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Registro Completo |
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
08/04/2016 |
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Data da última atualização: |
29/12/2017 |
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Autoria: |
SOARES, M. P.; PAVARINI, S. P.; BARROS, S. S.; ADRIEN, M. L.; QUEVEDO, P. S.; SCHILD, A. L.; DRIEMEIER, D. |
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Afiliação: |
MAURO P. SOARES, UFPEL; SAULO P. PAVARINI, UFRGS; SEVERO S. BARROS, UFPEL; MARIA L. ADRIEN, Universidad de la República - Uruguai; PEDRO S. QUEVEDO, UFSM; ANA L. SCHILD, UFPEL; DAVID DRIEMEIER, UFRGS. |
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Título: |
Ultrastructural lesions in the myocardium and kidneys of rabbits in experimental acute Amorimia exotropica poisoning. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 3, p. 161-166, mar. 2016. |
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Idioma: |
Inglês |
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Conteúdo: |
Amorimia exotropica is an important plant associated with sudden death in cattle in Southern Brazil. In order to understand the mechanisms by which A. exotropica causes acute lesions in the heart and kidney of intoxicated animals, an experiment was conducted to determine the histopathology and ultrastructure of myocardial and renal lesions of intoxicated rabbits. After receiving 18g/kg of dried plant, six rabbits died suddenly. At necropsy, the liver was swollen and no other macroscopic lesions were observed. Histologically, centrolobular and midzonal hepatocytes were vacuolated. These vacuoles were strong PAS stained positive, suggesting that they corresponded to glycogen accumulations. In some regions of the ventricular septum and ventricles were found vacuoles of different sizes and the kidneys of two rabbits showed vacuolar degeneration on distal convoluted tubules. Ultrastructurally, the myocardium had cardiomyocytes swelling with separation of myofibrils bundles and rupture and disorganization of the sarcomeres. The mitochondria displayed swelling, disorganization, disruption of the mitochondrial cristae, and electron-dense matrix. Some mitochondria exhibited eccentric projections of their membranes with disruption of both outer and inner embranes. The sarcoplasmic reticulum had no alterations, whereas the T-tubule system was occasionally dilated and ruptured. The kidneys had mitochondrial swelling with disorganization and disruption of the mitochondrial cristae. The vacuoles result from the swelling of the endoplasmatic reticulum and usually were located between two basolateral infoldings and mitochondria, occurring preferentially around the nucleus. The myocytes and T system damages induced by A. exotropica result in acute heart failure and death. Furthermore, this mechanism of cardiotoxicity may be common to all plant containing monofluoroacetate. MenosAmorimia exotropica is an important plant associated with sudden death in cattle in Southern Brazil. In order to understand the mechanisms by which A. exotropica causes acute lesions in the heart and kidney of intoxicated animals, an experiment was conducted to determine the histopathology and ultrastructure of myocardial and renal lesions of intoxicated rabbits. After receiving 18g/kg of dried plant, six rabbits died suddenly. At necropsy, the liver was swollen and no other macroscopic lesions were observed. Histologically, centrolobular and midzonal hepatocytes were vacuolated. These vacuoles were strong PAS stained positive, suggesting that they corresponded to glycogen accumulations. In some regions of the ventricular septum and ventricles were found vacuoles of different sizes and the kidneys of two rabbits showed vacuolar degeneration on distal convoluted tubules. Ultrastructurally, the myocardium had cardiomyocytes swelling with separation of myofibrils bundles and rupture and disorganization of the sarcomeres. The mitochondria displayed swelling, disorganization, disruption of the mitochondrial cristae, and electron-dense matrix. Some mitochondria exhibited eccentric projections of their membranes with disruption of both outer and inner embranes. The sarcoplasmic reticulum had no alterations, whereas the T-tubule system was occasionally dilated and ruptured. The kidneys had mitochondrial swelling with disorganization and disruption of the mitochondrial cristae. The v... Mostrar Tudo |
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Palavras-Chave: |
Amorimia exotropica; Cardiotoxicity; Monofluoroacetate; Sudden death. |
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Thesagro: |
Morte súbita; Planta tóxica; Rim. |
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Thesaurus Nal: |
Kidneys; plant poisoning; Poisonous plants; Ultrastructure. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/142183/1/Ultrastructural-lesions.pdf
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Marc: |
LEADER 02828naa a2200325 a 4500
001 2042945
005 2017-12-29
008 2016 bl uuuu u00u1 u #d
100 1 $aSOARES, M. P.
245 $aUltrastructural lesions in the myocardium and kidneys of rabbits in experimental acute Amorimia exotropica poisoning.
260 $c2016
520 $aAmorimia exotropica is an important plant associated with sudden death in cattle in Southern Brazil. In order to understand the mechanisms by which A. exotropica causes acute lesions in the heart and kidney of intoxicated animals, an experiment was conducted to determine the histopathology and ultrastructure of myocardial and renal lesions of intoxicated rabbits. After receiving 18g/kg of dried plant, six rabbits died suddenly. At necropsy, the liver was swollen and no other macroscopic lesions were observed. Histologically, centrolobular and midzonal hepatocytes were vacuolated. These vacuoles were strong PAS stained positive, suggesting that they corresponded to glycogen accumulations. In some regions of the ventricular septum and ventricles were found vacuoles of different sizes and the kidneys of two rabbits showed vacuolar degeneration on distal convoluted tubules. Ultrastructurally, the myocardium had cardiomyocytes swelling with separation of myofibrils bundles and rupture and disorganization of the sarcomeres. The mitochondria displayed swelling, disorganization, disruption of the mitochondrial cristae, and electron-dense matrix. Some mitochondria exhibited eccentric projections of their membranes with disruption of both outer and inner embranes. The sarcoplasmic reticulum had no alterations, whereas the T-tubule system was occasionally dilated and ruptured. The kidneys had mitochondrial swelling with disorganization and disruption of the mitochondrial cristae. The vacuoles result from the swelling of the endoplasmatic reticulum and usually were located between two basolateral infoldings and mitochondria, occurring preferentially around the nucleus. The myocytes and T system damages induced by A. exotropica result in acute heart failure and death. Furthermore, this mechanism of cardiotoxicity may be common to all plant containing monofluoroacetate.
650 $aKidneys
650 $aplant poisoning
650 $aPoisonous plants
650 $aUltrastructure
650 $aMorte súbita
650 $aPlanta tóxica
650 $aRim
653 $aAmorimia exotropica
653 $aCardiotoxicity
653 $aMonofluoroacetate
653 $aSudden death
700 1 $aPAVARINI, S. P.
700 1 $aBARROS, S. S.
700 1 $aADRIEN, M. L.
700 1 $aQUEVEDO, P. S.
700 1 $aSCHILD, A. L.
700 1 $aDRIEMEIER, D.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 36, n. 3, p. 161-166, mar. 2016.
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| 1. |  | SOARES, M. P.; PAVARINI, S. P.; BARROS, S. S.; ADRIEN, M. L.; QUEVEDO, P. S.; SCHILD, A. L.; DRIEMEIER, D. Ultrastructural lesions in the myocardium and kidneys of rabbits in experimental acute Amorimia exotropica poisoning. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 3, p. 161-166, mar. 2016.| Biblioteca(s): Embrapa Unidades Centrais. |
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