Data/hora: 23/06/2024 23:37:25

Biblioteca(s): | Embrapa Alimentos e Territórios.
Data corrente: | 09/05/2023
Data da última atualização: | 29/02/2024
Autoria: | SABINO, L. B. de S.; COPES, F.; SAULAIS, S.; BRITO, E. S. de; SILVA JÚNIOR, I. J. da; LE, T. C.; MATEESCU, M. A.; MANTOVANI, D.
Afiliação: | LUIZ BRUNO DE SOUSA SABINO, UFC; FRANCESCO COPES, Laval University; SOLÈNE SAULAIS, Université du Québec à Montréal; EDY SOUSA DE BRITO, CNAT; IVANILDO JOSÉ DA SILVA JÚNIOR, UFC; TIEN CANH LE, Université du Québec à Montréal; MIRCEA ALEXANDRU MATEESCU, Université du Québec à Montréal; DIEGO MANTOVANI, Laval University.
Título: | Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery.
Ano de publicação: | 2022
Fonte/Imprenta: | Molecules, v. 27, n. 21, 7271, p. 1-19, 2022.
ISSN: | 1420-3049
DOI: | https://doi.org/10.3390/molecules27217271
Idioma: | Inglês
Conteúdo: | Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.
Palavras-Chave: | Agente bioativo; Antiaterosclerótica; Antiatherosclerotic activities; Antiinflammatory; Antioxidant activities; Antioxidantes; Antitumoral; Bioactive agent delivery; Carboxymethyl starch; Jamelão; Monolithic tablets.
Thesagro: | Antiinflamatório; Fruto.
Thesaurus Nal: | Anthocyanins; Fruit composition; Syzygium cumini.
Categoria do assunto: | S Ciências Biológicas
URL: | http://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1153621/1/CNAT-9.pdf
Registro original: | Embrapa Alimentos e Territórios (CNAT)
Exemplares: | CNAT - (5-1) - UPC - AP - DD -  -  -  - DIS