Data/hora: 16/06/2024 09:40:55

Biblioteca(s): | Embrapa Agricultura Digital.
Data corrente: | 15/01/2016
Data da última atualização: | 21/01/2020
Autoria: | SILVA, J. M. da; ROMANIUC, A. R.; CAETANO, A. R.; GIACHETTO, P. F.; YAMAGISHI, M. E. B.
Afiliação: | JOAQUIM MANOEL DA SILVA, Unemat; ALAN ROBERTO ROMANIUC, CNPTIA; ALEXANDRE RODRIGUES CAETANO, CENARGEN; POLIANA FERNANDA GIACHETTO, CNPTIA; MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA.
Título: | Java Merging Copy Number Variants (JM-CNV): a new algorithm for identifying Copy Number Variant Regions (CNVR).
Ano de publicação: | 2015
Fonte/Imprenta: | In: PLANT & ANIMAL GENOME CONFERENCE, 23., 2015, San Diego, CA. [Abstracts...]. San Diego: [s.n.], 2015.
Páginas: | Não paginado.
Idioma: | Inglês
Notas: | PAG 2015. Pôster P1170.
Conteúdo: | CNVs (Copy Number Variations) are defined as copy number variations of DNA fragments typically larger than one kilobase (Kb), but less than five megabases (Mb). They represent a genomic disequilibrium that alters the ploidy in a specific locus within an individual, which may also be observed with varying frequencies within a population. An initial study estimated that 12% of the human genome shows this type of structural variation. Reliable tools have been developed to detect CNVs from molecular data produced with three main platforms: Comparative Genomic Hybridization (CGH) arrays, Single Nucleotide Polymorphism (SNP) genotyping arrays, and DNA Next-Generation Sequencing (NGS). However, processes for merging overlapping CNVs into a meaningful set of discrete Copy Number Variable Regions (CNVRs) need improvement, particularly when several CNV patterns co-exist within the same genomic locus. Available algorithms frequently merge noncontiguous CNVRs or fragment large CNVRs into multiple regions. A new web-based software (Java Merging Copy Number Variants: JM-CNV) was developed to address the aforementioned issues.
Palavras-Chave: | Bioinformática; Copy Number Variations.
Thesaurus Nal: | Bioinformatics; Computer software.
Categoria do assunto: | X Pesquisa, Tecnologia e Engenharia
URL: | http://ainfo.cnptia.embrapa.br/digital/bitstream/item/137048/1/Java-Silva-PAG.pdf
Registro original: | Embrapa Agricultura Digital (CNPTIA)
Exemplares: | CNPTIA - (18586-1) - UPC - RA - DD -  -  -  - DIS