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Registro Completo |
Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
Data corrente: |
06/12/2019 |
Data da última atualização: |
10/12/2019 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
CÓCARO, E. S.; OLIVEIRA, J. S.; MENDES, N. P.; ALFENAS, R. C. G.; BENEVENUTO JÚNIOR, A. A.; DELIZA, R. |
Afiliação: |
Eliane S. Cócaro, UFRRJ; Julia Silva e Oliveira, UFV; Nelia P. Mendes, UFV; Rita C. G. Alfenas, UFV; Augusto Aloísio Benevuto Júnior, IFMG - Sudeste Minas Gerais Campus Rio Pomba; ROSIRES DELIZA, CTAA. |
Título: |
Sensory Characterization And The Effect Of Chicken Hamburger Added Of Functional Ingredient On The Food Intake Of Eutrophic Women. |
Ano de publicação: |
2019 |
Fonte/Imprenta: |
In: SIMPÓSIO LATINO AMERICANO DE CIÊNCIA DE ALIMENTOS , 13., 2019, Campinas. O futuro dos alimentos: Anais... Campinas: Galoá, 2019. 1 p. |
Idioma: |
Inglês |
Notas: |
Publicado no Anais Eletrônico da Galoá Proceddings. SLACA. De 10 A 12 nov. 2019. Ref. 114018. |
Thesagro: |
Tecnologia de Alimento. |
Thesaurus Nal: |
Food intake; Hamburgers; Sensory evaluation. |
Categoria do assunto: |
Q Alimentos e Nutrição Humana |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/206363/1/galoa-proceedings-SLACA-2019-114018.pdf
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Marc: |
LEADER 00892nam a2200217 a 4500 001 2116163 005 2019-12-10 008 2019 bl uuuu u00u1 u #d 100 1 $aCÓCARO, E. S. 245 $aSensory Characterization And The Effect Of Chicken Hamburger Added Of Functional Ingredient On The Food Intake Of Eutrophic Women.$h[electronic resource] 260 $aIn: SIMPÓSIO LATINO AMERICANO DE CIÊNCIA DE ALIMENTOS , 13., 2019, Campinas. O futuro dos alimentos: Anais... Campinas: Galoá, 2019. 1 p.$c2019 500 $aPublicado no Anais Eletrônico da Galoá Proceddings. SLACA. De 10 A 12 nov. 2019. Ref. 114018. 650 $aFood intake 650 $aHamburgers 650 $aSensory evaluation 650 $aTecnologia de Alimento 700 1 $aOLIVEIRA, J. S. 700 1 $aMENDES, N. P. 700 1 $aALFENAS, R. C. G. 700 1 $aBENEVENUTO JÚNIOR, A. A. 700 1 $aDELIZA, R.
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Registro original: |
Embrapa Agroindústria de Alimentos (CTAA) |
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Registro Completo
Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia; Embrapa Semiárido. |
Data corrente: |
19/02/2021 |
Data da última atualização: |
07/02/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
ARRAES, F. B. M.; MARTINS-DE-SA, D; VASQUEZ, D. D. N.; MELO, B. P.; FAHEEM, M.; MACEDO, L. L. P. de; MORGANTE, C. V.; BARBOSA, J. A. R. G.; TOGAWA, R. C.; MOREIRA, V. J. V.; DANCHIN, E. G. J.; SA, M. F. G. de. |
Afiliação: |
FABRICIO BARBOSA MONTEIRO ARRAES; DIOGO MARTINS-DE-SA; DANIEL D. NORIEGA VASQUEZ; BRUNO PAES MELO; MUHAMMAD FAHEEM; LEONARDO LIMA PEPINO DE MACEDO; CAROLINA VIANNA MORGANTE, CPATSA; JOÃO ALEXANDRE R. G. BARBOSA; ROBERTO COITI TOGAWA; VALDEIR JUNIO VAZ MOREIRA; ETIENNE G. J. DANCHIN; MARIA FATIMA GROSSI DE SA. |
Título: |
Dissecting protein domain variability in the core rna interference machinery of five insect orders. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
RNA Biology, v. 18, n. 11, p. 1653-1681, 2021. |
DOI: |
https://doi.org/10.1080/15476286.2020.1861816 |
Idioma: |
Inglês |
Conteúdo: |
RNA interference (RNAi)-mediated gene silencing can be used to control specific insect pest populations. Unfortunately, the variable efficiency in the knockdown levels of target genes has narrowed the applicability of this technology to a few species. Here, we examine the current state of knowledge regarding the miRNA (micro RNA) and siRNA (small interfering RNA) pathways in insects and investigate the structural variability at key protein domains of the RNAi machinery. Our goal was to correlate domain variability with mechanisms affecting the gene silencing efficiency. To this end, the protein domains of 168 insect species, encompassing the orders Coleoptera, Diptera, Hemiptera, Hymenoptera, and Lepidoptera, were analysed using our pipeline, which takes advantage of meticulous structure-based sequence alignments. We used phylogenetic inference and the evolutionary rate coefficient (K) to outline the variability across domain regions and surfaces. Our results show that four domains, namely dsrm, Helicase, PAZ and Ribonuclease III, are the main contributors of protein variability in the RNAi machinery across different insect orders. We discuss the potential roles of these domains in regulating RNAi-mediated gene silencing and the role of loop regions in fine-tuning RNAi efficiency. Additionally, we identified several order-specific singularities which indicate that lepidopterans have evolved differently from other insect orders, possibly due to constant coevolution with plants and viruses. In conclusion, our results highlight several variability hotspots that deserve further investigation in order to improve the application of RNAi technology in the control of insect pests. MenosRNA interference (RNAi)-mediated gene silencing can be used to control specific insect pest populations. Unfortunately, the variable efficiency in the knockdown levels of target genes has narrowed the applicability of this technology to a few species. Here, we examine the current state of knowledge regarding the miRNA (micro RNA) and siRNA (small interfering RNA) pathways in insects and investigate the structural variability at key protein domains of the RNAi machinery. Our goal was to correlate domain variability with mechanisms affecting the gene silencing efficiency. To this end, the protein domains of 168 insect species, encompassing the orders Coleoptera, Diptera, Hemiptera, Hymenoptera, and Lepidoptera, were analysed using our pipeline, which takes advantage of meticulous structure-based sequence alignments. We used phylogenetic inference and the evolutionary rate coefficient (K) to outline the variability across domain regions and surfaces. Our results show that four domains, namely dsrm, Helicase, PAZ and Ribonuclease III, are the main contributors of protein variability in the RNAi machinery across different insect orders. We discuss the potential roles of these domains in regulating RNAi-mediated gene silencing and the role of loop regions in fine-tuning RNAi efficiency. Additionally, we identified several order-specific singularities which indicate that lepidopterans have evolved differently from other insect orders, possibly due to constant coevolution with plant... Mostrar Tudo |
Palavras-Chave: |
Argonaute; DCR1; Dicer; Drosha; DsRBDs; Evolução da proteína; In silico analysis; Loquacious; Pasha; Protein evolution; R2D2; RIIID II; Sequência de proteínas inteira; Structure-function relationship. |
Thesagro: |
Controle Genético; Genoma; Inseto; Praga; Proteína. |
Thesaurus NAL: |
Insect control; Pest control; Protein structure; Proteins. |
Categoria do assunto: |
-- G Melhoramento Genético |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/230917/1/Dissecting-protein-domain-variability-2021.pdf
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Marc: |
LEADER 03184naa a2200541 a 4500 001 2130159 005 2022-02-07 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1080/15476286.2020.1861816$2DOI 100 1 $aARRAES, F. B. M. 245 $aDissecting protein domain variability in the core rna interference machinery of five insect orders.$h[electronic resource] 260 $c2021 520 $aRNA interference (RNAi)-mediated gene silencing can be used to control specific insect pest populations. Unfortunately, the variable efficiency in the knockdown levels of target genes has narrowed the applicability of this technology to a few species. Here, we examine the current state of knowledge regarding the miRNA (micro RNA) and siRNA (small interfering RNA) pathways in insects and investigate the structural variability at key protein domains of the RNAi machinery. Our goal was to correlate domain variability with mechanisms affecting the gene silencing efficiency. To this end, the protein domains of 168 insect species, encompassing the orders Coleoptera, Diptera, Hemiptera, Hymenoptera, and Lepidoptera, were analysed using our pipeline, which takes advantage of meticulous structure-based sequence alignments. We used phylogenetic inference and the evolutionary rate coefficient (K) to outline the variability across domain regions and surfaces. Our results show that four domains, namely dsrm, Helicase, PAZ and Ribonuclease III, are the main contributors of protein variability in the RNAi machinery across different insect orders. We discuss the potential roles of these domains in regulating RNAi-mediated gene silencing and the role of loop regions in fine-tuning RNAi efficiency. Additionally, we identified several order-specific singularities which indicate that lepidopterans have evolved differently from other insect orders, possibly due to constant coevolution with plants and viruses. In conclusion, our results highlight several variability hotspots that deserve further investigation in order to improve the application of RNAi technology in the control of insect pests. 650 $aInsect control 650 $aPest control 650 $aProtein structure 650 $aProteins 650 $aControle Genético 650 $aGenoma 650 $aInseto 650 $aPraga 650 $aProteína 653 $aArgonaute 653 $aDCR1 653 $aDicer 653 $aDrosha 653 $aDsRBDs 653 $aEvolução da proteína 653 $aIn silico analysis 653 $aLoquacious 653 $aPasha 653 $aProtein evolution 653 $aR2D2 653 $aRIIID II 653 $aSequência de proteínas inteira 653 $aStructure-function relationship 700 1 $aMARTINS-DE-SA, D 700 1 $aVASQUEZ, D. D. N. 700 1 $aMELO, B. P. 700 1 $aFAHEEM, M. 700 1 $aMACEDO, L. L. P. de 700 1 $aMORGANTE, C. V. 700 1 $aBARBOSA, J. A. R. G. 700 1 $aTOGAWA, R. C. 700 1 $aMOREIRA, V. J. V. 700 1 $aDANCHIN, E. G. J. 700 1 $aSA, M. F. G. de 773 $tRNA Biology$gv. 18, n. 11, p. 1653-1681, 2021.
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Embrapa Semiárido (CPATSA) |
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