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Registro Completo |
Biblioteca(s): |
Embrapa Gado de Leite. |
Data corrente: |
30/10/2021 |
Data da última atualização: |
03/10/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
OLIVEIRA, E. R.; FAYER, L.; ZANETTE, R. S. S.; LADEIRA, L. O.; OLIVEIRA, L. F. C. de; MARANDUBA, C. M. C.; BRANDAO, H. de M.; MUNK, M. |
Afiliação: |
EDUARDA R. OLIVEIRA, Universidade Federal de Juiz de Fora; LEONARA FAYER, Universidade Federal de Juiz de Fora; RAFAELLA S. S. ZANETTE, Universidade Federal de Juiz de Fora; LUIZ O. LADEIRA, Universidade Federal de Minas Gerais; LUIZ F. C. DE OLIVEIRA, Universidade Federal de Juiz de Fora; CARLOS M. C. MARANDUBA, Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora. |
Título: |
Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Nanotechnology, v. 33, n. 6, 065101, 2022. |
DOI: |
https://doi.org/10.1088/1361-6528/ac335b |
Idioma: |
Inglês |
Conteúdo: |
Carboxylated Multi-wall Carbon Nanotube (MWCNT-COOH) presents unique properties due to nanoscale dimensions and permits a broad range of applications in different fields, such as bone tissue engineering and regenerative medicine. However, the cytocompatibility of MWCNT-COOH with human stem cells is poorly understood. Thus, studies elucidating how MWCNT-COOH affects human stem cell viability are essential to a safer application of nanotechnologies. Using stem cells from the human exfoliated deciduous teeth model, we have evaluated the effects of MWCNT-COOH on cell viability, oxidative cell stress, and DNA integrity. Results demonstrated that despite the decreased metabolism of mitochondria, MWCNT-COOH had no toxicity against stem cells. Cells maintained viability after MWCNT-COOH exposure. MWCNTCOOH did not alter the superoxide dismutase activity and did not cause genotoxic effects. The present findings are relevant to the potential application of MWCNT-COOH in the tissue engineering and regenerative medicine fields. |
Palavras-Chave: |
Células-tronco; Engenharia de tecido; Estudo in vitro; Nanotecnologia. |
Thesagro: |
Carbono. |
Categoria do assunto: |
G Melhoramento Genético |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1135728/1/Cytocompatibility-of-carboxylated-multi-wall-carbon-nanotubes-in-stem-cells-.pdf
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Marc: |
LEADER 01878naa a2200277 a 4500 001 2135728 005 2023-10-03 008 2022 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1088/1361-6528/ac335b$2DOI 100 1 $aOLIVEIRA, E. R. 245 $aCytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth.$h[electronic resource] 260 $c2022 520 $aCarboxylated Multi-wall Carbon Nanotube (MWCNT-COOH) presents unique properties due to nanoscale dimensions and permits a broad range of applications in different fields, such as bone tissue engineering and regenerative medicine. However, the cytocompatibility of MWCNT-COOH with human stem cells is poorly understood. Thus, studies elucidating how MWCNT-COOH affects human stem cell viability are essential to a safer application of nanotechnologies. Using stem cells from the human exfoliated deciduous teeth model, we have evaluated the effects of MWCNT-COOH on cell viability, oxidative cell stress, and DNA integrity. Results demonstrated that despite the decreased metabolism of mitochondria, MWCNT-COOH had no toxicity against stem cells. Cells maintained viability after MWCNT-COOH exposure. MWCNTCOOH did not alter the superoxide dismutase activity and did not cause genotoxic effects. The present findings are relevant to the potential application of MWCNT-COOH in the tissue engineering and regenerative medicine fields. 650 $aCarbono 653 $aCélulas-tronco 653 $aEngenharia de tecido 653 $aEstudo in vitro 653 $aNanotecnologia 700 1 $aFAYER, L. 700 1 $aZANETTE, R. S. S. 700 1 $aLADEIRA, L. O. 700 1 $aOLIVEIRA, L. F. C. de 700 1 $aMARANDUBA, C. M. C. 700 1 $aBRANDAO, H. de M. 700 1 $aMUNK, M. 773 $tNanotechnology$gv. 33, n. 6, 065101, 2022.
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Embrapa Gado de Leite (CNPGL) |
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1. | | GRATTAPAGLIA, D.; RESENDE, M. D. V. de; RESENDE, M. R.; SANSALONI, C. P.; PETROLI, C. D.; MISSIAGGIA, A. A.; TAKAHASHI, E. K.; ZAMPROGNO, K. C.; KILIAN, A. Genomic selection for growth traits in Eucalyptus: accuracy within and across breeding populations. In: IUFRO TREE BIOTECHNOLOGY CONFERENCE, 2011, Arraial d'Ajuda. From genomes do integration and delivery: extended abstracts proceedings. [S.l.]: Embrapa: Veracel: IUFRO, 2011.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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2. | | GRATTAPAGLIA, D.; RESENDE, M. D. V. de; RESENDE, M. R.; SANSALONI, C. P.; PETROLI, C. D.; MISSIAGGIA, A. A.; TAKAHASHI, E. K.; ZAMPROGNO, K. C.; KILIAN, A. Genomic selection for growth traits in Eucalyptus: accuracy within and across breeding populations. In: IUFRO TREE BIOTECHNOLOGY CONFERENCE, 2011, Arraial d'Ajuda. From genomes do integration and delivery: extended abstracts proceedings. [S.l.]: Embrapa: Veracel: IUFRO, 2011. 1 CD-ROMTipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Florestas. |
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3. | | SEDIYAMA, T.; SEDIYAMA, C. S.; REIS, M. S.; PEREIRA, M. G.; MARTINS, O.; DUTRA, J. H.; GOMES, J. L. L.; BHERING, M. C.; ARANTES, N. E.; SPEHAR, C. R.; OLIVEIRA, A. B.; RESENDE, M. R. "U.F.V.-5" novo cultivar de soja para o cerrado do Brasil Central. Vicosa: UFV, 1983. 6p. (UFV. Informe Tecnico, 31).Biblioteca(s): Embrapa Cerrados. |
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