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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical. |
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Data corrente: |
17/07/2025 |
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Data da última atualização: |
17/07/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FROTA, L. S.; BARBOSA, S. I. C. G.; FEITOSA, C. C.; LOPES, F. F. DA S.; OLIVEIRA, D. P. DE; FREITAS, L. S.; MATTOS, A. L. A.; SILVA, W. M. B. DA; ISHIKI, H. M.; MORAES, S. M. DE. |
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Afiliação: |
LUCAS SOARES FROTA, STATE UNIVERSITY OF CEARÁ; SARA INGRID CAETANO GOMES BARBOSA, STATE UNIVERSITY OF CEARÁ; CAMILA COSTA FEITOSA, STATE UNIVERSITY OF CEARÁ; FRANCISCO FLÁVIO DA SILVA LOPES, STATE UNIVERSITY OF CEARÁ; DANIEL PEREIRA DE OLIVEIRA, STATE UNIVERSITY OF CEARÁ; LEONARDO SOARES FREITAS, STATE UNIVERSITY OF CEARÁ; ADRIANO LINCOLN ALBUQUERQUE MATTOS, CNPAT; WILDSON MAX BARBOSA DA SILVA, STATE UNIVERSITY VALE DO ACARAÚ; HAMILTON MITSUGU ISHIKI, STATE UNIVERSITY OF CEARÁ; SELENE MAIA DE MORAES, STATE UNIVERSITY OF CEARÁ. |
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Título: |
Chemical Characterization, Antioxidant, and Anticholinesterase Activities of Libidibia ferrea (Mart. Ex Tul.) L.P.Queiroz and In Silico Studies with the Acetylcholinesterase Enzyme. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Chemistry & Biodiversity, 0:e00550, 2025. |
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DOI: |
https://doi.org/10.1002/cbdv.202500550 |
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Idioma: |
Inglês |
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Conteúdo: |
Libidibia ferrea is used in many parts of Brazil for a variety of conditions, such as inflammation, respiratory disorders, muscle pain, and gastrointestinal problems. This study evaluated the chemistry and antioxidant and acetylcholinesterase (AChE) inhibitory activities of L. ferrea extracts. Hydroethanolic extracts of leaves (ELLF) and bark (EBLF) were obtained by maceration, while a methanolic fraction of seeds (MFLF) was prepared by Soxhlet extraction and essential oil of flowers (EOLF) extracted by hydrodistillation. Antioxidant activity was evaluated by scavenging 2,2-diphenyl-1-picrylhydrazyl and 2,2’- azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radicals, and AChE inhibition using the Ellman method. The ELLF, EBLF, and MFLF were characterized by high-performance liquid chromatography showing the presence of gallic acid, chlorogenic acid, catechin, caffeic acid, rutin, and ellagic acid. EOLF and MFLF showed high tannin content and exhibited antioxidant and AChE inhibitory effects similar to standards. Molecular docking revealed that (Z)-9-tetradecenyl acetate, the major compound of EOLF identified by gas chromatography/mass spectrometry, interacts with AChE at the same site as galantamine. These findings suggest that L. ferrea has promising therapeutic potential for treating acetylcholine-related diseases such as Alzheimer’s. |
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Palavras-Chave: |
Acetilcolinesterase; Espectroscopia; Libidibia ferrea. |
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Thesagro: |
Antioxidante; Óleo Essencial. |
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Thesaurus Nal: |
Acetylcholinesterase; Antioxidants; Essential oils; Spectroscopy. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02478naa a2200349 a 4500
001 2177382
005 2025-07-17
008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1002/cbdv.202500550$2DOI
100 1 $aFROTA, L. S.
245 $aChemical Characterization, Antioxidant, and Anticholinesterase Activities of Libidibia ferrea (Mart. Ex Tul.) L.P.Queiroz and In Silico Studies with the Acetylcholinesterase Enzyme.$h[electronic resource]
260 $c2025
520 $aLibidibia ferrea is used in many parts of Brazil for a variety of conditions, such as inflammation, respiratory disorders, muscle pain, and gastrointestinal problems. This study evaluated the chemistry and antioxidant and acetylcholinesterase (AChE) inhibitory activities of L. ferrea extracts. Hydroethanolic extracts of leaves (ELLF) and bark (EBLF) were obtained by maceration, while a methanolic fraction of seeds (MFLF) was prepared by Soxhlet extraction and essential oil of flowers (EOLF) extracted by hydrodistillation. Antioxidant activity was evaluated by scavenging 2,2-diphenyl-1-picrylhydrazyl and 2,2’- azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radicals, and AChE inhibition using the Ellman method. The ELLF, EBLF, and MFLF were characterized by high-performance liquid chromatography showing the presence of gallic acid, chlorogenic acid, catechin, caffeic acid, rutin, and ellagic acid. EOLF and MFLF showed high tannin content and exhibited antioxidant and AChE inhibitory effects similar to standards. Molecular docking revealed that (Z)-9-tetradecenyl acetate, the major compound of EOLF identified by gas chromatography/mass spectrometry, interacts with AChE at the same site as galantamine. These findings suggest that L. ferrea has promising therapeutic potential for treating acetylcholine-related diseases such as Alzheimer’s.
650 $aAcetylcholinesterase
650 $aAntioxidants
650 $aEssential oils
650 $aSpectroscopy
650 $aAntioxidante
650 $aÓleo Essencial
653 $aAcetilcolinesterase
653 $aEspectroscopia
653 $aLibidibia ferrea
700 1 $aBARBOSA, S. I. C. G.
700 1 $aFEITOSA, C. C.
700 1 $aLOPES, F. F. DA S.
700 1 $aOLIVEIRA, D. P. DE
700 1 $aFREITAS, L. S.
700 1 $aMATTOS, A. L. A.
700 1 $aSILVA, W. M. B. DA
700 1 $aISHIKI, H. M.
700 1 $aMORAES, S. M. DE
773 $tChemistry & Biodiversity, 0:e00550, 2025.
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Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
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