden, Milton Parron Padovan, Adalgiza Inês Campolim, Aurélio Vinícius Borsato, Ivo de Sá Motta, João Batista Catto, Tércio Jacques Fehlauer.| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 16. | | CASTRO, K. N. de C.; ISHIKAWA, M. M.; CATTO, J. B.; NEGRÃO, F. J.; CASTRO, M. M. Avaliação de extratos de plantas no controle de Riphicephalus (Boophilus) microplus. In: SIMPÓSIO DE PLANTAS MEDICINAIS DO BRASIL, 20.; INTERNATIONAL CONGRESS OF ETHNOPHARMACOLOGY, 10., 2008, São Paulo. Annals and program / Programa e anais. São Paulo: Centro Brasileiro de Informação sobre Drogas Psicotrópicas: International Society of Ethnopharmacology: Laboratório de Etnofarmacologia da UFRGS, 2008. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 17. | | ANHOLETO, L. A.; OLIVEIRA, P. R. de; RODRIGUES, R. A. F.; CASTRO, K. N. de C.; CAMARGO MATHIAS, M. I. Ação do extrato etanólico bruto de Acmella oleracea em carrapatos Amblyomma cajennense (Acari: Ixodidae): avaliação ultraestrutural do sistema reprodutor masculino. In: In: SILVEIRA, M.; SILVA, E. da; LIMA, R. A. (Org.). Biodiversidade e Biotecnologia no Brasil 1. Rio Branco, AC: Strictu Sensu, 2020. cap. 5. p. 71-89.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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| 18. | | KASSAB, S. O.; LOUREIRO, E. de S.; NOGUERIA, F. F. da S.; CASTRO, K. N. de C. Avaliação da eficiência do fungo metarhizium anisopliae (metchnikoff, 1879), sobre telóginas do carrapato bovino Rhipicephalus (Boophilus) microplus (Canestrini, 1887) (Acari: ixodidae). In: CONGRESSO BRASILEIRO DE ENTOMOLOGIA, 22., 2008, Uberlândia. Ciência, tecnologia e inovação: anais. Viçosa: UFV, 2008. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agropecuária Oeste. |
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| 20. | | SILVA, M. R.; FERREIRA, F. C.; MARANHÃO, A. G.; LANZARINI, N. M.; CASTRO, K. N. de C.; MIAGOSTOVICH, M. P. Assessment of viral contamination of five Brazilian artisanal cheese produced from raw milk: a randomized survey. Food and Environmental Virology, v. 13, n. 4, p. 528-534, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Gado de Leite; Embrapa Tabuleiros Costeiros. |
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| Registros recuperados : 104 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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