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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
26/07/2018 |
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Data da última atualização: |
26/07/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
NUNES, K. S. D.; VALLIM, J. H.; ASSALIN, M. R.; QUEIROZ, S. C. do N. de; PARAIBA, L. C.; JONSSON, C. M.; REYES, F. G. R. |
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Afiliação: |
KATIA SANTOS DAMACENA NUNES, FEA-Unicamp; JOSE HENRIQUE VALLIM, CNPMA; MARCIA REGINA ASSALIN, CNPMA; SONIA CLAUDIA DO N DE QUEIROZ, CNPMA; LOURIVAL COSTA PARAIBA, CNPMA; CLAUDIO MARTIN JONSSON, CNPMA; FELIX GUILLERMO REYSE REYES, FEA-Unicamp. |
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Título: |
Depletion study, withdrawal period calculation and bioaccumulation of sulfamethazine in tilapia (Oreochromis niloticus) treated with medicated feed. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Chemosphere, v. 197, p. 89-85, 2018. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The residue depletion of sulfamethazine (SMZ) was evaluated in tilapia (Oreochromis niloticus) after 11 days of administration of medicated feed containing SMZ, at the dose of 422/mg/kg body weight (bw). The determination of SMZ in feed and tilapia fillet was carried out using the QuEChERS approach for sample preparation, and high performance liquid chromatography with diode array detector (HPLC-DAD) and ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QToF-MS) for quantitation, respectively. Both methods were validated based on international and Brazilian guidelines and shown to be suitable for the intended purposes. The withdrawal period to reach the maximum residue level (MRL) of 100microgr5am/kg, according to the European Union (EU) legislative framework to all substances belonging to the sulfonamide (SA) group (EU, 2010), was 10 days (260°C-day). After treatment, the maximum level of SMZ accumulation in the tilapia muscle was 1.6?mg/kg. SMZ was shown to be quickly excreted by tilapia. Thus, considering the acceptable daily intake of SMZ established by the Codex Commission (0?0.05 mg/kg bw), and a factor of 5 times the upper amount of fish consumption in Brazil (38/kg/year), this study showed that there is a low risk of adverse effects to consumers. This study offers subsidies not only for the establishment of public policies with regard to the use of veterinary drugs currently not allowed in a country by their legal legislative framework for fish farming, but also to fish producers for the proper handling to ensure safe fish fillets. MenosAbstract: The residue depletion of sulfamethazine (SMZ) was evaluated in tilapia (Oreochromis niloticus) after 11 days of administration of medicated feed containing SMZ, at the dose of 422/mg/kg body weight (bw). The determination of SMZ in feed and tilapia fillet was carried out using the QuEChERS approach for sample preparation, and high performance liquid chromatography with diode array detector (HPLC-DAD) and ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QToF-MS) for quantitation, respectively. Both methods were validated based on international and Brazilian guidelines and shown to be suitable for the intended purposes. The withdrawal period to reach the maximum residue level (MRL) of 100microgr5am/kg, according to the European Union (EU) legislative framework to all substances belonging to the sulfonamide (SA) group (EU, 2010), was 10 days (260°C-day). After treatment, the maximum level of SMZ accumulation in the tilapia muscle was 1.6?mg/kg. SMZ was shown to be quickly excreted by tilapia. Thus, considering the acceptable daily intake of SMZ established by the Codex Commission (0?0.05 mg/kg bw), and a factor of 5 times the upper amount of fish consumption in Brazil (38/kg/year), this study showed that there is a low risk of adverse effects to consumers. This study offers subsidies not only for the establishment of public policies with regard to the use of veterinary drugs currently not allowed in a country by their lega... Mostrar Tudo |
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Palavras-Chave: |
Depletion study; LC-MS/MS; QuEChERS; Sulfadimidine; Sulfamethazine. |
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Thesagro: |
Análise Química; Cromatografia; Espectrometria; Medicamento; Resíduo Quimico; Tilápia; Tilápia nilótica. |
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Thesaurus Nal: |
Analytical chemistry; Analytical methods; Drug residues; Freshwater fish; High performance liquid chromatography; Ultra-performance liquid chromatography. |
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Categoria do assunto: |
W Química e Física |
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Marc: |
LEADER 02853naa a2200409 a 4500
001 2093569
005 2018-07-26
008 2018 bl uuuu u00u1 u #d
100 1 $aNUNES, K. S. D.
245 $aDepletion study, withdrawal period calculation and bioaccumulation of sulfamethazine in tilapia (Oreochromis niloticus) treated with medicated feed.$h[electronic resource]
260 $c2018
520 $aAbstract: The residue depletion of sulfamethazine (SMZ) was evaluated in tilapia (Oreochromis niloticus) after 11 days of administration of medicated feed containing SMZ, at the dose of 422/mg/kg body weight (bw). The determination of SMZ in feed and tilapia fillet was carried out using the QuEChERS approach for sample preparation, and high performance liquid chromatography with diode array detector (HPLC-DAD) and ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QToF-MS) for quantitation, respectively. Both methods were validated based on international and Brazilian guidelines and shown to be suitable for the intended purposes. The withdrawal period to reach the maximum residue level (MRL) of 100microgr5am/kg, according to the European Union (EU) legislative framework to all substances belonging to the sulfonamide (SA) group (EU, 2010), was 10 days (260°C-day). After treatment, the maximum level of SMZ accumulation in the tilapia muscle was 1.6?mg/kg. SMZ was shown to be quickly excreted by tilapia. Thus, considering the acceptable daily intake of SMZ established by the Codex Commission (0?0.05 mg/kg bw), and a factor of 5 times the upper amount of fish consumption in Brazil (38/kg/year), this study showed that there is a low risk of adverse effects to consumers. This study offers subsidies not only for the establishment of public policies with regard to the use of veterinary drugs currently not allowed in a country by their legal legislative framework for fish farming, but also to fish producers for the proper handling to ensure safe fish fillets.
650 $aAnalytical chemistry
650 $aAnalytical methods
650 $aDrug residues
650 $aFreshwater fish
650 $aHigh performance liquid chromatography
650 $aUltra-performance liquid chromatography
650 $aAnálise Química
650 $aCromatografia
650 $aEspectrometria
650 $aMedicamento
650 $aResíduo Quimico
650 $aTilápia
650 $aTilápia nilótica
653 $aDepletion study
653 $aLC-MS/MS
653 $aQuEChERS
653 $aSulfadimidine
653 $aSulfamethazine
700 1 $aVALLIM, J. H.
700 1 $aASSALIN, M. R.
700 1 $aQUEIROZ, S. C. do N. de
700 1 $aPARAIBA, L. C.
700 1 $aJONSSON, C. M.
700 1 $aREYES, F. G. R.
773 $tChemosphere$gv. 197, p. 89-85, 2018.
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Registro original: |
Embrapa Meio Ambiente (CNPMA) |
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| Registros recuperados : 10 | |
| 2. |  | VITCOSQUE, G. L.; FARINAS, C. S.; FONSECA, R. F.; BERTUCCI NETO, V. Improving cellulolytic enzyme production using sugarcane bagasse in a solid-state fermentation bioreactor. Holos environment, Rio Claro, v. 11, n. 1, p. 103, 2011. Supl. 1. Edição dos resumos do 5 Simpósio de Microbiologia Aplicada, Rio Claro, maio 2011.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 4 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 6. | | FARINAS, C. S.; VITCOSQUE, G. L.; FONSECA, R. F.; BERTUCCI NETO, V.; COURI, S. Modeling the effects of solid state fermentation operating conditions on endoglucanase production using an instrumented bioreactor. Industrial crops and products, [S. l.], v. 34, n. 1, p. 1186-1192, 2011.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroindústria de Alimentos; Embrapa Instrumentação. |
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| 9. | | VITCOSQUE, G. L.; FONSECA, R. F.; RODRÍGUEZ-ZUÑIGA, U. F.; BERTUCCI-NETO, V.; COURI, S.; FARINAS, C. S. Use of instrumented bioreactor for the production of biomass-degrading multienzymes under solid state fermentation of soybean meal. In: SYMPOSIUM ON BIOTECHNOLOGY FOR FUELS AND CHEMICALS, 34., 2012, New Orleans. Abstract... Old Lee Highway: Society for Industrial Microbiology & Biotechnology, 2012. Paper 20758.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 10. | | VITCOSQUE, G. L.; RIBEIRO, L. F. C.; LUCAS, R. C. de; SILVA, T. M. da; RIBEIRO, L. F.; DAMASIO, A. R. de L.; FARINAS, C. S.; GONCALVES, A. Z. L.; SEGATO, F.; BUCKERIDGE, M. S.; JORGE, J. A.; POLIZELI, M. de L. T. M. The functional properties of a xyloglucanase (GH12) of Aspergillus terreus expressed in Aspergillus nidulans may increase performance of biomass degradation. Applied microbiology and biotechnology, [S. ], v. 100, n. 21, p. 9133-9144, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Instrumentação. |
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| Registros recuperados : 10 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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