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Registro Completo |
Biblioteca(s): |
Embrapa Instrumentação. |
Data corrente: |
30/03/2022 |
Data da última atualização: |
30/03/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
SANTOS, D. M. dos; ANNUNZIO, S. R. de; CARMELLO, J. C.; PAVARINA, A. C.; FONTANA, C. R.; CORREA, D. S. |
Afiliação: |
DANIEL SOUZA CORREA, CNPDIA. |
Título: |
Combining coaxial electrospinning and 3D printing: design of biodegradable bilayered membranes with dual drug delivery capability for periodontitis treatment. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
ACS Applied Bio Materials, v. 5, 2022. |
Páginas: |
146−159 |
DOI: |
https://doi.org/10.1021/acsabm.1c01019 |
Idioma: |
Português |
Conteúdo: |
Periodontitis is a chronic inflammatory disease that can lead to significant destruction of tooth-supporting tissues, compromising dental function and patient?s health. Although the currently employed treatment approaches can limit the advance of the disease, the development of multifunctional and hierarchically structured materials is still in demand for achieving successful tissue regeneration. Here, we combine coaxial electrospinning and 3D printing techniques to prepare bilayered zein-based membranes as a potential dual drug delivery platform for periodontal tissue regeneration. A layer of core−sheath electrospun nanofibers consisting of poly(ethylene oxide) (PEO)/curcumin (Curc)/ tetracycline hydrochloride (TH) as the core and zein/poly(ε-caprolactone)(PCL)/β-glycerolphosphate (β-GP) as the sheath was deposited over a 3D printed honeycomb PLA/zein/Curc platform in order to render a bilayered structure that can mimic the architecture of periodontal tissue. The physicochemical properties of engineered constructs as well as the release profiles of distinct drugs were mainly controlled by varying the concentration of zein (10, 20, 30%, w/w relative to dry PCL) on the sheath layer of nanofibers, which displayed average diameters ranging from 150 to 400 nm. In vitro experiments demonstrated that the bilayered constructs provided sustained release of distinct drugs over 8 days and exhibited biocompatibility toward human oral keratinocytes (Nok-si) (cell viability >80%) as well as antibacterial activity against distinct bacterial strains including those of the red complex such as Porphyromonas gingivalis and Treponema denticola, which are recognized to elicit aggressive and chronic periodontitis. Our study reveals the potential of zein-based bilayered membranes as a dual drug delivery platform for periodontal tissue regeneration. MenosPeriodontitis is a chronic inflammatory disease that can lead to significant destruction of tooth-supporting tissues, compromising dental function and patient?s health. Although the currently employed treatment approaches can limit the advance of the disease, the development of multifunctional and hierarchically structured materials is still in demand for achieving successful tissue regeneration. Here, we combine coaxial electrospinning and 3D printing techniques to prepare bilayered zein-based membranes as a potential dual drug delivery platform for periodontal tissue regeneration. A layer of core−sheath electrospun nanofibers consisting of poly(ethylene oxide) (PEO)/curcumin (Curc)/ tetracycline hydrochloride (TH) as the core and zein/poly(ε-caprolactone)(PCL)/β-glycerolphosphate (β-GP) as the sheath was deposited over a 3D printed honeycomb PLA/zein/Curc platform in order to render a bilayered structure that can mimic the architecture of periodontal tissue. The physicochemical properties of engineered constructs as well as the release profiles of distinct drugs were mainly controlled by varying the concentration of zein (10, 20, 30%, w/w relative to dry PCL) on the sheath layer of nanofibers, which displayed average diameters ranging from 150 to 400 nm. In vitro experiments demonstrated that the bilayered constructs provided sustained release of distinct drugs over 8 days and exhibited biocompatibility toward human oral keratinocytes (Nok-si) (cell vi... Mostrar Tudo |
Palavras-Chave: |
Asymmetric membrane; Controlled release; Electrospinning; Hierarchical materials; Periodontal membrane. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02757naa a2200265 a 4500 001 2141634 005 2022-03-30 008 2022 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1021/acsabm.1c01019$2DOI 100 1 $aSANTOS, D. M. dos 245 $aCombining coaxial electrospinning and 3D printing$bdesign of biodegradable bilayered membranes with dual drug delivery capability for periodontitis treatment.$h[electronic resource] 260 $c2022 300 $a146−159 520 $aPeriodontitis is a chronic inflammatory disease that can lead to significant destruction of tooth-supporting tissues, compromising dental function and patient?s health. Although the currently employed treatment approaches can limit the advance of the disease, the development of multifunctional and hierarchically structured materials is still in demand for achieving successful tissue regeneration. Here, we combine coaxial electrospinning and 3D printing techniques to prepare bilayered zein-based membranes as a potential dual drug delivery platform for periodontal tissue regeneration. A layer of core−sheath electrospun nanofibers consisting of poly(ethylene oxide) (PEO)/curcumin (Curc)/ tetracycline hydrochloride (TH) as the core and zein/poly(ε-caprolactone)(PCL)/β-glycerolphosphate (β-GP) as the sheath was deposited over a 3D printed honeycomb PLA/zein/Curc platform in order to render a bilayered structure that can mimic the architecture of periodontal tissue. The physicochemical properties of engineered constructs as well as the release profiles of distinct drugs were mainly controlled by varying the concentration of zein (10, 20, 30%, w/w relative to dry PCL) on the sheath layer of nanofibers, which displayed average diameters ranging from 150 to 400 nm. In vitro experiments demonstrated that the bilayered constructs provided sustained release of distinct drugs over 8 days and exhibited biocompatibility toward human oral keratinocytes (Nok-si) (cell viability >80%) as well as antibacterial activity against distinct bacterial strains including those of the red complex such as Porphyromonas gingivalis and Treponema denticola, which are recognized to elicit aggressive and chronic periodontitis. Our study reveals the potential of zein-based bilayered membranes as a dual drug delivery platform for periodontal tissue regeneration. 653 $aAsymmetric membrane 653 $aControlled release 653 $aElectrospinning 653 $aHierarchical materials 653 $aPeriodontal membrane 700 1 $aANNUNZIO, S. R. de 700 1 $aCARMELLO, J. C. 700 1 $aPAVARINA, A. C. 700 1 $aFONTANA, C. R. 700 1 $aCORREA, D. S. 773 $tACS Applied Bio Materials$gv. 5, 2022.
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3. | | SANTOS, D. M.; CHAGAS, P. A. M.; LEITE, I. S.; INADA, N. M.; ANNUNZIO, S. R.; FONTANA, C. R.; CAMPANA-FILHO, S. P.; CORREA, D. S. Core-sheath nanostructured chitosan-based nonwovens as a potential drug delivery system for periodontitis treatment. International Journal of Biological Macromolecules, n.142 , 2020. 521 - 534Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
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