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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
12/06/2023 |
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Autoria: |
REW, R. S. |
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Título: |
Mode of action of common anthelmintics. |
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Ano de publicação: |
1978 |
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Fonte/Imprenta: |
Journal of Veterinary Pharmacology and Therapeutics, v. 1, n. 3, p. 183-198, Sep. 1978. |
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DOI: |
https://doi.org/10.1111/j.1365-2885.1978.tb00326.x |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The primary physiological mode of action of nearly all drugs used to control helminth parasites is not well understood. Examination of the general modes of action in terms of parasite requirements for survival may, however, provide guidelines to continue our present investigations and direct us for future research. Two general areas of drug activity are (1) interference with energy-generating metabolism, and (2) interference with proper neuromuscular coordination. Few exceptions are found to these areas because the target organisms require little else for survival. The target of most previously effective and many presently effective anthelmintics is an adult parasite. Adult helminth parasites must maintain an advantageous feeding site and must transport and metabolize substrates (primarily glucose) to generate life-maintaining energy. Adult worms have almost no other short-term requirements for survival because they have little or no metabolic activity in either lipid synthesis or oxidation, nucleic acid synthesis, or protein synthesis (except egg-laying). Examination of specifics of energy-generating metabolism and putative neurochemical transmitters allows us certain predictions in relating a given drug activity to an individual species. These examinations indicate that such diversity exists among helminth metabolic or nervous systems that a broad-spectrum anthelmintic would most likely inhibit at several sensitive points. Published information on drug action and differences in data interpretation are discussed. Two novel areas for future anthelmintic investigations may be (1) juvenile hormone or ecdysone analogs, and (2) pheromones. A combined empirical and rational approach to the development of new drugs may be the most efficient avenue of future research. MenosAbstract: The primary physiological mode of action of nearly all drugs used to control helminth parasites is not well understood. Examination of the general modes of action in terms of parasite requirements for survival may, however, provide guidelines to continue our present investigations and direct us for future research. Two general areas of drug activity are (1) interference with energy-generating metabolism, and (2) interference with proper neuromuscular coordination. Few exceptions are found to these areas because the target organisms require little else for survival. The target of most previously effective and many presently effective anthelmintics is an adult parasite. Adult helminth parasites must maintain an advantageous feeding site and must transport and metabolize substrates (primarily glucose) to generate life-maintaining energy. Adult worms have almost no other short-term requirements for survival because they have little or no metabolic activity in either lipid synthesis or oxidation, nucleic acid synthesis, or protein synthesis (except egg-laying). Examination of specifics of energy-generating metabolism and putative neurochemical transmitters allows us certain predictions in relating a given drug activity to an individual species. These examinations indicate that such diversity exists among helminth metabolic or nervous systems that a broad-spectrum anthelmintic would most likely inhibit at several sensitive points. Published information on drug action and... Mostrar Tudo |
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Palavras-Chave: |
Controle; Nematodeo. |
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Thesagro: |
Mamífero; Parasitologia. |
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Thesaurus Nal: |
Animal parasitic nematodes; Anthelmintics; Chemical control; Drug resistance; Helminths. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02514naa a2200241 a 4500
001 1520944
005 2023-06-12
008 1978 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1111/j.1365-2885.1978.tb00326.x$2DOI
100 1 $aREW, R. S.
245 $aMode of action of common anthelmintics.$h[electronic resource]
260 $c1978
520 $aAbstract: The primary physiological mode of action of nearly all drugs used to control helminth parasites is not well understood. Examination of the general modes of action in terms of parasite requirements for survival may, however, provide guidelines to continue our present investigations and direct us for future research. Two general areas of drug activity are (1) interference with energy-generating metabolism, and (2) interference with proper neuromuscular coordination. Few exceptions are found to these areas because the target organisms require little else for survival. The target of most previously effective and many presently effective anthelmintics is an adult parasite. Adult helminth parasites must maintain an advantageous feeding site and must transport and metabolize substrates (primarily glucose) to generate life-maintaining energy. Adult worms have almost no other short-term requirements for survival because they have little or no metabolic activity in either lipid synthesis or oxidation, nucleic acid synthesis, or protein synthesis (except egg-laying). Examination of specifics of energy-generating metabolism and putative neurochemical transmitters allows us certain predictions in relating a given drug activity to an individual species. These examinations indicate that such diversity exists among helminth metabolic or nervous systems that a broad-spectrum anthelmintic would most likely inhibit at several sensitive points. Published information on drug action and differences in data interpretation are discussed. Two novel areas for future anthelmintic investigations may be (1) juvenile hormone or ecdysone analogs, and (2) pheromones. A combined empirical and rational approach to the development of new drugs may be the most efficient avenue of future research.
650 $aAnimal parasitic nematodes
650 $aAnthelmintics
650 $aChemical control
650 $aDrug resistance
650 $aHelminths
650 $aMamífero
650 $aParasitologia
653 $aControle
653 $aNematodeo
773 $tJournal of Veterinary Pharmacology and Therapeutics$gv. 1, n. 3, p. 183-198, Sep. 1978.
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| 1. |  | FARIAS, F. J. C.; SILVA FILHO, J. L. da; FREIRE, E. C.; RODRIGUES, S. M. M.; LIRA, A. J. da S.; CAVALCANTE. M. G. R.; SOLETTI, F. Comportamento de linhagens avançadas de algodoeiro herbáceo nas condições do cerrado safra 06-07. In: CONGRESSO BRASILEIRO DO ALGODÃO, 7., 2009, Foz do Iguaçu. Sustentabilidade da cotonicultura brasileira e expansão dos mercados: anais. Campina Grande: Embrapa Algodão, 2009. 1 CD-ROM| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Algodão. |
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| 2. | | FARIAS, F. J. C.; FREIRE, E. C.; SILVA FILHO, J. L.; MORELLO, C. de L.; LIRA, A. J. da S.; MENEZES, V. L.; CAVALCANTE, M. G. R. Comportamento de linhagens precoces de algodoeiro herbáceo no cerrado de Mato Grosso. Safra 2006/07. In: CONGRESSO BRASILEIRO DO ALGODÃO, 7., 2009, Foz do Iguaçu. Sustentabilidade da cotonicultura brasileira e expansão dos mercados: anais. Campina Grande: Embrapa Algodão, 2009. 1 CD-ROM| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Algodão. |
| |
| 3. | | FARIAS, F. J. C.; SILVA FILHO, J. L.; FREIRE, E. C.; GALBIERI, R.; LIRA, A. J. da S.; CAVALCANTE, M. G. R. Desempenho de cultivares e linhagens elites de algodoeiro nas condições do Cerrado de Mato Grosso - safra 2006-07. In: CONGRESSO BRASILEIRO DO ALGODÃO, 7., 2009, Foz do Iguaçu. Sustentabilidade da cotonicultura brasileira e expansão dos mercados: anais. Campina Grande: Embrapa Algodão, 2009. 1 CD-ROM| Tipo: Artigo em Anais de Congresso / Nota Técnica |
| Biblioteca(s): Embrapa Algodão. |
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| Registros recuperados : 3 | |
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