Data/hora: 19/06/2024 10:59:27

Biblioteca(s): | Embrapa Caprinos e Ovinos.
Data corrente: | 04/04/2016
Data da última atualização: | 04/04/2016
Autoria: | RUFF, G. O.; FLURI, A.; LAZARY, S.; VOGT, H. R.; PETERHANS, E.; BERTONI, G.
Título: | The caprine major histocompatibility complex (MHC) and T cell receptor variable beta chain repertoire (TCRVbeta): components of specific immune response in resistance to infectious goat diseases.
Ano de publicação: | 2000
Fonte/Imprenta: | In: INTERNATIONAL CONFERENCE ON GOATS, 7., 2000, Tours, Poitiers, France. Proceedings... Paris: INRA: IGA: Institut de Elevage, 2000. v. 2, p. 714-715.
ISBN: | 2841480399
Idioma: | Inglês
Conteúdo: | The MHC is the interface where the effector cells of the adaptive immune systems meet the antigenic peptides of pathogens. The MHC is a highly polymorphic molecular complex which, differently for each individual, selects the peptides to be presented to the immune systems. This selective process determines the quality and intensity of the immune response. In this review we will present an overview of the progress achieved in characterizing the caprine MHC and its influence on the course of two infectious diseases of goats, i.e. caprine arthritis encephalitis and cowdriosis. Additionally, we will present data on the characterization ot he caprine T-cell receptor repertoire and experiments performed with MHC-monozygotic goats. The immune response of these animals to a well-defined synthetic peptide derived from the CAEV Gag protein shows the dramatic influence of the MHC on the T-cell response
Palavras-Chave: | Artrite Encefalite Caprina; CAEV; Caprine arthritis encephalit virus; Complexo principal de histocompatibilidade; Resposta imunológica.
Thesagro: | Caprino; Doença animal; Genética animal.
Thesaurus Nal: | Goats; Immune response; Major Histocompatibility complex.
Categoria do assunto: | G Melhoramento Genético
Registro original: | Embrapa Caprinos e Ovinos (CNPC)
Exemplares: | CNPC - (30629-1) - ADD - PL - PP - 636.39 - I61p - 2001.00421 - DIS