Data/hora: 07/06/2024 08:43:58

Biblioteca(s): 	Embrapa Pecuária Sudeste.	
Data corrente: 	07/07/2021	
Data da última atualização: 	28/09/2021	
Autoria: 	ROSA, L. K.; COSTA, F. S.; HAUAGGE, C. M.; MOBILE, R. Z.; LIMA, A. A. S. de; AMARAL, C. D. B. do; MACHADO, R. C.; NOGUEIRA, A. R. de A.; BRANCHER, J. A.; ARAUJO, M. R. DE.	
Afiliação: 	LETÍCIA KREUTZ ROSA, UFPR; FLORIATAN SANTOS COSTA, UFPR; CECÍLIA MORAES HAUAGGE, UFPR; RAFAEL ZANCAN MOBILE, UFPR; ANTONIO ADILSON SOARES DE LIMA, UFPR; CLARICE DIAS BRITTO DO AMARAL, UFPR; RAQUEL CARDOSO MACHADO, UFSCAR; ANA RITA DE ARAUJO NOGUEIRA, CPPSE; JOÃO ARMANDO BRANCHER, PUC-PR; MELISSA RODRIGUES DE ARAUJO, UFPR.	
Título: 	Oral health, organic and inorganic saliva composition of men with Schizophrenia: case-control study.	
Ano de publicação: 	2021	
Fonte/Imprenta: 	Journal of Trace Elements in Medicine and Biology, v.66, jul. 2021, 126743.	
Páginas: 	8 p.	
ISSN: 	0946-672X	
DOI: 	https://doi.org/10.1016/j.jtemb.2021.126743	
Idioma: 	Inglês	
Conteúdo: 	Background: Schizophrenia (SCZ) presents complex challenges related to diagnosis and clinical monitoring. The study of conditions associated with SCZ can be facilitated by using potential markers and patterns that provide information to support the diagnosis and oral health. Methods: The salivary composition of patients diagnosed with SCZ (n = 50) was evaluated and compared to the control (n = 50). Saliva samples from male patients were collected and clinical parameters were evaluated. The concentration of total proteins and amylase were determined and salivary macro- and microelements were quantified by ICP OES and ICP-MS. Exploratory data analysis based on artificial intelligence tools was used in the investigation. Results: There was a significant increase in the salivary concentrations of Al, Fe, Li, Mg, Na, and V, higher prevalence of caries (p < 0.001), periodontal disease (p < 0.001), and reduced salivary flow rate (p = 0.019) in SCZ patients. Also, samples were grouped into six clusters. As, Co, Cr, Cu, Mn, Mo, Ni, Se, and Sr were correlated with each other, while Fe, K, Li, Ti, and V showed the highest concentrations in the samples distributed in the clusters with the highest association between SZC patients and controls. Conclusions: The results obtained indicate changes in salivary flow, organic composition, and levels of macro- and microelements in SCZ patients. Salivary concentrations of Fe, Mg, and Na may be related to oral conditions, higher prevalence of caries, and periodontal disease. The exploratory analysis showed different patterns in the salivary composition of SCZ patients impacted by associations between oral health conditions and the use of medications. Future studies are encouraged to confirm the results investigated in this study.	
Palavras-Chave: 	Exploratory data analysis; Self-organizing map.	
Thesagro: 	Saliva.	
Thesaurus Nal: 	Schizophrenia; Trace elements.	
Categoria do assunto: 	S Ciências Biológicas	
Registro original: 	Embrapa Pecuária Sudeste (CPPSE)	
Exemplares: 	CPPSE - (25361-1) - UPC - AP - DD - PROCI-2021.00092 - ROS - 2021.00100 - DIS