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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
13/02/2017 |
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Data da última atualização: |
30/01/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARDOSO, R. C.; ALVES, B. R. C.; SHARPTON, S. M.; WILLIAMS, G. L.; AMSTALDEN, M. |
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Afiliação: |
R. C. CARDOSO, Texas A&M University, College Station, TX, USA; BRUNA RIOS COELHO ALVES, CNPGL; S. M. SHARPTON, Texas A&M University, College Station, TX, USA; G. L. WILLIAMS, Texas A&M University, College Station, TX, USA; M. AMSTALDEN, Texas A&M University, College Station, TX, USA. |
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Título: |
Nutritional Programming of Accelerated Puberty in Heifers: Involvement of Pro-Opiomelanocortin Neurones in the Arcuate Nucleus. |
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Ano de publicação: |
2015 |
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Fonte/Imprenta: |
Journal of Neuroendocrinology, n. 27, p. 647-657, 2015. |
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Idioma: |
Inglês |
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Conteúdo: |
The timing of puberty and subsequent fertility in female mammals are dependent on the inte-gration of metabolic signals by the hypothalamus. Pro-opiomelanocortin (POMC) neurones inthe arcuate nucleus (ARC) comprise a critical metabolic-sensing pathway controlling the reproductive neuroendocrine axis. a-Melanocyte-stimulating hormone (aMSH), a product of thePOMC gene, has excitatory effects on gonadotrophin-releasing hormone (GnRH) neurones andfibres containing aMSH project to GnRH and kisspeptin neurones. Because kisspeptin is a potentstimulator of GnRH release, aMSH may also stimulate GnRH secretion indirectly via kisspeptinneurones. In the present work, we report studies conducted in young female cattle (heifers) aiming to determine whether increased nutrient intake during the juvenile period (4-8 months ofage), a strategy previously shown to advance puberty, alters POMC and KISS1 mRNA expression, as well as aMSH close contacts on GnRH and kisspeptin neurones. In Experiment 1, POMCmRNA expression, detected by in situ hybridisation, was greater (P < 0.05) in the ARC in heifersthat gained 1 kg/day of body weight (high-gain, HG; n = 6) compared to heifers that gained0.5 kg/day (low-gain, LG; n = 5). The number of KISS1-expressing cells in the middle ARC was reduced (P < 0.05) in HG compared to LG heifers. In Experiment 2, double-immunofluorescence showed limited aMSH-positive close contacts on GnRH neurones, and the magnitude of these inputs was not influenced by nutritional status. Conversely, a large number of kisspeptin-immu-noreactive cells in the ARC were observed in close proximity to aMSH-containing varicosities. Furthermore, HG heifers (n = 5) exhibited a greater (P < 0.05) percentage of kisspeptin neuronesin direct apposition to aMSH fibres and an increased (P < 0.05) number of aMSH close contactsper kisspeptin cell compared to LG heifers (n = 6). These results indicate that the POMC-kisspeptin pathway may be important in mediating the nutritional acceleration of puberty inheifers. MenosThe timing of puberty and subsequent fertility in female mammals are dependent on the inte-gration of metabolic signals by the hypothalamus. Pro-opiomelanocortin (POMC) neurones inthe arcuate nucleus (ARC) comprise a critical metabolic-sensing pathway controlling the reproductive neuroendocrine axis. a-Melanocyte-stimulating hormone (aMSH), a product of thePOMC gene, has excitatory effects on gonadotrophin-releasing hormone (GnRH) neurones andfibres containing aMSH project to GnRH and kisspeptin neurones. Because kisspeptin is a potentstimulator of GnRH release, aMSH may also stimulate GnRH secretion indirectly via kisspeptinneurones. In the present work, we report studies conducted in young female cattle (heifers) aiming to determine whether increased nutrient intake during the juvenile period (4-8 months ofage), a strategy previously shown to advance puberty, alters POMC and KISS1 mRNA expression, as well as aMSH close contacts on GnRH and kisspeptin neurones. In Experiment 1, POMCmRNA expression, detected by in situ hybridisation, was greater (P < 0.05) in the ARC in heifersthat gained 1 kg/day of body weight (high-gain, HG; n = 6) compared to heifers that gained0.5 kg/day (low-gain, LG; n = 5). The number of KISS1-expressing cells in the middle ARC was reduced (P < 0.05) in HG compared to LG heifers. In Experiment 2, double-immunofluorescence showed limited aMSH-positive close contacts on GnRH neurones, and the magnitude of these inputs was not influenced by nutritional ... Mostrar Tudo |
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Palavras-Chave: |
Arcuate nucleus; Kisspeptin. |
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Thesaurus Nal: |
heifers; pro-opiomelanocortin; puberty. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02732naa a2200229 a 4500
001 2063904
005 2023-01-30
008 2015 bl uuuu u00u1 u #d
100 1 $aCARDOSO, R. C.
245 $aNutritional Programming of Accelerated Puberty in Heifers$bInvolvement of Pro-Opiomelanocortin Neurones in the Arcuate Nucleus.$h[electronic resource]
260 $c2015
520 $aThe timing of puberty and subsequent fertility in female mammals are dependent on the inte-gration of metabolic signals by the hypothalamus. Pro-opiomelanocortin (POMC) neurones inthe arcuate nucleus (ARC) comprise a critical metabolic-sensing pathway controlling the reproductive neuroendocrine axis. a-Melanocyte-stimulating hormone (aMSH), a product of thePOMC gene, has excitatory effects on gonadotrophin-releasing hormone (GnRH) neurones andfibres containing aMSH project to GnRH and kisspeptin neurones. Because kisspeptin is a potentstimulator of GnRH release, aMSH may also stimulate GnRH secretion indirectly via kisspeptinneurones. In the present work, we report studies conducted in young female cattle (heifers) aiming to determine whether increased nutrient intake during the juvenile period (4-8 months ofage), a strategy previously shown to advance puberty, alters POMC and KISS1 mRNA expression, as well as aMSH close contacts on GnRH and kisspeptin neurones. In Experiment 1, POMCmRNA expression, detected by in situ hybridisation, was greater (P < 0.05) in the ARC in heifersthat gained 1 kg/day of body weight (high-gain, HG; n = 6) compared to heifers that gained0.5 kg/day (low-gain, LG; n = 5). The number of KISS1-expressing cells in the middle ARC was reduced (P < 0.05) in HG compared to LG heifers. In Experiment 2, double-immunofluorescence showed limited aMSH-positive close contacts on GnRH neurones, and the magnitude of these inputs was not influenced by nutritional status. Conversely, a large number of kisspeptin-immu-noreactive cells in the ARC were observed in close proximity to aMSH-containing varicosities. Furthermore, HG heifers (n = 5) exhibited a greater (P < 0.05) percentage of kisspeptin neuronesin direct apposition to aMSH fibres and an increased (P < 0.05) number of aMSH close contactsper kisspeptin cell compared to LG heifers (n = 6). These results indicate that the POMC-kisspeptin pathway may be important in mediating the nutritional acceleration of puberty inheifers.
650 $aheifers
650 $apro-opiomelanocortin
650 $apuberty
653 $aArcuate nucleus
653 $aKisspeptin
700 1 $aALVES, B. R. C.
700 1 $aSHARPTON, S. M.
700 1 $aWILLIAMS, G. L.
700 1 $aAMSTALDEN, M.
773 $tJournal of Neuroendocrinology$gn. 27, p. 647-657, 2015.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 9 | |
| 2. |  | CARDOSO, R. C. D.; CARVALHO, J. E. U. de; BARBOSA, W. C. Caracterização físico-química das frações polpa aderida às sementes e segmentos partenocárpicos do Bacuri (Platonia insignis Mart.). In: CONGRESSO BRASILEIRO DE FRUTICULTURA, 17., 2002, Belém, PA. Anais. Belém: SBF, 2002. 4f. Publicado também: FRAZÃO, D. A. C.; HOMMA, A. K. O; VIÉGAS, I. de J. M. (Ed.). Contribuição ao desenvolvimento da fruticultura na Amazônia. Belém, PA: Embrapa Amazônia Oriental, 2006. p. 143-149.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 3. | | CARDOSO, R. C. D.; CARVALHO, J. E. U. de; BARBOSA, W. C. Caracterização física e físico-química da marirana (Couepia subcordata Benth.). In: CONGRESSO NACIONAL DE BOTÂNICA, 54.; REUNIÃO AMAZÔNICA DE BOTÂNICA, 3., 2003, Belém, PA. Botânica: desafios da botânica brasileira no novo milênio: inventário, sistematização, conservação e uso da diversidade vegetal: resumos. Belém, PA: Sociedade Botânica do Brasil: UFRA: Museu Paraense Emílio Goeldi: Embrapa Amazônia Oriental, 2003. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Amazônia Oriental. |
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| 7. | | ALVES, B. R. C.; CARDOSO, R. C.; DOAN, R.; Gary L. Williams; DINDOT, S. V.; AMSTALDEN, M. Nutritional Programming of Accelerated Puberty in Heifers: Alterations in DNA Methylation in the Arcuate Nucleus. In: ANNUAL MEETING OF THE SOCIETY FOR THE STUDY OF REPRODUCTION, 48., 2015, San Juan, Puerto Rico, USA. Evolution of sex: abstracts. San Juan: SSR, 2015. p. 117| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 8. | | MADRUGA, A. M.; MATOS, A. J.; BIANCHINI, B. D.; CARDOSO, R. C.; GONZAGA, S. S.; CORRÊA, G. F. Oficinas de cortes de ovinos: uma ação de extensão. Anais do Salão Internacional de Ensino, Pesquisa e Extensão, Bagé, v. 7, n. 3, 2015.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 9. | | YOUWEN, Z.; NEIL, O.; SCARPA, J. O.; ALVES, B. R. C.; WELSH JR, T. J.; CARDOSO, R. C.; WILLIAMS, G. L. Perinatal nutrition alters NPY neuronal projection do GuRH neurons and loptin receptor expression in the croid plexus of prepubertal heifers. In: ANNUAL MEETING OF THE SOCIETY FOR THE STUDY OF REPRODUTION, 50., 2017. Proceedings... Washington: [s.n.], 2017.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 9 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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