Data/hora: 24/09/2024 09:09:48

Biblioteca(s): 	Embrapa Pecuária Sudeste.	
Data corrente: 	02/12/2020	
Data da última atualização: 	02/12/2020	
Autoria: 	DINIZ, W. J. da S.; BANERJEE, P.; MAZZONI, G.; COUTINHO, L. L.; CESAR, A. S. M.; AFONSO, J.; GROMBONI, C. F.; NOGUEIRA, A. R. de A.; KADARMIDEEN, H. N.; REGITANO, L. C. de A.	
Afiliação: 	Wellison Jarles da Silva Diniz, UFSCAR; Priyanka Banerjee, Technical University of Denmark; Gianluca Mazzoni, Technical University of Denmark; Luiz Lehmann Coutinho, USP, ESALq; Aline Silva Mello Cesar, USP, ESALq; Juliana Afonso, UFSCAR; Caio Fernando Gromboni, IFBA; ANA RITA DE ARAUJO NOGUEIRA, CPPSE; Haja N. Kadarmideen, Technical University of Denmark; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.	
Título: 	Interplay among miR-29 family, mineral metabolism, and gene regulation in Bos indicus muscle.	
Ano de publicação: 	2020	
Fonte/Imprenta: 	Molecular Genetics and Genomics, v. 295, p. 1113-1127, may. 2020.	
DOI: 	https://doi.org/10.1007/s00438-020-01683-9	
Idioma: 	Inglês	
Conteúdo: 	An interplay between gene expression, mineral concentration, and beef quality traits in Bos indicus muscle has been reported previously under a network approach. However, growing evidence suggested that miRNAs not only modulate gene expression but are also involved with mineral homeostasis. To our knowledge, understanding of the miRNA?gene expression-mineral concentration relationship in mammals is still minimal. Therefore, we carried out a miRNA co-expression and multi-level miRNA?mRNA integration analyses to predict the putative drivers (miRNAs and genes) associated with muscle mineral concentration in Nelore steers. In this study, we identified calcium and iron to be the pivotal minerals associated with miRNAs and gene targets. Furthermore, we identified the miR-29 family (miR-29a, -29b, -29c, -29d-3p, and -29e) as the putative key regulators modulating mineral homeostasis. The miR-29 family targets genes involved with AMPK, insulin, mTOR, and thyroid hormone signaling pathways. Finally, we reported an interplay between miRNAs and minerals acting cooperatively to modulate co-expressed genes and signaling pathways both involved with mineral and energy homeostasis in Nelore muscle. Although we provided some evidence to understand this complex relationship, future work should determine the functional implications of minerals for miRNA levels and their feedback regulation system.	
Palavras-Chave: 	Co expression; Mineral homeostasis; Regulatory network; Systems biology.	
Thesaurus Nal: 	Calcium; Iron.	
Categoria do assunto: 	G Melhoramento Genético	
Registro original: 	Embrapa Pecuária Sudeste (CPPSE)	
Exemplares: 	CPPSE - (25176-1) - UPC - AP - DD - PROCI-2020.00090 - DIN - 2020.00141 - DIS