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| Registros recuperados : 17 | |
| 8. |  | ALVES FILHO, J. G.; ALVES, F. S. F.; PINHEIRO, R. R.; FONSECA, A. A. da; ARAGÃO, M. A. do C. Onfaloflebite e artrite em caprinos causada por Corynebacterium pseudotuberculosis: relato de caso. In: ENCONTRO DE INICIAÇÃO CIENTÍFICA, 5.; ENCONTRO DE PÓS GRADUAÇÃO E PESQUISA, 2., 2003, Sobral. Anais... Sobral: Universidade Estadual Vale do Acaraú, 2003. p. 139| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 9. | | ARAGÃO, M. A. do C.; PINHEIRO, R. R.; ALVES, F. S. F.; FONSECA, A. A. da; ALVES FILHO, J. G. Corynebacterium pseudotuberculosis isolado de abscesso na base do cérebro: relato de caso. In: ENCONTRO DE INICIAÇÃO CIENTÍFICA, 5.; ENCONTRO DE PÓS-GRADUAÇÃO E PESQUISA, 2., 2003, Sobral. Anais... Sobral: Universidade Estadual Vale do Acaraú, 2003. p. 118.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 12. | | LOPES, T. A.; COSTA, J. N.; RIBEIRO, R. P.; PASSOS, J. R. S.; SOARES, M. A. A.; ALVES FILHO, J. G.; CUNHA, E. V.; HURK, R. van den; ANDRIOLI, A.; SILVA, J. R. V. Influence of caprine arthritis encephalitis on expression ofovulation related genes and activation of primordial folliclescultured in presence of phytohemagglutinin, epidermalgrowth factor or bothT. Small Ruminant Research, Amsterdam, v. 123, n. 2/3, p. 278-286, Feb. 2015.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 13. | | SOARES, F. S.; AMARAL, F. C.; SILVA, N. L. S.; VALENTE, M. R.; SANTOS, L. K. R.; YAMASHIRO, L. H.; SCHEFFE, M. S.; CASTANHEIRA, F. V. E. S.; FERREIRA, R. G.; GEHRKE, L.; ALVES-FILHO, J. C.; SILVA, L. P.; BÁFICA, A.; SPILLER, F. Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis. Frontiers in Immunology, v. 8, 2017. Article 1890.| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 14. | | MOREIRA, R. F.; MATOS, M. N. C.; ALVES FILHO, J. G.; VALLE, R. V. do; ELOY, A. M. X.; PINTO, T. M. F.; MACHADO, S. P.; COSTA, C. R. R.; LIMA FILHO, J. L. de; LIMA, J. P. M. S.; CUNHA, R. M. S. da. Diversity of ejaculated sperm proteins in Moxotó bucks (Capra hircus) evaluated by multiple extraction methods. Animal Reproduction, Belo Horizonte, v. 15, n. 1, p. 84-92, jan./mar. 2018.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 15. | | PINTO, T. M. F.; MOREIRA, R. F.; MATOS, M. N. C.; SOARES, V. V. M.; AGUIAR, M. V. de A.; ARAGÃO, P. de T. T. D. de; ALVES FILHO, J. G.; MORENO, F. B. M. B.; MONTEIRO-MOREIRA, A. C. de O.; COSTA, C. R. R.; LIMA FILHO, J. L. de; ELOY, A. M. X.; CUNHA, R. M. S. da. Evaluation of the proteomic profiles of ejaculated spermatozoa from Saanen bucks (Capra hircus). Animal Reproduction, v. 16, n. 4, p. 902-913, 2019.| Biblioteca(s): Embrapa Caprinos e Ovinos. |
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| 16. | | BREGANTE, E. M.; SÁ, C. O. A. de; CARRIJO, N. A.; MARTINS, R. de S. F.; ARAÚJO, J. M. de; ROCHA FILHO, J. da; DOMINGUES, H. V.; CALAZANS, V. A.; DIAS, I. S.; BOTELHO, S. S.; BERNARDES, C. L.; ALVES FILHO, J. de S.; COSTA, A. M. A. da. Primeiros resultados da implantação do projeto desempenho do trator de pneus Valmet 138.4-Turbo e seus implementos. Brasília, DF: IICA/PROVÁRZEAS, 1985. 57 p. (IICA/PROVÁRZEAS. Informação Técnica. Documento, 3).| Biblioteca(s): Embrapa Meio Norte / UEP-Parnaíba. |
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| 17. | | BREGANTE, E. M.; SÁ, C. O. A. de; CARRIJO, N. A.; MARTINS, R. de S. F.; ARAÚJO, J. M. de; ROCHA FILHO, J. da; DOMINGUES, H. V.; CALAZANS, V. A.; DIAS, I. S.; BOTELHO, S. S.; BERNARDES, C. L.; ALVES FILHO, J. de S.; COSTA, A. M. A. da; NASCIMENTO, A. L. C. de L. Primeiros resultados da implantação do projeto trabalhos de engenharia rural. Brasília, DF: IICA/PROVÁRZEAS, 1986. 63 p. (IICA/PROVÁRZEAS.Informação Técnica. Documentos, 5).| Biblioteca(s): Embrapa Meio Norte / UEP-Parnaíba. |
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| Registros recuperados : 17 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Agricultura Digital. |
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Data corrente: |
21/11/2012 |
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Data da última atualização: |
14/04/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
B - 5 |
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Autoria: |
D'AFONSECA, V.; SOARES, S. C.; ALI, A.; SANTOS, A. R.; PINTO, A. C.; MAGALHÃES, A. A. C.; FARIA, C. de J.; BARBOSA, E.; GUIMARÃES, L. C.; ESLABÃO, M.; ALMEIDA, S. S.; ABREU, V. A. C.; ZERLOTINI, A.; CARNEIRO, A. R.; CERDEIRA, L. T.; RAMOS, R. T. J.; HIRATA JÚNIOR, R.; MATTOS-GUARALDI, A. L.; TROST, E.; TAUCH, A.; SILVA, A.; SCHNEIDER, M. P.; MIYOSHI, A.; AZEVEDO, V. |
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Afiliação: |
VÍVIAN D’AFONSECA, UFMG; SIOMAR C. SOARES, UFMG; AMJAD ALI, UFMG; ANDERSON R. SANTOS, UFMG; ANNE C. PINTO, UFMG; ARYANE A. C. MAGALHÃES, UFMG; CÁSSIO DE JESUS FARIA, UFMG; EUDES BARBOSA, UFMG; LUIS C. GUIMARÃES, UFMG; MARCUS ESLABÃO, UFPel; SINTIA S. ALMEIDA, UFMG; VINICIUS A. C. ABREU, UFMG; ADHEMAR ZERLOTINI NETO, CNPTIA; ADRIANA R. CARNEIRO, UFPA; LOUISE T. CERDEIRA, UFPA; ROMMEL T. J. RAMOS, UFPA; RAPHAEL HIRATA JÚNIOR, UERJ; ANA L. MATTOS-GUARALDI, UERJ; EVA TROST, Bielefeld University; ANDREAS TAUCH, Bielefeld University; ARTUR SILVA, UFPA; MARIA P. SCHNEIDER, UFPA; ANDERSON MIYOSHI, UFMG; VASCO AZEVEDO, UFMG. |
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Título: |
Reannotation of the Corynebacterium diphtheriae NCTC13129 genome as a new approach to studying gene targets connected to virulence and pathogenicity in diphtheria. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Open Access Bioinformatics, v. 4, p. 1-13, 2012. |
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Idioma: |
Inglês |
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Conteúdo: |
Background: The reannotation of genomes already on file is a new approach to discovering new genetic elements and to make the genomes more descriptive and current with relevant features regarding the organism?s lifestyle. Within this approach, the present study aimed to reannotate the genome of the Gram-positive human pathogen Corynebacterium diphtheriae, which causes diphtheria. The deposit of massive amounts of information linked to other species of the genus Corynebacterium has facilitated the updating of the genomic interpretation of this microorganism. Additionally, the emergence of invasive disease by nontoxigenic strains of C. diphtheriae and the reemergence of diphtheria in partially immunized populations have given impetus to new studies in relation to its structural and functional genome. Results: In relation to structural genomics, 23 coding regions (coding sequences) were deleted and 71 new genes were added to the genome annotation. Nevertheless, all the pseudogenes were validated and ten new pseudogenes were created. In relation to functional genomics, about 57% of the genome annotation was updated and became functionally more informative. The product descriptions of 41% (973 proteins) were updated. Among them, 370 that were previously annotated as ?hypothetical proteins,? now have more informative descriptions. With the new annotation, the plasticity of the genome became evident, which shows improvements in the annotation of 13 pathogenicity islands already described in the literature. In addition, the large number of transposases and the presence of structural genes of bacteriophages make their genomic versatility evident. Contrasting with this reality, it also allowed the clarification of some aspects concerned with mechanisms used by C. diphtheriae to stop the invasion of the genome by bacteriophages, mediated by the clustered regularly interspaced short palindromic repeats region. Conclusion: The reannotation of the C. diphtheriae genome provided an improvement in annotation of the C. diphtheriae genome in several aspects, such as virulence characteristics and plasticity events. Moreover, the protocol used here can be extended to various other pathogens in order to improve the genomic information already on file in public databases and to minimize propagating errors. The reannotated archive and updated archive are available at: http://lgcm.icb.ufmg.br/pub/C_diphtheriae_reannotation.embl. MenosBackground: The reannotation of genomes already on file is a new approach to discovering new genetic elements and to make the genomes more descriptive and current with relevant features regarding the organism?s lifestyle. Within this approach, the present study aimed to reannotate the genome of the Gram-positive human pathogen Corynebacterium diphtheriae, which causes diphtheria. The deposit of massive amounts of information linked to other species of the genus Corynebacterium has facilitated the updating of the genomic interpretation of this microorganism. Additionally, the emergence of invasive disease by nontoxigenic strains of C. diphtheriae and the reemergence of diphtheria in partially immunized populations have given impetus to new studies in relation to its structural and functional genome. Results: In relation to structural genomics, 23 coding regions (coding sequences) were deleted and 71 new genes were added to the genome annotation. Nevertheless, all the pseudogenes were validated and ten new pseudogenes were created. In relation to functional genomics, about 57% of the genome annotation was updated and became functionally more informative. The product descriptions of 41% (973 proteins) were updated. Among them, 370 that were previously annotated as ?hypothetical proteins,? now have more informative descriptions. With the new annotation, the plasticity of the genome became evident, which shows improvements in the annotation of 13 pathogenicity islands already des... Mostrar Tudo |
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Palavras-Chave: |
Bioinformática. |
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Thesagro: |
Genoma; Patogenicidade. |
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Thesaurus NAL: |
Bioinformatics; Corynebacterium diphtheriae; Genome; Pathogenicity islands. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/70533/1/OAB-25500-re-annotation-of-the-corynebacterium-diphtheriae-nctc13129-g-022412.pdf
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Marc: |
LEADER 03832naa a2200481 a 4500
001 1940203
005 2020-04-14
008 2012 bl uuuu u00u1 u #d
100 1 $aD'AFONSECA, V.
245 $aReannotation of the Corynebacterium diphtheriae NCTC13129 genome as a new approach to studying gene targets connected to virulence and pathogenicity in diphtheria.$h[electronic resource]
260 $c2012
520 $aBackground: The reannotation of genomes already on file is a new approach to discovering new genetic elements and to make the genomes more descriptive and current with relevant features regarding the organism?s lifestyle. Within this approach, the present study aimed to reannotate the genome of the Gram-positive human pathogen Corynebacterium diphtheriae, which causes diphtheria. The deposit of massive amounts of information linked to other species of the genus Corynebacterium has facilitated the updating of the genomic interpretation of this microorganism. Additionally, the emergence of invasive disease by nontoxigenic strains of C. diphtheriae and the reemergence of diphtheria in partially immunized populations have given impetus to new studies in relation to its structural and functional genome. Results: In relation to structural genomics, 23 coding regions (coding sequences) were deleted and 71 new genes were added to the genome annotation. Nevertheless, all the pseudogenes were validated and ten new pseudogenes were created. In relation to functional genomics, about 57% of the genome annotation was updated and became functionally more informative. The product descriptions of 41% (973 proteins) were updated. Among them, 370 that were previously annotated as ?hypothetical proteins,? now have more informative descriptions. With the new annotation, the plasticity of the genome became evident, which shows improvements in the annotation of 13 pathogenicity islands already described in the literature. In addition, the large number of transposases and the presence of structural genes of bacteriophages make their genomic versatility evident. Contrasting with this reality, it also allowed the clarification of some aspects concerned with mechanisms used by C. diphtheriae to stop the invasion of the genome by bacteriophages, mediated by the clustered regularly interspaced short palindromic repeats region. Conclusion: The reannotation of the C. diphtheriae genome provided an improvement in annotation of the C. diphtheriae genome in several aspects, such as virulence characteristics and plasticity events. Moreover, the protocol used here can be extended to various other pathogens in order to improve the genomic information already on file in public databases and to minimize propagating errors. The reannotated archive and updated archive are available at: http://lgcm.icb.ufmg.br/pub/C_diphtheriae_reannotation.embl.
650 $aBioinformatics
650 $aCorynebacterium diphtheriae
650 $aGenome
650 $aPathogenicity islands
650 $aGenoma
650 $aPatogenicidade
653 $aBioinformática
700 1 $aSOARES, S. C.
700 1 $aALI, A.
700 1 $aSANTOS, A. R.
700 1 $aPINTO, A. C.
700 1 $aMAGALHÃES, A. A. C.
700 1 $aFARIA, C. de J.
700 1 $aBARBOSA, E.
700 1 $aGUIMARÃES, L. C.
700 1 $aESLABÃO, M.
700 1 $aALMEIDA, S. S.
700 1 $aABREU, V. A. C.
700 1 $aZERLOTINI, A.
700 1 $aCARNEIRO, A. R.
700 1 $aCERDEIRA, L. T.
700 1 $aRAMOS, R. T. J.
700 1 $aHIRATA JÚNIOR, R.
700 1 $aMATTOS-GUARALDI, A. L.
700 1 $aTROST, E.
700 1 $aTAUCH, A.
700 1 $aSILVA, A.
700 1 $aSCHNEIDER, M. P.
700 1 $aMIYOSHI, A.
700 1 $aAZEVEDO, V.
773 $tOpen Access Bioinformatics$gv. 4, p. 1-13, 2012.
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Embrapa Agricultura Digital (CNPTIA) |
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