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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Pecuária Sul; Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
17/11/2020 |
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Data da última atualização: |
17/11/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CAVANI, L.; BRAZ, C. U.; GIGLIOTI, R.; OKINO, C. H.; GULIAS GOMES, C. C.; CAETANO, A. R.; OLIVEIRA, M. C. de S.; CARDOSO, F. F.; OLIVEIRA, H. N. de. |
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Afiliação: |
LIGIA CAVANI, UNESP; CAMILA URBANO BRAZ, UNESP; RODRIGO GIGLIOTI, Instituto de Zootecnia; CINTIA HIROMI OKINO, CPPSE; CLAUDIA CRISTINA GULIAS GOMES, CPPSUL; ALEXANDRE RODRIGUES CAETANO, Cenargen; MARCIA CRISTINA DE SENA OLIVEIRA, CPPSE; FERNANDO FLORES CARDOSO, CPPSUL; HENRIQUE NUNES DE OLIVEIRA, UNESP. |
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Título: |
Genomic study of Babesia bovis infection level and its association with tick count in Hereford and Braford cattle. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Frontiers in Immunology, v. 11, article 1905, aug. 2020. |
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Páginas: |
11 p. |
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DOI: |
https://doi.org/10.3389/fimmu.2020.01905 |
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Idioma: |
Inglês |
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Conteúdo: |
Bovine babesiosis is a tick-borne disease caused by intraerythrocytic protozoa and leads to substantial economic losses for the livestock industry throughout the world. Babesia bovis is considered the most pathogenic species, which causes bovine babesiosis in Brazil. Genomic data could be used to evaluate the viability of improving resistance against B. bovis infection level (IB) through genomic selection, and, for that, knowledge of genetic parameters is needed. Furthermore, genome-wide association studies (GWAS) could be conducted to provide a better understanding of the genetic basis of the host response to B. bovis infection. No previous work in quantitative genetics of B. bovis infection was found. Thus, the objective of this study was to estimate the genetic correlation between IB and tick count (TC), evaluate predictive ability and applicability of genomic selection, and perform GWAS in Hereford and Braford cattle. The single-step genomic best linear unbiased prediction method was used, which allows the estimation of both breeding values and marker effects. Standard phenotyping was conducted for both traits. IB quantifications from the blood of 1,858 animals were carried using quantitative PCR assays. For TC, one to three subsequent tick counts were performed by manually counting adult female ticks on one side of each animal's body that was naturally exposed to ticks. Animals were genotyped using the Illumina BovineSNP50 panel. The posterior mean of IB heritability, estimated by the Bayesian animal model in a bivariate analysis, was low (0.10), and the estimations of genetic correlation between IB and TC were also low (0.15). The cross-validation genomic prediction accuracy for IB ranged from 0.18 to 0.35 and from 0.29 to 0.32 using k-means and random clustering, respectively, suggesting that genomic predictions could be used as a tool to improve genetics for IB, especially if a larger training population is developed. The top 10 single nucleotide polymorphisms from the GWAS explained 5.04% of total genetic variance for IB, which were located on chromosomes 1, 2, 5, 6, 12, 17, 18, 16, 24, and 26. Some candidate genes participate in immunity system pathways indicating that those genes are involved in resistance to B. bovis in cattle. Although the genetic correlation between IB and TC was weak, some candidate genes for IB were also reported in tick infestation studies, and they were also involved in biological resistance processes. This study contributes to improving genetic knowledge regarding infection by B. bovis in cattle. MenosBovine babesiosis is a tick-borne disease caused by intraerythrocytic protozoa and leads to substantial economic losses for the livestock industry throughout the world. Babesia bovis is considered the most pathogenic species, which causes bovine babesiosis in Brazil. Genomic data could be used to evaluate the viability of improving resistance against B. bovis infection level (IB) through genomic selection, and, for that, knowledge of genetic parameters is needed. Furthermore, genome-wide association studies (GWAS) could be conducted to provide a better understanding of the genetic basis of the host response to B. bovis infection. No previous work in quantitative genetics of B. bovis infection was found. Thus, the objective of this study was to estimate the genetic correlation between IB and tick count (TC), evaluate predictive ability and applicability of genomic selection, and perform GWAS in Hereford and Braford cattle. The single-step genomic best linear unbiased prediction method was used, which allows the estimation of both breeding values and marker effects. Standard phenotyping was conducted for both traits. IB quantifications from the blood of 1,858 animals were carried using quantitative PCR assays. For TC, one to three subsequent tick counts were performed by manually counting adult female ticks on one side of each animal's body that was naturally exposed to ticks. Animals were genotyped using the Illumina BovineSNP50 panel. The posterior mean of IB heritability, e... Mostrar Tudo |
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Palavras-Chave: |
Bovine babesiosis; Cross validation; Genetic parameters; Genome wide association studies; Genomic selection. |
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Thesagro: |
Babesia Bovis. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/217858/1/GenomicStudyBabesia.pdf
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Marc: |
LEADER 03546naa a2200313 a 4500
001 2126663
005 2020-11-17
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3389/fimmu.2020.01905$2DOI
100 1 $aCAVANI, L.
245 $aGenomic study of Babesia bovis infection level and its association with tick count in Hereford and Braford cattle.$h[electronic resource]
260 $c2020
300 $a11 p.
520 $aBovine babesiosis is a tick-borne disease caused by intraerythrocytic protozoa and leads to substantial economic losses for the livestock industry throughout the world. Babesia bovis is considered the most pathogenic species, which causes bovine babesiosis in Brazil. Genomic data could be used to evaluate the viability of improving resistance against B. bovis infection level (IB) through genomic selection, and, for that, knowledge of genetic parameters is needed. Furthermore, genome-wide association studies (GWAS) could be conducted to provide a better understanding of the genetic basis of the host response to B. bovis infection. No previous work in quantitative genetics of B. bovis infection was found. Thus, the objective of this study was to estimate the genetic correlation between IB and tick count (TC), evaluate predictive ability and applicability of genomic selection, and perform GWAS in Hereford and Braford cattle. The single-step genomic best linear unbiased prediction method was used, which allows the estimation of both breeding values and marker effects. Standard phenotyping was conducted for both traits. IB quantifications from the blood of 1,858 animals were carried using quantitative PCR assays. For TC, one to three subsequent tick counts were performed by manually counting adult female ticks on one side of each animal's body that was naturally exposed to ticks. Animals were genotyped using the Illumina BovineSNP50 panel. The posterior mean of IB heritability, estimated by the Bayesian animal model in a bivariate analysis, was low (0.10), and the estimations of genetic correlation between IB and TC were also low (0.15). The cross-validation genomic prediction accuracy for IB ranged from 0.18 to 0.35 and from 0.29 to 0.32 using k-means and random clustering, respectively, suggesting that genomic predictions could be used as a tool to improve genetics for IB, especially if a larger training population is developed. The top 10 single nucleotide polymorphisms from the GWAS explained 5.04% of total genetic variance for IB, which were located on chromosomes 1, 2, 5, 6, 12, 17, 18, 16, 24, and 26. Some candidate genes participate in immunity system pathways indicating that those genes are involved in resistance to B. bovis in cattle. Although the genetic correlation between IB and TC was weak, some candidate genes for IB were also reported in tick infestation studies, and they were also involved in biological resistance processes. This study contributes to improving genetic knowledge regarding infection by B. bovis in cattle.
650 $aBabesia Bovis
653 $aBovine babesiosis
653 $aCross validation
653 $aGenetic parameters
653 $aGenome wide association studies
653 $aGenomic selection
700 1 $aBRAZ, C. U.
700 1 $aGIGLIOTI, R.
700 1 $aOKINO, C. H.
700 1 $aGULIAS GOMES, C. C.
700 1 $aCAETANO, A. R.
700 1 $aOLIVEIRA, M. C. de S.
700 1 $aCARDOSO, F. F.
700 1 $aOLIVEIRA, H. N. de
773 $tFrontiers in Immunology$gv. 11, article 1905, aug. 2020.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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Biblioteca |
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Origem |
Tipo/Formato |
Classificação |
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Registro |
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URL |
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| Registros recuperados : 411 | |
| 361. |  | SANTIAGO, G. G.; SIQUEIRA, F.; CARDOSO, F. F.; REGITANO, L. C. de A.; VENTURA, R.; SOLLERO, B. P.; Souza, M. D.; MOKRY, F. B.; FERREIRA, A. B. R.; TORRES JUNIOR, R. A. de A. Genomewide association study for production and meat quality traits in Canchim beef cattle. Journal Animal Science, v. 95, n. 8, p. 3381-3390, Aug. 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Gado de Corte; Embrapa Pecuária Sudeste. |
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| 362. | | SANTIAGO, G. G.; SIQUEIRA, F.; REGITANO, L. C. de A.; CARDOSO, F. F.; S. JÚNIOR, M. D.; GARCIA, J. F.; FERREIRA, A. B. R.; BLECHA, I. M. Z.; TORRES JUNIOR, R. A. de A. Genome wide association study for production traits in canchim breed. In: INTERNATIONAL SYMPOSIUM ON ANIMAL FUNCTIONAL GENOMICS, 5., 2013, Guarujá. Programme and abstract book... [S.l.: s.n.], 2013.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Corte; Embrapa Pecuária Sul. |
|  |
| 363. | | SANTIAGO, G. G.; SIQUEIRA, F.; REGITANO, L. C. de A.; CARDOSO, F. F.; SOUZA JÚNIOR, M. D.; GARCIA, J. F.; FERREIRA, A. B. R.; BLECHA, I. M. Z.; TORRES JUNIOR, R. A. de A. Genome wide association study for production traits in canchim breed. In: INTERNATIONAL SYMPOSIUM ON ANIMAL FUNCTIONAL GENOMICS, 5., 2013, Guarujá. Abstract... Guarujá:[ s.n.], 2013. AB.04.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 364. | | ERNST, C. W.; STEIBEL, J. P.; ROSA, G. J. M.; TEMPELMAN, R. J.; BATES, R. O.; RILINGTON, V. D.; RAGAVENDRAN, A.; RANEY, N. E.; RAMOS, A. M.; CARDOSO, F. F.; EDWARDS, D. B. Genome-wide expression QTL (eQYL) analysis of loin muscle tissue to identify candidate genes in pigs. In: ADSA CSAS ASAS JOINT ANNUAL MEETING, 2009, Montreal. Electronic abstracts... Champaign: ADSA: ASAS, 2009. LB4. Publicado em: Jornal of Animal Science, Champaign, v. 87, p. ii, 2009. Electronic Supplement 2.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 365. | | STEIBEL, J. P.; BATES, R. O.; ROSA, G. J. M.; TEMPELMAN, R. J.; RILINGTON, V. D.; RAGAVENDRAM, A.; RANEY, N. E.; RAMOS, A. M.; CARDOSO, F. F.; EDWARDS, D. B.; ERNST, C. W. Genome-wide linkage analysis of gene expression of loin muscle tissue identifies candidate genes in pigs. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 9., 2010, Leipzig. Proceedings... Leipzig: German Society of Animal Science, 2010. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 366. | | STEIBEL, J. P.; BATES, R. O.; ROSA, G. J. M.; TEMPELMAN, R. J.; RILINGTON, V. D.; RAGAVENDRAN, A.; RANEY, NANCY E.; RAMOS, A. M.; CARDOSO, F. F.; EDWARDS, D. B.; ERNST, C. W. Genome-wide linkage analysis of global gene expression in loin muscle tissue identifies candidate genes in pigs. PLoS ONE, San Francisco, v. 6, n. 2, e16766, Feb. 2011.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 367. | | MENEZES, G. R. de O.; REGITANO, L. C. de A.; SILVA, M. V. G. B.; CARDOSO, F. F.; SILVA, L. O. C. da; SIQUEIRA, F.; EGITO, A. A. do. Genômica aplicada ao melhoramento de gado de corte. In: ROSA, A. do N.; MARTINS. E. N.; MENEZES, G. R. de O.; SILVA, L. O. C. da (Ed.). Melhoramento genético aplicado em gado de corte: Programa Geneplus-Embrapa. Brasília, DF: Embrapa; Campo Grande, MS: Embrapa Gado de Corte, 2013. Capítulo 17. p. 213-225.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Gado de Corte; Embrapa Pecuária Sudeste. |
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| 368. | | MENEZES, G. R. de O.; REGITANO, L. C. de A.; SILVA, M. V. G. B.; CARDOSO, F. F.; SILVA, L. O. C. da; SIQUEIRA, F.; EGITO, A. A. do. Genômica aplicada ao melhoramento genético de gado de corte. In: ROSA, A. DO N.; MARTINS, E. N.; MENEZES, G. R. DE O.; SILVA, L. O. C. DA. Melhoramento genético aplicado em gado de corte: programa GENEPLUS-Embrapa. Brasília: Embrapa, 2013. p. 213-225. cap. 17| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 369. | | MORÉ, D. D.; MALAGO JUNIOR, W.; MUDADU, M. de A.; ZERLOTINI NETO, A.; GULIAS-GOMES, C. C.; IBELLI, A. M. G.; CATOIA, V.; CARDOSO, F. F.; REGITANO, L. C. de A. Genetics mechanisms of resistance and response to tick infestation in Hereford cattle: a global view. In: INTERNATIONAL SYMPOSIUM ON ANIMAL FUNCTIONAL GENOMICS, 5., 2013, Guarujá. Abstract... Guarujá:[ s.n.], 2013. AB.59.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste; Embrapa Pecuária Sul. |
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| 370. | | CARDOSO, F. F.; GOMES, C. C. G.; SOLLERO, B. P.; OLIVEIRA, M. M.; ROSO, V. M.; PICCOLI, M. L.; HIGA, R. H.; YOKOO, M. J.; CAETANO, A. R.; AGUILLAR, I. Genomic prediction for tick resistance in Braford and Hereford cattle. Journal of Animal Science, v. 93, n. 6, p. 2693-2705, June 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sul; Embrapa Recursos Genéticos e Biotecnologia. |
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| 371. | | CAMPOS, G. S.; REIMANN, F. A.; CARDOSO, L. L.; FERREIRA, C. E. R.; JUNQUEIRA, V. S.; SCHMIDT, P. I.; BRACCINI NETO, J.; YOKOO, M. J. I.; SOLLERO, B. P.; BOLIGON, A. A.; CARDOSO, F. F. Genomic prediction using different estimation methodology, blending and cross-validation techniques for growth traits and visual scores in Hereford and Braford cattle. Journal of Animal Science, v.96, n. 7, p. 2579-2595, June 2018.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 372. | | CARDOSO, F. F.; GULIAS-GOMES, C. C.; OLIVEIRA, M. M.; ROSO, V. M.; PICCOLI, M. L.; BRITO, F. V.; HIGA, R. H.; PAIVA, S. R.; SILVA, M. V. G. B.; REGITANO, L. C. de A.; YOKOO, M. J. I. Genomic selection for tick resistance in Braford and Hereford cattle using single-step methodology. In: CONFERENCE OF THE INTERNATIONAL SOCIETY FOR ANIMAL GENETICS, 33., 2012, Cairns. Programme and abstract book... Cairns: ISAG, 2012. p. 97-98.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 373. | | CAVANI, L.; BRAZ, C. U.; GIGLIOTI, R.; OKINO, C. H.; GULIAS GOMES, C. C.; CAETANO, A. R.; OLIVEIRA, M. C. de S.; CARDOSO, F. F.; OLIVEIRA, H. N. de. Genomic study of Babesia bovis infection level and its association with tick count in Hereford and Braford cattle. Frontiers in Immunology, v. 11, article 1905, aug. 2020. 11 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Pecuária Sul; Embrapa Recursos Genéticos e Biotecnologia. |
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| 374. | | SANTIAGO, G. G.; SIQUEIRA, F.; REGITANO, L. C. de A.; CARDOSO, F. F.; SOUZA JUNIOR, M. D.; GARCIA, J. F.; FERREIRA, A. B. R.; BLECHA, I. M. Z.; TORRES JUNIOR, R. A. de A. Identificação de regiões cromossômicas e de genes associados com características de produção e qualidade de carne em bovinos de corte. In: JORNADA CIENTÍFICA EMBRAPA GADO DE CORTE, 9., 2013, Campo Grande, MS. [Anais da..]. Campo Grande, MS: Embrapa Gado de Corte, 2013. (Embrapa Gado de Corte. Documentos, 204). Comissão organizadora: Denise Baptaglin Montagner, Grácia Maria Soares Rosinha, Rodrigo Carvalho Alva.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 375. | | SANTIAGO, G. G.; SIQUEIRA, F.; REGITANO, L. C. de A.; CARDOSO, F. F.; SOUZA JUNIOR, M. D.; GARCIA, J. F.; FERREIRA, A. B. R.; BLECHA, I. M. Z.; TORRES JUNIOR, R. A. de A. Identificação de regiões cromossômicas e de genes associados com características de produção e qualidade de carne em bovinos de corte. In: JORNADA CIENTÍFICA EMBRAPA GADO DE CORTE, 9., 2013, Campo Grande, MS. [Anais da..]. Campo Grande, MS: Embrapa Gado de Corte, 2013. (Embrapa Gado de Corte. Documentos, 204). Comissão organizadora: Denise Baptaglin Montagner, Grácia Maria Soares Rosinha, Rodrigo Carvalho Alva.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Corte. |
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| 376. | | IBELLI, A. M. G.; GIACHETTO, P. F.; CARDOSO, F. F.; HIGA, R. H.; YAMAGISHI, M. E. B.; OLIVEIRA, M. C. de S.; RIBEIRO, A. R. B.; TIZIOTO, P. C.; REGITANO, L. C. de A. Identification of new genes in cattle of different genetic groups activated in response to tick Rhipicephalus (Boophilus) microplus. In: REUNIÓN DE LA ASOCIACIÓN LATINOAMERICANA DE PRODUCCIÓN ANIMAL, 22., 2011, Montevideo, Uruguay. Memorias... Montevideo: Asociación Uruguaya de Producción Animal, 2011. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 377. | | IBELLI, A. M. G.; GIACHETTO, P. F.; CARDOSO, F. F.; HIGA, R. H.; YAMAGISHI, M. E. B.; OLIVEIRA, M. C. de S.; RIBEIRO, A. R. B.; TIZIOTO, P. C.; REGITANO, L. C. de A. Identification of new genes in cattle of different genetic groups activated in response to tick Rhipicephalus (Boophilus) microplus. Archivos Latinoamericano de Producion Animal, v. 19, (supl. 1), p. 221, 2011| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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| 378. | | MENEZES, G. R. de O.; REGITANO, L. C. de A.; SILVA, M. V. G. B.; CARDOSO, F. F.; SILVA, L. O. C. da; SIQUEIRA, F.; EGITO, A. A. do. Genômica aplicada ao melhoramento genético de gado de corte. In: ROSA, A. DO N.; MARTINS, E. N.; MENEZES, G. R. DE O.; SILVA, L. O. C. DA. Melhoramento genético aplicado em gado de corte: programa GENEPLUS-Embrapa. BrasÃlia: Embrapa, 2013. cap. 17| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 379. | | MARTINS, M. F.; FONSECA, I.; PINTO, I. S. B.; SANTOS, A. S. O.; VIEIRA, F. O.; MARTINS, S. A. V.; FOGAÇA, G. N.; LIMA, K. R.; CARDOSO, F. F.; GUIMARÃES, S. E. F. Gene expression profile of AATK in milk cells from dairy Gyr cows infected with Streptococcus agalactiae. In: CONGRESSO BRASILEIRO DE GENÉTICA, 59., 2013, Águas de Lindóia. Resumos... Ribeirão Preto: SBG, 2013. p. 187.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| 380. | | MARTINS, M. F.; PINTO, I. S. B.; SANTOS, A. S. O.; VIEIRA, F. O.; MARTINS, S. A. V.; FOGAÇA, G. N.; LIMA, K. R.; CARDOSO, F. F.; GUIMARÃES, S. E. F. Gene expression profile of AATK in milk cells from dairy gyr cows infected with Streptococcus agalactiae. In: CONGRESSO BRASILEIRO BRASILEIRO DE GENÉTICA, 59., 2013, Águas de Lindóia. Resumos... Águas de Lindóia: Sociedade Brasileira de Genética, 2013.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| Registros recuperados : 411 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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