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 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
19/09/2018 |
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Data da última atualização: |
20/09/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MOREIRA, G. C. M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; TREVISOLI, P. A.; CANTAO, M. E.; LEDUR, M. C.; IBELLI, A. M. G.; MOURA, A. S. M. T.; GARRICK, D.; COUTINHO, L. L. |
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Afiliação: |
GABRIEL COSTA MONTEIRO MOREIRA, ESALQ; CLARISSA BOSCHIERO, ESALQ; ALINE SILVA MELLO CESAR, ESALQ; JAMES M. REECY; THAÍS FERNANDA GODOY, USP/ESALq; PRISCILA ANCHIETA TREVISOLI, USP/ESALq; MAURICIO EGIDIO CANTAO, CNPSA; MONICA CORREA LEDUR, CNPSA; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; ANA SILVIA ALVES MEIRA TAVARES MOURA, USP/ESALq; DORIAN GARRICK, USP/ESALq; LUIZ LEHMMAN COUTINHO, USP/ESALq. |
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Título: |
A genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
BMC Genomics, v. 19, n. 374, 2018. |
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DOI: |
10.1186/s12864-018-4779-6 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract Background: Excess fat content in chickens has a negative impact on poultry production. The discovery of QTL associated with fat deposition in the carcass allows the identification of positional candidate genes (PCGs) that might regulate fat deposition and be useful for selection against excess fat content in chicken’s carcass. This study aimed to estimate genomic heritability coefficients and to identify QTLs and PCGs for abdominal fat (ABF) and skin (SKIN) traits in a broiler chicken population, originated from the White Plymouth Rock and White Cornish breeds. Results: ABF and SKIN are moderately heritable traits in our broiler population with estimates ranging from 0.23 to 0.33. Using a high density SNP panel (355,027 informative SNPs), we detected nine unique QTLs that were associated with these fat traits. Among these, four QTL were novel, while five have been previously reported in the literature. Thirteen PCGs were identified that might regulate fat deposition in these QTL regions: JDP2, PLCG1, HNF4A, FITM2, ADIPOR1, PTPN11, MVK, APOA1, APOA4, APOA5, ENSGALG00000000477, ENSGALG00000000483, and ENSGALG00000005043. We used sequence information from founder animals to detect 4843 SNPs in the 13 PCGs. Among those, two were classified as potentially deleterious and two as high impact SNPs. Conclusions: This study generated novel results that can contribute to a better understanding of fat deposition in chickens. The use of high density array of SNPs increases genome coverage and improves QTL resolution than would have been achieved with low density. The identified PCGs were involved in many biological processes that regulate lipid storage. The SNPs identified in the PCGs, especially those predicted as potentially deleterious and high impact, may affect fat deposition. Validation should be undertaken before using these SNPs for selection against carcass fat accumulation and to improve feed efficiency in broiler chicken production. MenosAbstract Background: Excess fat content in chickens has a negative impact on poultry production. The discovery of QTL associated with fat deposition in the carcass allows the identification of positional candidate genes (PCGs) that might regulate fat deposition and be useful for selection against excess fat content in chicken’s carcass. This study aimed to estimate genomic heritability coefficients and to identify QTLs and PCGs for abdominal fat (ABF) and skin (SKIN) traits in a broiler chicken population, originated from the White Plymouth Rock and White Cornish breeds. Results: ABF and SKIN are moderately heritable traits in our broiler population with estimates ranging from 0.23 to 0.33. Using a high density SNP panel (355,027 informative SNPs), we detected nine unique QTLs that were associated with these fat traits. Among these, four QTL were novel, while five have been previously reported in the literature. Thirteen PCGs were identified that might regulate fat deposition in these QTL regions: JDP2, PLCG1, HNF4A, FITM2, ADIPOR1, PTPN11, MVK, APOA1, APOA4, APOA5, ENSGALG00000000477, ENSGALG00000000483, and ENSGALG00000005043. We used sequence information from founder animals to detect 4843 SNPs in the 13 PCGs. Among those, two were classified as potentially deleterious and two as high impact SNPs. Conclusions: This study generated novel results that can contribute to a better understanding of fat deposition in chickens. The use of high density array of SNPs increases geno... Mostrar Tudo |
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Thesagro: |
Frango de Corte; Gordura; Hereditariedade; Melhoramento Genético Animal; Peso. |
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Thesaurus Nal: |
Animal genetics; Broiler chickens; Genomics; Heritability; Quantitative genetics; Quantitative trait loci. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03132naa a2200397 a 4500
001 2096061
005 2018-09-20
008 2018 bl uuuu u00u1 u #d
024 7 $a10.1186/s12864-018-4779-6$2DOI
100 1 $aMOREIRA, G. C. M.
245 $aA genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens.$h[electronic resource]
260 $c2018
520 $aAbstract Background: Excess fat content in chickens has a negative impact on poultry production. The discovery of QTL associated with fat deposition in the carcass allows the identification of positional candidate genes (PCGs) that might regulate fat deposition and be useful for selection against excess fat content in chicken’s carcass. This study aimed to estimate genomic heritability coefficients and to identify QTLs and PCGs for abdominal fat (ABF) and skin (SKIN) traits in a broiler chicken population, originated from the White Plymouth Rock and White Cornish breeds. Results: ABF and SKIN are moderately heritable traits in our broiler population with estimates ranging from 0.23 to 0.33. Using a high density SNP panel (355,027 informative SNPs), we detected nine unique QTLs that were associated with these fat traits. Among these, four QTL were novel, while five have been previously reported in the literature. Thirteen PCGs were identified that might regulate fat deposition in these QTL regions: JDP2, PLCG1, HNF4A, FITM2, ADIPOR1, PTPN11, MVK, APOA1, APOA4, APOA5, ENSGALG00000000477, ENSGALG00000000483, and ENSGALG00000005043. We used sequence information from founder animals to detect 4843 SNPs in the 13 PCGs. Among those, two were classified as potentially deleterious and two as high impact SNPs. Conclusions: This study generated novel results that can contribute to a better understanding of fat deposition in chickens. The use of high density array of SNPs increases genome coverage and improves QTL resolution than would have been achieved with low density. The identified PCGs were involved in many biological processes that regulate lipid storage. The SNPs identified in the PCGs, especially those predicted as potentially deleterious and high impact, may affect fat deposition. Validation should be undertaken before using these SNPs for selection against carcass fat accumulation and to improve feed efficiency in broiler chicken production.
650 $aAnimal genetics
650 $aBroiler chickens
650 $aGenomics
650 $aHeritability
650 $aQuantitative genetics
650 $aQuantitative trait loci
650 $aFrango de Corte
650 $aGordura
650 $aHereditariedade
650 $aMelhoramento Genético Animal
650 $aPeso
700 1 $aBOSCHIERO, C.
700 1 $aCESAR, A. S. M.
700 1 $aREECY, J. M.
700 1 $aGODOY, T. F.
700 1 $aTREVISOLI, P. A.
700 1 $aCANTAO, M. E.
700 1 $aLEDUR, M. C.
700 1 $aIBELLI, A. M. G.
700 1 $aMOURA, A. S. M. T.
700 1 $aGARRICK, D.
700 1 $aCOUTINHO, L. L.
773 $tBMC Genomics$gv. 19, n. 374, 2018.
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Registro original: |
Embrapa Suínos e Aves (CNPSA) |
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| Registros recuperados : 148 | |
| 101. |  | SAVOLDI, I. R.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; MORES, M. A. Z.; LAGOS, E. B.; LOPES, J. S.; ZANELLA, R.; LEDUR, M. C. A joint analysis using exome and transcriptome data identifiescandidate polymorphisms and genes involved with umbilical hernia in pigs. BMC Genomics, v. 22, n. 818, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 102. | | ZANELLA, J. R. C.; SCHAEFER, R.; GAVA, D.; KLEIN, C. S.; CANTAO, M. E.; SILVA, V. S.; MORES, M. A. Z.; SILVA, M. C. da; MORES, N.; RECH, R. R.; CARON, L. Influenza A virus infection on swine in Brazil. O Biológico, São Paulo, v. 75, p. 32, 2013. Suplemento 2, ref. 30. Edição dos Resumos do 3 Encontro Nacional de Defesa Sanitária Animal, Foz de Iguaçu, dez. 2013.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 103. | | ROMANO, G. de S.; IBELLI, A. M. G.; LORENZETTI, W. R.; WEBER, T.; PEIXOTO, J. de O.; CANTAO, M. E.; MORES, M. A. Z.; MORÉS, N.; PEDROSA, V. B.; COUTINHO. L. L.; LEDUR, M. C. Inguinal ring RNA sequencing reveals downregulation of muscular genes related to scrotal hernia in pigs. Genes, v. 11, n. 117, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 104. | | ONO, R. K.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; SOLLERO, B. P.; SUREK, D.; MOREIRA, G. C. M.; GODOY, T. F.; COUTINHO, L. L.; LEDUR, M. C. Genome-wide association study for femur-related traits in broilers. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University, 2018. Digital Archive.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 105. | | ZANELLA, R.; MORES, N.; MORES, M. A. Z.; PEIXOTO, J. de O.; ZANELLA, E. L.; ZANELLA, J. R. C.; IBELLI, A. M. G.; GAVA, D.; CANTAO, M. E.; LEDUR, M. C. Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs. Veterinary Record, v. 178, n. 26, p. 1-7, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 106. | | ZANELLA, R.; MORES, N.; MORES, M. A. Z.; PEIXOTO, J. de O.; ZANELLA, E. L.; ZANELLA, J. R. C.; IBELLI, A. M. G.; GAVA, D.; CANTAO, M. E.; LEDUR, M. C. Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in swine suggests genes involved with depression. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 24., Dublin. Abstracts Book... Dublin, Ireland: IPVS, 2016. p. 352.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 107. | | MOREIRA, G. C. M.; BOSCHIERO, C.; CESAR, A. S. M.; REECY, J. M.; GODOY, T. F.; TREVISOLI, P. A.; CANTAO, M. E.; LEDUR, M. C.; IBELLI, A. M. G.; MOURA, A. S. M. T.; GARRICK, D.; COUTINHO, L. L. A genome-wide association study reveals novel genomic regions and positional candidate genes for fat deposition in broiler chickens. BMC Genomics, v. 19, n. 374, 2018.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 108. | | FERNANDES, A. C.; SILVA, V. H. da; GOES, C. P.; MOREIRA, G. C. M.; GODOY, T. F.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; LEDUR, M. C.; REZENDE, F. M. de; COUTINHO, L. L. Genome-wide detection of CNVs and their association with performance traits in broilers. BMC Genomics, v. 22, n. 354, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 109. | | IBELLI, A. M. G.; SALMÓRIA, L. A.; TAVERNARI, F. de C.; PEIXOTO, J. de O.; MARCELINO, D. E. P.; DAL PIZZOL, M. S.; CANTAO, M. E.; LEDUR, M. C. Identificação e caracterização de variantes funcionais no transcriptoma de duodeno em poedeiras. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL ON-LINE, 14., 2021. Anais.... Chapecó: UDESC: Concórdia: Embrapa Suínos e Aves, 2022.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 110. | | KOWACIC, R. da C.; IBELLI, A. M. G.; PEIXOTO, J. de O.; MORES, N.; MORES, M. A. Z.; CANTAO, M. E.; SAVOLDI, I. R.; CARMO, K. B. do; COUTINHO, L. L.; LEDUR, M. C. Genes Col16A1 e ANGPT4 são menos expressos em suínos afetados com osteocondrose latens. In: JORNADA DE INICIAÇÃO CIENTÍFICA, 10., 2016, Concórdia. Anais... Concórdia: Embrapa Suínos e Aves: UNC, 2017. p. 15-16. JINC.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 111. | | ROMANO, G. de S.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; WEBER, T.; MORES, M. A. Z.; MORES, N.; PEDROSA, V. B.; PINTO, L. F. B.; COUTINHO, L. L.; LEDUR, M. C. Genes diferencialmente expressos no transcriptoma de suínos normais e afetados com hérnia escrotal. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 12., 2017, Ribeirão Preto. Anais... Ribeirão Preto: SBMA, 2017. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 112. | | RODRIGUES, A. F. G.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; OLIVEIRA, H. C. de; SAVOLDI, I. R.; SOUZA, M. R.; MORES, M. A. Z.; CARREÑO, L. O. D.; LEDUR, M. C. Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs. Genes, v. 12, n. 166, 2021.| Tipo: Artigo em Periódico Indexado |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 113. | | JOAQUIM, L. B.; CHUD, T. C. S.; MARCHESI, J. A. P.; SAVEGNAGO, R. P.; BUZANKAS, M. E.; ZANELLA, R.; CANTAO, M. E.; PEIXOTO, J. de O.; LEDUR, M. C.; IRGANG, R.; MUNARI, D. P. Genomic structure of a crossbred landrace pig population. Plos One, v. 14, n.2, e0212266, 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 114. | | PANDOLFI, J. R. C.; IBELLI, A. M. G.; CANTAO, M. E.; PEIXOTO, J. de O.; KRABBE, E. L.; AVILA, V. S. de; KRAMER, B.; ZANELLA, R.; JAENISCH, F. R. F.; MORES, M. A. Z.; COUTINHO, L. L.; LEDUR, M. C. Genetic characterization of poultry gut microbiota by 16S-rRNA gene sequencing. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 28., 2015, Florianópolis. Resumos. Florianópolis: Sociedade Brasileira de Microbiologia, 2015.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 115. | | DAL PIZZOL, M. S.; IBELLI, A. M. G.; CANTAO, M. E.; CAMPOS, F. G.; OLIVEIRA, H. C. de; PEIXOTO, J. de O.; FERNANDES, L. T.; TAVERNARI, F. de C.; MORES, M. A. Z.; BASTOS, A. P. A.; LEDUR, M. C. Differential expression of miRNAs associated with pectoral myopathies in young broilers: insights from a comparative transcriptome analysis. BMC Genomics, v. 25, n. 104, p. 1-14, 2024.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Suínos e Aves. |
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| 116. | | HUL, L. M.; IBELLI, A. M. G.; SAVOLDI, I. R.; MARCELINO, D. E. P.; FERNANDES, L. T.; PEIXOTO, J. O.; CANTAO, M. E.; HIGA, R. H.; GIACHETTO, P. F.; COUTINHO, L. L.; LEDUR, M. C. Differentially expressed genes in the femur cartilage transcriptome clarify the understanding of femoral head separation in chickens. Scientific Reports, v. 11, n. 1, p. 1-13. 2021. Article number: 17965.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agricultura Digital; Embrapa Suínos e Aves. |
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| 117. | | ROMANO, G. de S.; IBELLI, A. M. G.; PEIXOTO, J. de O.; CANTAO, M. E.; WEBER, T.; MORES, M. A. Z.; MORES, N.; PEDROSA, V. B.; COUTINHO, L. L.; LEDUR, M. C. Descobertas de variantes envolvidas na ocorrência de hérnia escrotal em suínos pela análise do exoma. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL, 13., 2019, Salvador. Anais... Salvador: SBMA, 2019. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 118. | | IBELLI, A. M. G.; PEIXOTO, J. de O.; ZANELLA, R.; GOUVEIA, J. J. de S.; CANTAO, M. E.; COUTINHO, L. L.; MARCHESI, J. A. P.; DAL PIZZOL, M. S.; MARCELINO, D. E. P.; LEDUR, M. C. Downregulation of growth plate genes involved with the onset of femoral head separation in young broilers. Frontiers in Physiology, v. 3, n. 941134, 2022. doi: 10.3389/fphys.2022.941134| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 119. | | FERNANDES, L. T.; PEIXOTO, J. de O.; DAL PIZZOL, M. S.; IBELLI, A. M. G.; MORES, M. A. Z.; TAVERNARI, F. de C.; COLDEBELLA, A.; CANTAO, M. E.; LEDUR, M. C. Effects of age, line and diet on the occurrence of white striping lesions in broiler breast muscle. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 12., 2022, Rotterdam. Proceedings: technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen: Wageningen Academic Publishers, 2022. Edited by R. F. Veerkamp and Y. de Haas.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 120. | | SALMÓRIA, L. A.; IBELLI, A. M. G.; TAVERNARI, F. de C.; PEIXOTO, J. de O.; MARCELINO, D. E. P.; DAL PIZZOL, M. S.; CANTAO, M. E.; LEDUR, M. C. Expressão diferencial de genes relacionados ao metabolismo de cálcio e fósforo em poedeiras com diferentes níveis de desempenho. In: SIMPÓSIO BRASILEIRO DE MELHORAMENTO ANIMAL ON-LINE, 14., 2021. Anais.... Chapecó: UDESC: Concórdia: Embrapa Suínos e Aves, 2022.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| Registros recuperados : 148 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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