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Registro Completo |
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
07/12/2021 |
Data da última atualização: |
07/12/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
PIZAURO, L. J. L.; ALMEIDA, C. C. DE; SILVA, S. R.; MACINNES, J. I.; KROPINSKI, A. M.; ZAFALON, L. F.; AVILA, F. A. DE; VARANI, A. DE M. |
Afiliação: |
LUCAS JOSÉ LUDUVERIO PIZAURO, UNESP; CAMILA CHIODA DE ALMEIDA, UNESP; SAURA RODRIGUES SILVA, UNESP; JANET I. MACINNES, UNIVERSITY OF GUELPH; ANDREW M. KROPINSKI, UNIVERSITY OF GUELPH; LUIZ FRANCISCO ZAFALON, CPPSE; FERNANDO ANTÔNIO DE AVILA, UNESP; ALESSANDRO DE MELLO VARANI, UNESP. |
Título: |
Genomic comparisons and phylogenetic analysis of mastitis-related staphylococci with a focus on adhesion, bioflm, and related regulatory genes. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Scientific Reports, v.11, 2021, 17392. |
Páginas: |
10 p. |
DOI: |
https://doi.org/10.1038/s41598-021-96842-2 |
Idioma: |
Inglês |
Conteúdo: |
Mastitis is a common and costly disease on dairy farms, commonly caused by Staphylococcus spp. though the various species are associated with different clinical outcomes. In the current study, we performed genomic analyses to determine the prevalence of adhesion, biofilm, and related regulatory genes in 478 staphylococcal species isolated from clinical and subclinical mastitis cases deposited in public databases. The most prevalent adhesin genes (ebpS, atl, pls, sasH and sasF) were found in both clinical and subclinical isolates. However, the ebpS gene was absent in subclinical isolates of Staphylococcus arlettae, S. succinus, S. sciuri, S. equorun, S. galinarum, and S. saprophyticus. In contrast, the coa, eap, emp, efb, and vWbp genes were present more frequently in clinical (vs. subclincal) mastitis isolates and were highly correlated with the presence of the biofim operon (icaABCD) and its transcriptional regulator, icaR. Co-phylogenetic analyses suggested that many of these adhesins, biofilm, and associated regulatory genes could have been horizontally disseminated between clinical and subclinical isolates. Our results further suggest that several adhesins, biofilm, and related regulatory genes, which have been overlooked in previous studies, may be of use for virulence profiling of mastitis-related Staphylococcus strains or as potential targets for vaccine development. |
Palavras-Chave: |
Biofim operon; IcaABCD; IcaR; Regulatory genes. |
Thesaurus Nal: |
Adhesins; Mastitis; Staphylococcus; Staphylococcus arlettae; Staphylococcus equorum; Staphylococcus gallinarum; Staphylococcus saprophyticus; Staphylococcus sciuri; Staphylococcus succinus; Vaccine development. |
Categoria do assunto: |
H Saúde e Patologia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/228590/1/GenomicComparisons.pdf
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Marc: |
LEADER 02607naa a2200397 a 4500 001 2137199 005 2021-12-07 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1038/s41598-021-96842-2$2DOI 100 1 $aPIZAURO, L. J. L. 245 $aGenomic comparisons and phylogenetic analysis of mastitis-related staphylococci with a focus on adhesion, bioflm, and related regulatory genes.$h[electronic resource] 260 $c2021 300 $a10 p. 520 $aMastitis is a common and costly disease on dairy farms, commonly caused by Staphylococcus spp. though the various species are associated with different clinical outcomes. In the current study, we performed genomic analyses to determine the prevalence of adhesion, biofilm, and related regulatory genes in 478 staphylococcal species isolated from clinical and subclinical mastitis cases deposited in public databases. The most prevalent adhesin genes (ebpS, atl, pls, sasH and sasF) were found in both clinical and subclinical isolates. However, the ebpS gene was absent in subclinical isolates of Staphylococcus arlettae, S. succinus, S. sciuri, S. equorun, S. galinarum, and S. saprophyticus. In contrast, the coa, eap, emp, efb, and vWbp genes were present more frequently in clinical (vs. subclincal) mastitis isolates and were highly correlated with the presence of the biofim operon (icaABCD) and its transcriptional regulator, icaR. Co-phylogenetic analyses suggested that many of these adhesins, biofilm, and associated regulatory genes could have been horizontally disseminated between clinical and subclinical isolates. Our results further suggest that several adhesins, biofilm, and related regulatory genes, which have been overlooked in previous studies, may be of use for virulence profiling of mastitis-related Staphylococcus strains or as potential targets for vaccine development. 650 $aAdhesins 650 $aMastitis 650 $aStaphylococcus 650 $aStaphylococcus arlettae 650 $aStaphylococcus equorum 650 $aStaphylococcus gallinarum 650 $aStaphylococcus saprophyticus 650 $aStaphylococcus sciuri 650 $aStaphylococcus succinus 650 $aVaccine development 653 $aBiofim operon 653 $aIcaABCD 653 $aIcaR 653 $aRegulatory genes 700 1 $aALMEIDA, C. C. DE 700 1 $aSILVA, S. R. 700 1 $aMACINNES, J. I. 700 1 $aKROPINSKI, A. M. 700 1 $aZAFALON, L. F. 700 1 $aAVILA, F. A. DE 700 1 $aVARANI, A. DE M. 773 $tScientific Reports$gv.11, 2021, 17392.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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Registro Completo
Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
Data corrente: |
13/12/2018 |
Data da última atualização: |
23/06/2022 |
Tipo da produção científica: |
Artigo em Anais de Congresso |
Autoria: |
CAMPOS, G. S.; REIMANN, F. A.; JUNQUEIRA, V. S.; BRACCINI, J.; CARDOSO, L. L.; YOKOO, M. J. I.; SOLLERO, B. P.; GULIAS GOMES, C. C.; BOLIGON, A. A.; CAETANO, A. R.; CARDOSO, F. F. |
Afiliação: |
G. S. Campos, UFPEL; F. A. Reimann, UFPEL; V. S. Junqueira, UFV; J. Braccini, UFRGS; L. L. Cardoso, UFPEL; MARCOS JUN ITI YOKOO, CPPSUL; BRUNA PENA SOLLERO, CPPSUL; CLAUDIA CRISTINA GULIAS GOMES, CPPSUL; A. A. Boligon, UFPEL; ALEXANDRE RODRIGUES CAETANO, Cenargen; FERNANDO FLORES CARDOSO, CPPSUL. |
Título: |
Tag-SNP selection using Bayesian genome-wide association study for growth and adaptation traits in Hereford and Braford cattle. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University, 2018. |
Idioma: |
Inglês |
Conteúdo: |
The aim of this study was to perform a Bayesian genome-wide association study (GWAS) to identify genomic regions associated with growth and adaptation traits in Hereford and Braford cattle, and to select Tag-SNPs to represent these regions in low-density panels useful for genomic predictions. |
Palavras-Chave: |
Predição. |
Thesagro: |
Gado de Corte; Melhoramento Genético Animal. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/188089/1/tag-snp-selection-using-bayesian-genome-wide-association-study-growth-and-adaptation-traits-hereford.pdf
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Marc: |
LEADER 01201nam a2200265 a 4500 001 2101423 005 2022-06-23 008 2018 bl uuuu u01u1 u #d 100 1 $aCAMPOS, G. S. 245 $aTag-SNP selection using Bayesian genome-wide association study for growth and adaptation traits in Hereford and Braford cattle.$h[electronic resource] 260 $aIn: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 11., 2018, Auckland, New Zealand. Proceedings... Massey University$c2018 520 $aThe aim of this study was to perform a Bayesian genome-wide association study (GWAS) to identify genomic regions associated with growth and adaptation traits in Hereford and Braford cattle, and to select Tag-SNPs to represent these regions in low-density panels useful for genomic predictions. 650 $aGado de Corte 650 $aMelhoramento Genético Animal 653 $aPredição 700 1 $aREIMANN, F. A. 700 1 $aJUNQUEIRA, V. S. 700 1 $aBRACCINI, J. 700 1 $aCARDOSO, L. L. 700 1 $aYOKOO, M. J. I. 700 1 $aSOLLERO, B. P. 700 1 $aGULIAS GOMES, C. C. 700 1 $aBOLIGON, A. A. 700 1 $aCAETANO, A. R. 700 1 $aCARDOSO, F. F.
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Embrapa Recursos Genéticos e Biotecnologia (CENARGEN) |
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