Data/hora: 21/06/2024 15:36:57

Biblioteca(s): 	Embrapa Gado de Leite.	
Data corrente: 	20/04/2010	
Data da última atualização: 	16/02/2024	
Autoria: 	ALVES, C. C. de S.; AZEVEDO, A. L. S.; RODRIGUES, M. F.; MACHADO, R. P.; SOUZA, M. A.; MACHADO, M. A.; TEIXEIRA, H. C.; FERREIRA, A. P.	
Afiliação: 	CAIO CÉSAR DE SOUZA ALVES, UFJF; ANA LUISA SOUSA AZEVEDO, CNPGL; MICHELE F. RODRIGUES, UFJF; RACHEL P. MACHADO, UFJF; SUPREMA; MARIA A. SOUZA, UFJF; MARCO ANTONIO MACHADO, CNPGL; HENRIQUE C. TEIXEIRA, UFJF; ANA P. FERREIRA, UFJF.	
Título: 	Cellular and humoral immune responses during intrathoracic paracoccidioidomycosis in BALB/c mice.	
Ano de publicação: 	2009	
Fonte/Imprenta: 	Comparative Immunology, Microbiology and Infectious Discases, v. 32, n. 6, p. 513-525, 2009.	
DOI: 	https://doi.org/10.1016/j.cimid.2008.07.006	
Idioma: 	Inglês	
Conteúdo: 	Paracoccidioidomycosis is a chronic infection that primarily affects the lungs. Here we investigated cellular and humoral immune responses after intrathoracic Paracoccidioidesbrasiliensis infection in BALB/c mice. P. brasiliensis-colony-forming units (CFUs), fungal DNA and granulomas in lungs increased progressively, peaking at day 90 postinfection (p.i.). IFN-γ production was highest on day 15 p.i., declining thereafter. The kinetics of the NO production was similar to that described for IFN-γ. In contrast, IL-10 increased from day 45 p.i. reaching a peak at day 90. Levels of serum IgG1 were higher than IgG2a between days 30 and 90 p.i. 30% of mice died by day 90 p.i. These data indicate that infection with P. brasiliensis by the intrathoracic route shows high IFN-γ and NO production at day 15 p.i., unable to control multiplication of fungi, which appears to be associated with a progressive increase in IL-10 and in the number and complexity of granulomas.	
Palavras-Chave: 	Antibody response; IFN-y; IL-10; Intrathoracic route.	
Thesaurus Nal: 	Paracoccidioides brasiliensis.	
Categoria do assunto: 	H Saúde e Patologia	
URL: 	http://ainfo.cnptia.embrapa.br/digital/bitstream/doc/697051/1/Cellular-and-humoral-immune-responses-during-intrathoracic-paracoccidioidomycosis.pdf	
Registro original: 	Embrapa Gado de Leite (CNPGL)	
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