Data/hora: 26/05/2024 20:55:06

Biblioteca(s): 	Embrapa Unidades Centrais.	
Data corrente: 	19/09/2017	
Data da última atualização: 	29/12/2017	
Autoria: 	PEIXOTO, P. V.; OLIVEIRA, K. D.; FRANÇA, T. N.; DRIEMEIER, D.; DUARTE, M. D.; BEZERRA JUNIOR, P. S.; CERQUEIRA, V. D.; ARMIÉN, A. G.	
Afiliação: 	Paulo V. Peixoto, Departamento de Nutrição Animal e Pastagem/Instituto de Zootecnia/Universidade Federal Rural do Rio de Janeiro - UFRRJ; Krishna D. Oliveira, Programa de Pós-Graduação em Medicina Veterinária/Instituto de Veterinária - IV/UFRRJ; Ticiana N. França, Departamento de Epidemiologia e Saúde Pública - DESP/IV-UFRRJ; David Driemeier, Departamento de Patologia e Clínica Veterinária/Faculdade de Medicina Veterinária/Universidade Federal do Rio Grande do Sul - UFRGS; Marcos D. Duarte, Instituto de Medicina Veterinária/Universidade Federal do Pará - UFPA; Pedro S. Bezerra Jr, Instituto de Medicina Veterinária/Universidade Federal do Pará - UFPA; Valíria D. Cerqueira, Instituto de Medicina Veterinária/Universidade Federal do Pará - UFPA; Aníbal G. Armién, Minnesota Veterinary Diagnostic Laboratory/Department of Veterinary Population/College of Veterinary Medicine/University of Minnesota.	
Título: 	Experimental and iatrogenic poisoning by sodium selenite in pigs.	
Ano de publicação: 	2017	
Fonte/Imprenta: 	Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 6, p. 561-569, jun. 2017.	
Idioma: 	Português	
Notas: 	Título em inglês: Intoxicação iatrogênica e experimental por selenito de sódio em suínos.	
Conteúdo: 	Following a case of iatrogenic selenium poisoning in a young pig, an experimental study was carry out. Sodium selenite was orally and parenterally administered to 13 pigs that were subdivided into three groups (G1, G2 and G3). The animals in groups G1 and G3 received sodium selenite intramuscularly (IM), G1 received a comercial formula, and G3 received sodium selenite mixed with distilled water at different dosages, and those in group G2 were fed commercial sodium selenite. Acute and subacute poisoning was observed in both groups, although the onset of clinical signs was slower in group G2. Only one pig (in group G1) that had received the highest dose showed a peracute course. Apathy, anorexia, dyspnea, vomiting, muscular tremors, proprioceptive deficit, ataxia and paresis of the hind limbs progressing to the front limbs evolving to tetraplegia were observed. Postmortem findings differed whether the animals received the injected (G1 and G3) or oral (G2) sodium selenite. The liver was moderately atrophic in some animals of G2. Some of the animals in groups G1 and G3 presented with lung edema. One pig in G3 had yellowish-brown areas in the ventral horns of the cervical intumescences of the spinal cord. The most important histological changes were present in the ventral horns of the cervical and lumbar intumescences of the spinal cord. In one animal, changes were present in the brainstem and mesencephalon. The initial lesion was a perivascular and astrocyte edema that progressing to lysis and death of astrocytes and neurons. In the chronic stage of the lesions, there were extensive areas of liquefaction necrosis with perivascular lymphocytic and histiocytic infiltration and occasional eosinophils. It seems that disruption of the blood-brain barrier due to astrocyte edema is the most likely mechanism of CNS lesion.	
Palavras-Chave: 	Focal symmetrical poliomyelomalacia; Patogênese; Selenium poisoning.	
Thesagro: 	Suíno.	
Thesaurus Nal: 	Pathogenesis; Sodium selenite; Swine.	
Categoria do assunto: 	--	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/item/163973/1/Experimental-and-iatrogenic.pdf	
Registro original: 	Embrapa Unidades Centrais (AI-SEDE)	
Exemplares: 	AI-SEDE - (61730-1) - UPE - AP - DD -  -  -  - DIS