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| 1. |  | UZAL, F. A.; SAPUTO, J.; SAYEED, S.; VIDAL, J. E.; FISHER, D. J.; POON, R.; ADAMS, V.; FERNANDEZ-MIYAKAWA, M. E.; ROOD, J. I.; MCCLANE, B. A. Development and application of new mouse models to study the pathogenesis of Clostridium perfringens type C Enterotoxemias. Infection and Immunity, v. 77, n. 12, p. 5291-5299, 2009.| Biblioteca(s): Embrapa Semiárido. |
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Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
28/11/2019 |
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Data da última atualização: |
28/11/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
CLEMENTE, Z.; SILVA, G. H. da; NUNES, M. C. S.; MARTINEZ, D. S. T.; MAURER-MORELLI, C. V.; THOMAZ, A. A.; CASTRO, V. L. S. S. de. |
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Afiliação: |
ZAIRA CLEMENTE, LNNano-CNPEM; GABRIELA HELENA DA SILVA, CENA-USP; MIRIAM CELI DE SOUZA NUNES, FCM-UNICAMP; DIEGO STEFANI TEODORO MARTINEZ, CENA-USP; CLAUDIA VIANA MAURER-MORELLI, FCM-UNICAMP; ANDRE ALEXANDRE THOMAZ, FCM-UNICAMP; VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA. |
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Título: |
Exploring the mechanisms of graphene oxide behavioral and morphological changes in zebrafish. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Environmental Science and Pollution Research, v. 26, n. 29, p. 30508-30523, 2019. |
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DOI: |
https://doi.org/10.1007/s11356-019-05870-z |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The presence of natural organic matter such as humic acid (HA) can influence the behavior of graphene oxide (GO) in the aquatic environment. In this study, zebrafish embryos were analyzed after 5 and 7 days of exposure to GO (100 mg L-1) and HA (20 mg L?1) alone or together. The results indicated that, regardless of the presence of HA, larvae exposed to GO for 5 days showed an increase in locomotor activity, reduction in the yolk sac size, and total length and inhibition of AChE activity, but there was no difference in enzyme expression. The statistical analysis indicated that the reductions in total larval length, yolk sac size, and AChE activity in larvae exposed to GO persisted in relation to the control group, but there was a recovery of these parameters in groups also exposed to HA. Larvae exposed to GO for 7 days did not show significant differences in locomotor activity, but the RT-PCR gene expression analysis evidenced an increase in the AChE expression. Since the embryos exposed to GO showed a reduction in overall length, they were submitted to confocal microscopy and their muscle tissue configuration investigated. No changes were observed in the muscle tissue. The results indicated that HA is associated with the toxicity risk modulation by GO and that some compensatory homeostasis mechanisms may be involved in the developmental effects observed in zebrafish. |
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Palavras-Chave: |
Óxido de grafeno. |
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Thesagro: |
Composto Químico; Matéria Orgânica; Peixe de Água Doce; Toxidez. |
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Thesaurus NAL: |
Aquatic environment; Behavior change; Biomarkers; Danio rerio; Ecotoxicology; Environmental impact; Graphene oxide; Humic acids; Toxicity. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/205788/1/Castro-Explorin-Graphene-2019.pdf
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Marc: |
LEADER 02527naa a2200373 a 4500
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008 2019 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s11356-019-05870-z$2DOI
100 1 $aCLEMENTE, Z.
245 $aExploring the mechanisms of graphene oxide behavioral and morphological changes in zebrafish.$h[electronic resource]
260 $c2019
520 $aAbstract: The presence of natural organic matter such as humic acid (HA) can influence the behavior of graphene oxide (GO) in the aquatic environment. In this study, zebrafish embryos were analyzed after 5 and 7 days of exposure to GO (100 mg L-1) and HA (20 mg L?1) alone or together. The results indicated that, regardless of the presence of HA, larvae exposed to GO for 5 days showed an increase in locomotor activity, reduction in the yolk sac size, and total length and inhibition of AChE activity, but there was no difference in enzyme expression. The statistical analysis indicated that the reductions in total larval length, yolk sac size, and AChE activity in larvae exposed to GO persisted in relation to the control group, but there was a recovery of these parameters in groups also exposed to HA. Larvae exposed to GO for 7 days did not show significant differences in locomotor activity, but the RT-PCR gene expression analysis evidenced an increase in the AChE expression. Since the embryos exposed to GO showed a reduction in overall length, they were submitted to confocal microscopy and their muscle tissue configuration investigated. No changes were observed in the muscle tissue. The results indicated that HA is associated with the toxicity risk modulation by GO and that some compensatory homeostasis mechanisms may be involved in the developmental effects observed in zebrafish.
650 $aAquatic environment
650 $aBehavior change
650 $aBiomarkers
650 $aDanio rerio
650 $aEcotoxicology
650 $aEnvironmental impact
650 $aGraphene oxide
650 $aHumic acids
650 $aToxicity
650 $aComposto Químico
650 $aMatéria Orgânica
650 $aPeixe de Água Doce
650 $aToxidez
653 $aÓxido de grafeno
700 1 $aSILVA, G. H. da
700 1 $aNUNES, M. C. S.
700 1 $aMARTINEZ, D. S. T.
700 1 $aMAURER-MORELLI, C. V.
700 1 $aTHOMAZ, A. A.
700 1 $aCASTRO, V. L. S. S. de
773 $tEnvironmental Science and Pollution Research$gv. 26, n. 29, p. 30508-30523, 2019.
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Embrapa Meio Ambiente (CNPMA) |
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