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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
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Data corrente: |
10/10/2011 |
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Data da última atualização: |
10/10/2011 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
RODRIGUES, I. A.; ALVIANO, D. S.; GOMES, M. T.; SILVA, D. O.; ANTONIASSI, R.; SILVA, A. J. R.; BIZZO, H. R.; ALVIANO, C. S.; VERMELHO, A. B.; ROSA, M. do S. S. |
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Afiliação: |
IGOR A. RODRIGUES, UFRJ; DANIELA S. ALVIANO, UFRJ; MARTA T. GOMES, UFRJ; DAVI O. SILVA, UFRJ; ROSEMAR ANTONIASSI, CTAA; ANTONIO JORGE R. SILVA, UFRJ; HUMBERTO RIBEIRO BIZZO, CTAA; CELUTA S. ALVIANO, UFRJ; ALANE B. VERMELHO, UFRJ; MARIA DO SOCORRO S. ROSA, UFRJ. |
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Título: |
In vitro anti-Leishmania amazonensis activity of the polymeric procyanidin-rich aqueous extract from Syagrus coronata. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Journal of Medicinal Plants Research, v. 5, n. 16, p. 3781-3790, Aug. 2011. |
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Idioma: |
Inglês |
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Conteúdo: |
Leishmania amazonensis is one of the major etiological agents of diffuse cutaneous leishmaniasis, which is frequently unresponsive to all known treatments. Syagrus coronata (Arecaceae) is a palm tree with industrial applications used in local medicine by the Brazilian ?caatinga? communities. This work evaluates the in vitro leishmanicidal activity of S. coronata on L. amazonensis. Promastigote forms of L. amazonensis were treated with different concentrations of the aqueous extract from S. coronata. In addition, we evaluated the effect of the aqueous extract on infection of mouse peritoneal macrophages and nitric oxide production. The minimal inhibitory concentration (MIC) of the aqueous extract of S. coronata was 8.3 µg/ml. Morphological changes in L. amazonensis promastigotes treated with 50 µg/ml of the aqueous extract were observed by light microscopy. Pretreatment of mouse peritoneal macrophages with 33 µg/ml of S. coronata aqueous extract reduced the association index between macrophages and L. amazonensis by 70.4%, with a concomitant increase of 158.3% in nitric oxide production by the infected macrophages. In addition, the aqueous extract exhibited no cytotoxic effect on mammalian cells and elicited no allergic reactions in vivo, indicating good prospects for the development of new drugs of herbal origins to treat leishmaniasis. |
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Thesagro: |
Syagrus Coronata. |
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Thesaurus Nal: |
Arecaceae; Leishmania; Leishmania amazonensis; Nitric oxide; Syagrus. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/43040/1/2011-052.pdf
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Marc: |
LEADER 02237naa a2200301 a 4500
001 1902781
005 2011-10-10
008 2011 bl uuuu u00u1 u #d
100 1 $aRODRIGUES, I. A.
245 $aIn vitro anti-Leishmania amazonensis activity of the polymeric procyanidin-rich aqueous extract from Syagrus coronata.
260 $c2011
520 $aLeishmania amazonensis is one of the major etiological agents of diffuse cutaneous leishmaniasis, which is frequently unresponsive to all known treatments. Syagrus coronata (Arecaceae) is a palm tree with industrial applications used in local medicine by the Brazilian ?caatinga? communities. This work evaluates the in vitro leishmanicidal activity of S. coronata on L. amazonensis. Promastigote forms of L. amazonensis were treated with different concentrations of the aqueous extract from S. coronata. In addition, we evaluated the effect of the aqueous extract on infection of mouse peritoneal macrophages and nitric oxide production. The minimal inhibitory concentration (MIC) of the aqueous extract of S. coronata was 8.3 µg/ml. Morphological changes in L. amazonensis promastigotes treated with 50 µg/ml of the aqueous extract were observed by light microscopy. Pretreatment of mouse peritoneal macrophages with 33 µg/ml of S. coronata aqueous extract reduced the association index between macrophages and L. amazonensis by 70.4%, with a concomitant increase of 158.3% in nitric oxide production by the infected macrophages. In addition, the aqueous extract exhibited no cytotoxic effect on mammalian cells and elicited no allergic reactions in vivo, indicating good prospects for the development of new drugs of herbal origins to treat leishmaniasis.
650 $aArecaceae
650 $aLeishmania
650 $aLeishmania amazonensis
650 $aNitric oxide
650 $aSyagrus
650 $aSyagrus Coronata
700 1 $aALVIANO, D. S.
700 1 $aGOMES, M. T.
700 1 $aSILVA, D. O.
700 1 $aANTONIASSI, R.
700 1 $aSILVA, A. J. R.
700 1 $aBIZZO, H. R.
700 1 $aALVIANO, C. S.
700 1 $aVERMELHO, A. B.
700 1 $aROSA, M. do S. S.
773 $tJournal of Medicinal Plants Research$gv. 5, n. 16, p. 3781-3790, Aug. 2011.
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Embrapa Agroindústria de Alimentos (CTAA) |
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